Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population

Shintaro Omori, Yasushi Tanaka, Atsushl Takahashi, Hiroshi Hirose, Atsunori Kashiwagi, Kohei Kaku, Ryuzo Kawamori, Yusuke Nakamura, Shiro Maeda Labo

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215 Citations (Scopus)

Abstract

OBJECTIVE-Recently, several genes have been shown to be associated with an increased risk of type 2 diabetes by genome- wide association studies in white populations. To further investigate the involvement of these polymorphisms in conferring susceptibility to type 2 diabetes, we examined the association of 14 single nucleotide polymorphisms (SNPs) within 11 candidate loci with type 2 diabetes in a Japanese population. RESEARCH DESIGN AND METHODS-We analyzed 14 SNPs (rs4402960 in IGF2BP2, rsl0811661 in CDKN2A/B, rs1111875 and rs7923837 in HHEX, rsl3266634 in SLC30A8, rs1113132 and rs11037909 in EXT2, rs9939609 and rs8050136 in FTO, rs7756992 in CDKAL1, rsl801282 in PPARG Prol2Ara, rs5219 in KCNJ11 Glu23Lys, rs7480010 in LOC387761, and rs9300039 in Ch11) in 1,630 Japanese subjects with type 2 diabetes and in 1,064 control subjects by using an invader assay or a TaqMan assay. RESULTS-Among the 11 loci examined, 6 were significantly associated with type 2 diabetes in our population by a logistic regression analysis, similar to previously reported results (rs4402960, P = 0.00009; rsl0811661, P = 0.0024; rs5219, P = 0.0034; rs1111875, P = 0.0064; rs13266634, P = 0.0073; rs7756992, P = 0.0363). In this population, the remaining five loci were not significantly associated with type 2 diabetes. In addition, we identified significant association of the SNPs in FTO gene with BMI in the control subjects. CONCLUSIONS-We have identified 6 of the 11 loci that were identified by genome-wide association studies in white populations, and these loci are considered strong candidates for type 2 diabetes susceptibility across different ethnicities.

Original languageEnglish
Pages (from-to)791-795
Number of pages5
JournalDiabetes
Volume57
Issue number3
DOIs
Publication statusPublished - 2008 Mar 1

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

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    Omori, S., Tanaka, Y., Takahashi, A., Hirose, H., Kashiwagi, A., Kaku, K., Kawamori, R., Nakamura, Y., & Labo, S. M. (2008). Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population. Diabetes, 57(3), 791-795. https://doi.org/10.2337/db07-0979