Association of aldehyde dehydrogenase with inheritance of NIDDM

Y. Suzuki, Taro Muramatsu, M. Taniyama, Y. Atsumi, R. Kawaguchi, S. Higuchi, K. Hosokawa, T. Asahina, C. Murata, K. Matsuoka

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

To investigate the influence of the mitochondrial aldehyde dehydrogenase 2 (ALDH2) genotype on the clinical features of diabetes, 212 Japanese patients with non-insulin-dependent diabetes mellitus (NIDDM) (154 males and 58 females aged 17-83 years; mean age 58.2 years) were investigated. Genotyping of ALDH2 was performed by the polymerase chain reaction - restriction fragment length polymorphism (PCR-RFLP) method. The pattern of inheritance of diabetes and various clinical parameters was compared between active and inactive ALDH2 groups. Of the 212 subjects, 120 had active ALDH2 and 92 had inactive ALDH2. The percentage of patients with a diabetic mother was higher in the inactive ALDH2 group (32.6 %) than in the active ALDH2 group (19.2 %) (p < 0.05). The prevalence of proliferative retinopathy was lower in the inactive ALDH2 group than in the active ALDH2 group (p < 0.05). However, other clinical parameters showed no difference. We conclude that maternal inheritance of diabetes was common in the inactive ALDH2 group. The finding is suggestive of a relationship between alcohol intolerance and inheritance of diabetes. We speculate that the interaction between mitochondrial DNA and ALDH2 inactivity causes an increase of mitochondrial DNA mutations or deletions, thereby inducing the maternal inheritance of diabetes. The relationship of the ALDH2 genotype with proliferative retinopathy is interesting, because it resembles that of chlorpropamide alcohol flushing with severe diabetic retinopathy. The interaction of aldehyde dehydrogenase isoenzymes might have an aetiological role, since aldehyde dehydrogenase 1 plays an important part in oxidation of retinal to retinoic acid. However, the number of affected patients with proliferative retinopathy was small, hence, our result should be considered as a preliminary finding.

Original languageEnglish
Pages (from-to)1115-1118
Number of pages4
JournalDiabetologia
Volume39
Issue number9
DOIs
Publication statusPublished - 1996
Externally publishedYes

Fingerprint

Aldehyde Dehydrogenase
Type 2 Diabetes Mellitus
Mitochondrial DNA
Genotype
Inheritance Patterns
Sequence Deletion
Diabetic Retinopathy
Tretinoin
Restriction Fragment Length Polymorphisms
Isoenzymes
Alcohols
Mothers

Keywords

  • Aldehyde dehydrogenase
  • ALDH2
  • Chlorpromide alcohol flushing test
  • Diabetes mellitus
  • Diabetic retinopathy

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Suzuki, Y., Muramatsu, T., Taniyama, M., Atsumi, Y., Kawaguchi, R., Higuchi, S., ... Matsuoka, K. (1996). Association of aldehyde dehydrogenase with inheritance of NIDDM. Diabetologia, 39(9), 1115-1118. https://doi.org/10.1007/s001250050561

Association of aldehyde dehydrogenase with inheritance of NIDDM. / Suzuki, Y.; Muramatsu, Taro; Taniyama, M.; Atsumi, Y.; Kawaguchi, R.; Higuchi, S.; Hosokawa, K.; Asahina, T.; Murata, C.; Matsuoka, K.

In: Diabetologia, Vol. 39, No. 9, 1996, p. 1115-1118.

Research output: Contribution to journalArticle

Suzuki, Y, Muramatsu, T, Taniyama, M, Atsumi, Y, Kawaguchi, R, Higuchi, S, Hosokawa, K, Asahina, T, Murata, C & Matsuoka, K 1996, 'Association of aldehyde dehydrogenase with inheritance of NIDDM', Diabetologia, vol. 39, no. 9, pp. 1115-1118. https://doi.org/10.1007/s001250050561
Suzuki Y, Muramatsu T, Taniyama M, Atsumi Y, Kawaguchi R, Higuchi S et al. Association of aldehyde dehydrogenase with inheritance of NIDDM. Diabetologia. 1996;39(9):1115-1118. https://doi.org/10.1007/s001250050561
Suzuki, Y. ; Muramatsu, Taro ; Taniyama, M. ; Atsumi, Y. ; Kawaguchi, R. ; Higuchi, S. ; Hosokawa, K. ; Asahina, T. ; Murata, C. ; Matsuoka, K. / Association of aldehyde dehydrogenase with inheritance of NIDDM. In: Diabetologia. 1996 ; Vol. 39, No. 9. pp. 1115-1118.
@article{9397e158faf345bcb073eaa0e72c9557,
title = "Association of aldehyde dehydrogenase with inheritance of NIDDM",
abstract = "To investigate the influence of the mitochondrial aldehyde dehydrogenase 2 (ALDH2) genotype on the clinical features of diabetes, 212 Japanese patients with non-insulin-dependent diabetes mellitus (NIDDM) (154 males and 58 females aged 17-83 years; mean age 58.2 years) were investigated. Genotyping of ALDH2 was performed by the polymerase chain reaction - restriction fragment length polymorphism (PCR-RFLP) method. The pattern of inheritance of diabetes and various clinical parameters was compared between active and inactive ALDH2 groups. Of the 212 subjects, 120 had active ALDH2 and 92 had inactive ALDH2. The percentage of patients with a diabetic mother was higher in the inactive ALDH2 group (32.6 {\%}) than in the active ALDH2 group (19.2 {\%}) (p < 0.05). The prevalence of proliferative retinopathy was lower in the inactive ALDH2 group than in the active ALDH2 group (p < 0.05). However, other clinical parameters showed no difference. We conclude that maternal inheritance of diabetes was common in the inactive ALDH2 group. The finding is suggestive of a relationship between alcohol intolerance and inheritance of diabetes. We speculate that the interaction between mitochondrial DNA and ALDH2 inactivity causes an increase of mitochondrial DNA mutations or deletions, thereby inducing the maternal inheritance of diabetes. The relationship of the ALDH2 genotype with proliferative retinopathy is interesting, because it resembles that of chlorpropamide alcohol flushing with severe diabetic retinopathy. The interaction of aldehyde dehydrogenase isoenzymes might have an aetiological role, since aldehyde dehydrogenase 1 plays an important part in oxidation of retinal to retinoic acid. However, the number of affected patients with proliferative retinopathy was small, hence, our result should be considered as a preliminary finding.",
keywords = "Aldehyde dehydrogenase, ALDH2, Chlorpromide alcohol flushing test, Diabetes mellitus, Diabetic retinopathy",
author = "Y. Suzuki and Taro Muramatsu and M. Taniyama and Y. Atsumi and R. Kawaguchi and S. Higuchi and K. Hosokawa and T. Asahina and C. Murata and K. Matsuoka",
year = "1996",
doi = "10.1007/s001250050561",
language = "English",
volume = "39",
pages = "1115--1118",
journal = "Diabetologia",
issn = "0012-186X",
publisher = "Springer Verlag",
number = "9",

}

TY - JOUR

T1 - Association of aldehyde dehydrogenase with inheritance of NIDDM

AU - Suzuki, Y.

AU - Muramatsu, Taro

AU - Taniyama, M.

AU - Atsumi, Y.

AU - Kawaguchi, R.

AU - Higuchi, S.

AU - Hosokawa, K.

AU - Asahina, T.

AU - Murata, C.

AU - Matsuoka, K.

PY - 1996

Y1 - 1996

N2 - To investigate the influence of the mitochondrial aldehyde dehydrogenase 2 (ALDH2) genotype on the clinical features of diabetes, 212 Japanese patients with non-insulin-dependent diabetes mellitus (NIDDM) (154 males and 58 females aged 17-83 years; mean age 58.2 years) were investigated. Genotyping of ALDH2 was performed by the polymerase chain reaction - restriction fragment length polymorphism (PCR-RFLP) method. The pattern of inheritance of diabetes and various clinical parameters was compared between active and inactive ALDH2 groups. Of the 212 subjects, 120 had active ALDH2 and 92 had inactive ALDH2. The percentage of patients with a diabetic mother was higher in the inactive ALDH2 group (32.6 %) than in the active ALDH2 group (19.2 %) (p < 0.05). The prevalence of proliferative retinopathy was lower in the inactive ALDH2 group than in the active ALDH2 group (p < 0.05). However, other clinical parameters showed no difference. We conclude that maternal inheritance of diabetes was common in the inactive ALDH2 group. The finding is suggestive of a relationship between alcohol intolerance and inheritance of diabetes. We speculate that the interaction between mitochondrial DNA and ALDH2 inactivity causes an increase of mitochondrial DNA mutations or deletions, thereby inducing the maternal inheritance of diabetes. The relationship of the ALDH2 genotype with proliferative retinopathy is interesting, because it resembles that of chlorpropamide alcohol flushing with severe diabetic retinopathy. The interaction of aldehyde dehydrogenase isoenzymes might have an aetiological role, since aldehyde dehydrogenase 1 plays an important part in oxidation of retinal to retinoic acid. However, the number of affected patients with proliferative retinopathy was small, hence, our result should be considered as a preliminary finding.

AB - To investigate the influence of the mitochondrial aldehyde dehydrogenase 2 (ALDH2) genotype on the clinical features of diabetes, 212 Japanese patients with non-insulin-dependent diabetes mellitus (NIDDM) (154 males and 58 females aged 17-83 years; mean age 58.2 years) were investigated. Genotyping of ALDH2 was performed by the polymerase chain reaction - restriction fragment length polymorphism (PCR-RFLP) method. The pattern of inheritance of diabetes and various clinical parameters was compared between active and inactive ALDH2 groups. Of the 212 subjects, 120 had active ALDH2 and 92 had inactive ALDH2. The percentage of patients with a diabetic mother was higher in the inactive ALDH2 group (32.6 %) than in the active ALDH2 group (19.2 %) (p < 0.05). The prevalence of proliferative retinopathy was lower in the inactive ALDH2 group than in the active ALDH2 group (p < 0.05). However, other clinical parameters showed no difference. We conclude that maternal inheritance of diabetes was common in the inactive ALDH2 group. The finding is suggestive of a relationship between alcohol intolerance and inheritance of diabetes. We speculate that the interaction between mitochondrial DNA and ALDH2 inactivity causes an increase of mitochondrial DNA mutations or deletions, thereby inducing the maternal inheritance of diabetes. The relationship of the ALDH2 genotype with proliferative retinopathy is interesting, because it resembles that of chlorpropamide alcohol flushing with severe diabetic retinopathy. The interaction of aldehyde dehydrogenase isoenzymes might have an aetiological role, since aldehyde dehydrogenase 1 plays an important part in oxidation of retinal to retinoic acid. However, the number of affected patients with proliferative retinopathy was small, hence, our result should be considered as a preliminary finding.

KW - Aldehyde dehydrogenase

KW - ALDH2

KW - Chlorpromide alcohol flushing test

KW - Diabetes mellitus

KW - Diabetic retinopathy

UR - http://www.scopus.com/inward/record.url?scp=9444277158&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=9444277158&partnerID=8YFLogxK

U2 - 10.1007/s001250050561

DO - 10.1007/s001250050561

M3 - Article

VL - 39

SP - 1115

EP - 1118

JO - Diabetologia

JF - Diabetologia

SN - 0012-186X

IS - 9

ER -