TY - JOUR
T1 - Association of aldehyde dehydrogenase 2 genotype with prevalence of diabetic retinopathy
AU - Suzuki, Yoshihiko
AU - Murata, Chisato
AU - Atsumi, Yoshito
AU - Matsuoka, Kempei
AU - Asahina, Takayuki
AU - Shimada, Akira
AU - Hosokawa, Kazuhiro
AU - Taniyama, Matsuo
AU - Muramatsu, Taro
PY - 1997/8/1
Y1 - 1997/8/1
N2 - The influence of aldehyde dehydrogenase 2 (ALDH 2) genotype on diabetic retinopathy was investigated in 212 individuals with non-insulin dependent diabetes mellitus (NIDDM). The prevalence of proliferative retinopathy was lower [p < 0.05) in the 92 patients with inactive ALDH 2 than in the 120 patients with active ALDH2. In patients with NIDDM of less than 10 years' duration, the prevalence of proliferative retinopathy was 6.5% (4/62) in those with active ALDH 2 and 0% (0/45) in those with inactive ALDH 2. In patients with NIDDM of more than 10 years' duration, the prevalence of proliferative retinopathy was 12.1% (7/58) among those with active ALDH 2 and 4.3% (2/47) among those with inactive ALDH 2. Thus, the prevalence of proliferative retinopathy was relatively high and its onset earlier in patients with active ALDH 2 genotype compared to those with inactive ALDH 2 genotype. From these results, we suggest that ALDH 2 genotype could be a genetic marker for diabetic retinopathy, especially among those with NIDDM.
AB - The influence of aldehyde dehydrogenase 2 (ALDH 2) genotype on diabetic retinopathy was investigated in 212 individuals with non-insulin dependent diabetes mellitus (NIDDM). The prevalence of proliferative retinopathy was lower [p < 0.05) in the 92 patients with inactive ALDH 2 than in the 120 patients with active ALDH2. In patients with NIDDM of less than 10 years' duration, the prevalence of proliferative retinopathy was 6.5% (4/62) in those with active ALDH 2 and 0% (0/45) in those with inactive ALDH 2. In patients with NIDDM of more than 10 years' duration, the prevalence of proliferative retinopathy was 12.1% (7/58) among those with active ALDH 2 and 4.3% (2/47) among those with inactive ALDH 2. Thus, the prevalence of proliferative retinopathy was relatively high and its onset earlier in patients with active ALDH 2 genotype compared to those with inactive ALDH 2 genotype. From these results, we suggest that ALDH 2 genotype could be a genetic marker for diabetic retinopathy, especially among those with NIDDM.
KW - ALDH 2
KW - Aldehyde Dehydrogenase
KW - Chlorpropamide Alcohol Flushing Test
KW - Diabetes Mellitus
KW - Diabetic Retinopathy
UR - http://www.scopus.com/inward/record.url?scp=0030667563&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030667563&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0030667563
SN - 0015-5667
VL - 48
SP - 955
EP - 958
JO - Folia Ophthalmologica Japonica
JF - Folia Ophthalmologica Japonica
IS - 8
ER -
