Association of calcineurin A gamma subunit (PPP3CC) and early growth response 3 (EGR3) gene polymorphisms with susceptibility to schizophrenia in a Japanese population

Chieko Kyogoku, Masaya Yanagi, Kunihiro Nishimura, Daisuke Sugiyama, Akio Morinobu, Masaaki Fukutake, Kiyoshi Maeda, Osamu Shirakawa, Takayoshi Kuno, Shunichi Kumagai

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

To examine the association of PPP3CC (rs10108011 and rs2461491) and EGR3 (rs3750192) single-nucleotide polymorphisms (SNPs) with Japanese schizophrenia, we performed a case-control association study using 337 patients and 369 healthy controls. As a result, by our moderated cohort-size study, PPP3CC and EGR3 are not genetic risk factors for schizophrenia, whereas meta-analysis showed weak association of rs10108011 with schizophrenia in the Japanese population (odds ratio (OR) = 1.12, P= 0.01).

Original languageEnglish
Pages (from-to)16-19
Number of pages4
JournalPsychiatry Research
Volume185
Issue number1-2
DOIs
Publication statusPublished - 2011 Jan 30
Externally publishedYes

Fingerprint

Calcineurin
Schizophrenia
Growth
Population
Genes
Single Nucleotide Polymorphism
Meta-Analysis
Case-Control Studies
Cohort Studies
Odds Ratio

Keywords

  • Calcineurin A gamma subunit (PPP3CC)
  • Early growth response 3 (EGR3)
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Association of calcineurin A gamma subunit (PPP3CC) and early growth response 3 (EGR3) gene polymorphisms with susceptibility to schizophrenia in a Japanese population. / Kyogoku, Chieko; Yanagi, Masaya; Nishimura, Kunihiro; Sugiyama, Daisuke; Morinobu, Akio; Fukutake, Masaaki; Maeda, Kiyoshi; Shirakawa, Osamu; Kuno, Takayoshi; Kumagai, Shunichi.

In: Psychiatry Research, Vol. 185, No. 1-2, 30.01.2011, p. 16-19.

Research output: Contribution to journalArticle

Kyogoku, Chieko ; Yanagi, Masaya ; Nishimura, Kunihiro ; Sugiyama, Daisuke ; Morinobu, Akio ; Fukutake, Masaaki ; Maeda, Kiyoshi ; Shirakawa, Osamu ; Kuno, Takayoshi ; Kumagai, Shunichi. / Association of calcineurin A gamma subunit (PPP3CC) and early growth response 3 (EGR3) gene polymorphisms with susceptibility to schizophrenia in a Japanese population. In: Psychiatry Research. 2011 ; Vol. 185, No. 1-2. pp. 16-19.
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AU - Sugiyama, Daisuke

AU - Morinobu, Akio

AU - Fukutake, Masaaki

AU - Maeda, Kiyoshi

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