Association of arterial stiffness with silent cerebrovascular lesions

The Ohasama study

Rieko Hatanaka, Taku Obara, Daisuke Watabe, Tomofumi Ishikawa, Takeo Kondo, Kazuki Ishikura, Tomoyuki Aikawa, Yoko Aono, Azusa Hara, Hirohito Metoki, Kei Asayama, Masahiro Kikuya, Nariyasu Mano, Takayoshi Ohkubo, Shin Ichi Izumi, Yutaka Imai

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Background: Arterial stiffness is a risk factor for symptomatic stroke, and is associated with symptomatic cerebral infarction and cognitive impairment. Hence, we hypothesized that arterial stiffness would be a significant determinant of silent cerebrovascular lesions. Methods: The subjects were 363 individuals without symptomatic cerebrovascular lesions who had their arterial stiffness assessed by brachial-ankle pulse wave velocity (baPWV) measurement. The subjects were classified into two groups by the presence or absence of lacunar infarcts, as well as into three groups by grade of white matter hyperintensity (WMH). baPWV was compared among these groups. Results: Eighty-six subjects had lacunar infarcts. Of 138 subjects with WMHs, 102 were classified as having grade 1 and 36 as having grade 2 or 3 WMHs. baPWV was significantly higher in subjects with lacunar infarcts than in those without (17.3 ± 0.3 vs. 16.4 ± 0.2 m/s). baPWV tended to increase with higher WMH grade (16.2 ± 0.2, 16.9 ± 0.3, and 17.8 ± 0.5 m/s in grade 0, 1, and 2 or 3, respectively) after adjustments for confounding factors. The adjusted odds ratio (OR) for lacunar infarcts in subjects with middle-tertile baPWV was significantly higher (OR, 2.37; 95% confidence interval, CI, 1.10-5.11) and the OR in subjects with the highest-tertile baPWV tended to be higher (OR 2.26; 95% CI 0.99-5.45) compared with the lowest-tertile baPWV. The adjusted OR for WMH tended to increase with increased baPWV. Conclusions: Arterial stiffness appeared to be associated with the presence of a lacunar infarct and WMH, independently of the risks for other cerebrovascular diseases.

Original languageEnglish
Pages (from-to)329-337
Number of pages9
JournalCerebrovascular Diseases
Volume31
Issue number4
DOIs
Publication statusPublished - 2011 Mar 1
Externally publishedYes

Fingerprint

Pulse Wave Analysis
Vascular Stiffness
Ankle
Lacunar Stroke
Arm
Odds Ratio
Cerebrovascular Disorders
Cerebral Infarction
Stroke
Confidence Intervals
White Matter

Keywords

  • Ambulatory blood pressure
  • Arterial stiffness
  • Lacunar infarct
  • Silent cerebrovascular lesions
  • White matter hyperintensity

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

Hatanaka, R., Obara, T., Watabe, D., Ishikawa, T., Kondo, T., Ishikura, K., ... Imai, Y. (2011). Association of arterial stiffness with silent cerebrovascular lesions: The Ohasama study. Cerebrovascular Diseases, 31(4), 329-337. https://doi.org/10.1159/000322599

Association of arterial stiffness with silent cerebrovascular lesions : The Ohasama study. / Hatanaka, Rieko; Obara, Taku; Watabe, Daisuke; Ishikawa, Tomofumi; Kondo, Takeo; Ishikura, Kazuki; Aikawa, Tomoyuki; Aono, Yoko; Hara, Azusa; Metoki, Hirohito; Asayama, Kei; Kikuya, Masahiro; Mano, Nariyasu; Ohkubo, Takayoshi; Izumi, Shin Ichi; Imai, Yutaka.

In: Cerebrovascular Diseases, Vol. 31, No. 4, 01.03.2011, p. 329-337.

Research output: Contribution to journalArticle

Hatanaka, R, Obara, T, Watabe, D, Ishikawa, T, Kondo, T, Ishikura, K, Aikawa, T, Aono, Y, Hara, A, Metoki, H, Asayama, K, Kikuya, M, Mano, N, Ohkubo, T, Izumi, SI & Imai, Y 2011, 'Association of arterial stiffness with silent cerebrovascular lesions: The Ohasama study', Cerebrovascular Diseases, vol. 31, no. 4, pp. 329-337. https://doi.org/10.1159/000322599
Hatanaka R, Obara T, Watabe D, Ishikawa T, Kondo T, Ishikura K et al. Association of arterial stiffness with silent cerebrovascular lesions: The Ohasama study. Cerebrovascular Diseases. 2011 Mar 1;31(4):329-337. https://doi.org/10.1159/000322599
Hatanaka, Rieko ; Obara, Taku ; Watabe, Daisuke ; Ishikawa, Tomofumi ; Kondo, Takeo ; Ishikura, Kazuki ; Aikawa, Tomoyuki ; Aono, Yoko ; Hara, Azusa ; Metoki, Hirohito ; Asayama, Kei ; Kikuya, Masahiro ; Mano, Nariyasu ; Ohkubo, Takayoshi ; Izumi, Shin Ichi ; Imai, Yutaka. / Association of arterial stiffness with silent cerebrovascular lesions : The Ohasama study. In: Cerebrovascular Diseases. 2011 ; Vol. 31, No. 4. pp. 329-337.
@article{fdd2ecd811f04966add4a3c1c114f2a0,
title = "Association of arterial stiffness with silent cerebrovascular lesions: The Ohasama study",
abstract = "Background: Arterial stiffness is a risk factor for symptomatic stroke, and is associated with symptomatic cerebral infarction and cognitive impairment. Hence, we hypothesized that arterial stiffness would be a significant determinant of silent cerebrovascular lesions. Methods: The subjects were 363 individuals without symptomatic cerebrovascular lesions who had their arterial stiffness assessed by brachial-ankle pulse wave velocity (baPWV) measurement. The subjects were classified into two groups by the presence or absence of lacunar infarcts, as well as into three groups by grade of white matter hyperintensity (WMH). baPWV was compared among these groups. Results: Eighty-six subjects had lacunar infarcts. Of 138 subjects with WMHs, 102 were classified as having grade 1 and 36 as having grade 2 or 3 WMHs. baPWV was significantly higher in subjects with lacunar infarcts than in those without (17.3 ± 0.3 vs. 16.4 ± 0.2 m/s). baPWV tended to increase with higher WMH grade (16.2 ± 0.2, 16.9 ± 0.3, and 17.8 ± 0.5 m/s in grade 0, 1, and 2 or 3, respectively) after adjustments for confounding factors. The adjusted odds ratio (OR) for lacunar infarcts in subjects with middle-tertile baPWV was significantly higher (OR, 2.37; 95{\%} confidence interval, CI, 1.10-5.11) and the OR in subjects with the highest-tertile baPWV tended to be higher (OR 2.26; 95{\%} CI 0.99-5.45) compared with the lowest-tertile baPWV. The adjusted OR for WMH tended to increase with increased baPWV. Conclusions: Arterial stiffness appeared to be associated with the presence of a lacunar infarct and WMH, independently of the risks for other cerebrovascular diseases.",
keywords = "Ambulatory blood pressure, Arterial stiffness, Lacunar infarct, Silent cerebrovascular lesions, White matter hyperintensity",
author = "Rieko Hatanaka and Taku Obara and Daisuke Watabe and Tomofumi Ishikawa and Takeo Kondo and Kazuki Ishikura and Tomoyuki Aikawa and Yoko Aono and Azusa Hara and Hirohito Metoki and Kei Asayama and Masahiro Kikuya and Nariyasu Mano and Takayoshi Ohkubo and Izumi, {Shin Ichi} and Yutaka Imai",
year = "2011",
month = "3",
day = "1",
doi = "10.1159/000322599",
language = "English",
volume = "31",
pages = "329--337",
journal = "Cerebrovascular Diseases",
issn = "1015-9770",
publisher = "S. Karger AG",
number = "4",

}

TY - JOUR

T1 - Association of arterial stiffness with silent cerebrovascular lesions

T2 - The Ohasama study

AU - Hatanaka, Rieko

AU - Obara, Taku

AU - Watabe, Daisuke

AU - Ishikawa, Tomofumi

AU - Kondo, Takeo

AU - Ishikura, Kazuki

AU - Aikawa, Tomoyuki

AU - Aono, Yoko

AU - Hara, Azusa

AU - Metoki, Hirohito

AU - Asayama, Kei

AU - Kikuya, Masahiro

AU - Mano, Nariyasu

AU - Ohkubo, Takayoshi

AU - Izumi, Shin Ichi

AU - Imai, Yutaka

PY - 2011/3/1

Y1 - 2011/3/1

N2 - Background: Arterial stiffness is a risk factor for symptomatic stroke, and is associated with symptomatic cerebral infarction and cognitive impairment. Hence, we hypothesized that arterial stiffness would be a significant determinant of silent cerebrovascular lesions. Methods: The subjects were 363 individuals without symptomatic cerebrovascular lesions who had their arterial stiffness assessed by brachial-ankle pulse wave velocity (baPWV) measurement. The subjects were classified into two groups by the presence or absence of lacunar infarcts, as well as into three groups by grade of white matter hyperintensity (WMH). baPWV was compared among these groups. Results: Eighty-six subjects had lacunar infarcts. Of 138 subjects with WMHs, 102 were classified as having grade 1 and 36 as having grade 2 or 3 WMHs. baPWV was significantly higher in subjects with lacunar infarcts than in those without (17.3 ± 0.3 vs. 16.4 ± 0.2 m/s). baPWV tended to increase with higher WMH grade (16.2 ± 0.2, 16.9 ± 0.3, and 17.8 ± 0.5 m/s in grade 0, 1, and 2 or 3, respectively) after adjustments for confounding factors. The adjusted odds ratio (OR) for lacunar infarcts in subjects with middle-tertile baPWV was significantly higher (OR, 2.37; 95% confidence interval, CI, 1.10-5.11) and the OR in subjects with the highest-tertile baPWV tended to be higher (OR 2.26; 95% CI 0.99-5.45) compared with the lowest-tertile baPWV. The adjusted OR for WMH tended to increase with increased baPWV. Conclusions: Arterial stiffness appeared to be associated with the presence of a lacunar infarct and WMH, independently of the risks for other cerebrovascular diseases.

AB - Background: Arterial stiffness is a risk factor for symptomatic stroke, and is associated with symptomatic cerebral infarction and cognitive impairment. Hence, we hypothesized that arterial stiffness would be a significant determinant of silent cerebrovascular lesions. Methods: The subjects were 363 individuals without symptomatic cerebrovascular lesions who had their arterial stiffness assessed by brachial-ankle pulse wave velocity (baPWV) measurement. The subjects were classified into two groups by the presence or absence of lacunar infarcts, as well as into three groups by grade of white matter hyperintensity (WMH). baPWV was compared among these groups. Results: Eighty-six subjects had lacunar infarcts. Of 138 subjects with WMHs, 102 were classified as having grade 1 and 36 as having grade 2 or 3 WMHs. baPWV was significantly higher in subjects with lacunar infarcts than in those without (17.3 ± 0.3 vs. 16.4 ± 0.2 m/s). baPWV tended to increase with higher WMH grade (16.2 ± 0.2, 16.9 ± 0.3, and 17.8 ± 0.5 m/s in grade 0, 1, and 2 or 3, respectively) after adjustments for confounding factors. The adjusted odds ratio (OR) for lacunar infarcts in subjects with middle-tertile baPWV was significantly higher (OR, 2.37; 95% confidence interval, CI, 1.10-5.11) and the OR in subjects with the highest-tertile baPWV tended to be higher (OR 2.26; 95% CI 0.99-5.45) compared with the lowest-tertile baPWV. The adjusted OR for WMH tended to increase with increased baPWV. Conclusions: Arterial stiffness appeared to be associated with the presence of a lacunar infarct and WMH, independently of the risks for other cerebrovascular diseases.

KW - Ambulatory blood pressure

KW - Arterial stiffness

KW - Lacunar infarct

KW - Silent cerebrovascular lesions

KW - White matter hyperintensity

UR - http://www.scopus.com/inward/record.url?scp=78650878677&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78650878677&partnerID=8YFLogxK

U2 - 10.1159/000322599

DO - 10.1159/000322599

M3 - Article

VL - 31

SP - 329

EP - 337

JO - Cerebrovascular Diseases

JF - Cerebrovascular Diseases

SN - 1015-9770

IS - 4

ER -