Association of calcineurin A gamma subunit (PPP3CC) and early growth response 3 (EGR3) gene polymorphisms with susceptibility to schizophrenia in a Japanese population

Chieko Kyogoku, Masaya Yanagi, Kunihiro Nishimura, Daisuke Sugiyama, Akio Morinobu, Masaaki Fukutake, Kiyoshi Maeda, Osamu Shirakawa, Takayoshi Kuno, Shunichi Kumagai

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15 Citations (Scopus)


To examine the association of PPP3CC (rs10108011 and rs2461491) and EGR3 (rs3750192) single-nucleotide polymorphisms (SNPs) with Japanese schizophrenia, we performed a case-control association study using 337 patients and 369 healthy controls. As a result, by our moderated cohort-size study, PPP3CC and EGR3 are not genetic risk factors for schizophrenia, whereas meta-analysis showed weak association of rs10108011 with schizophrenia in the Japanese population (odds ratio (OR) = 1.12, P= 0.01).

Original languageEnglish
Pages (from-to)16-19
Number of pages4
JournalPsychiatry Research
Issue number1-2
Publication statusPublished - 2011 Jan 30
Externally publishedYes



  • Calcineurin A gamma subunit (PPP3CC)
  • Early growth response 3 (EGR3)
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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