TY - JOUR
T1 - Association of common polymorphisms with gestational diabetes mellitus in Japanese women
T2 - A case-control study
AU - Kasuga, Yoshifumi
AU - Hata, Kenichiro
AU - Tajima, Atsushi
AU - Ochiai, Daigo
AU - Saisho, Yoshifumi
AU - Matsumoto, Tadashi
AU - Arata, Naoko
AU - Miyakoshi, Kei
AU - Tanaka, Mamoru
N1 - Funding Information:
This study was supported by Japan Agency for Medical Research and Development Diseases (AMED, 16gm0510011h0205, 16ek0109067h0003, 16gk0110013s0801, 16gk0110018s0601), KAKENHI (26293365 and 26462500), Grants from the NCCHD of Japan (26-13), and a CREST Program of JST (Epigenomic analysis of the human placenta and endo-metrium constituting the fetal-maternal interface). The authors are grateful to all medical staffs at Keio University Hospital for excellent patient care. We also appreciate medical staff in the perinatal unit of National Center for Child Health and Development.
Publisher Copyright:
© The Japan Endocrine Society.
PY - 2017
Y1 - 2017
N2 - Gestational diabetes (GDM) and type 2 diabetes (T2DM) share part of pathomechanism and several T2DM susceptibility genes are demonstrated to be associated with GDM. No information on the genetics of GDM, however, was available in Japanese women. In this study, T2DM risk variants (45 single nucleotide polymorphisms [SNPs] from 36 genes) identified in previous studies were genotyped using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry in a cohort of 171 Japanese women with GDM and 128 normal glucose tolerance (NGT) diagnosed by the new International Association of Diabetes in Pregnancy Study Group criteria. Of 45 SNPs, three genetic variants were nominally associated with the development of GDM: rs266729 (p = 0.013, odds ratio [OR]: 1.56, 95% confidence interval [CI]: 1.10–2.23) in ADIPOQ, rs10811661 (p = 0.035, OR: 1.46, 95% CI: 1.03–2.08) in CDKN2A/2B, and rs9505118 (p = 0.046, OR: 1.41, 95% CI: 1.01–1.97) in SSR1-RREB1. There was a significant difference in the number of risk alleles of three variants between women with GDM and NGT (3.79 ± 1.33 vs. 3.05 ± 1.41, p = 6.0 × 10-6). In combined analysis of three genetic variants, women with five or more risk alleles had a 7.32-fold increased risk of GDM (p = 5.6 × 10-5, 95% CI: 4.54–11.96), compared with those having no more than one risk allele. Our results suggest several risk variants of T2DM had cumulative effects on the development of GDM in Japanese women.
AB - Gestational diabetes (GDM) and type 2 diabetes (T2DM) share part of pathomechanism and several T2DM susceptibility genes are demonstrated to be associated with GDM. No information on the genetics of GDM, however, was available in Japanese women. In this study, T2DM risk variants (45 single nucleotide polymorphisms [SNPs] from 36 genes) identified in previous studies were genotyped using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry in a cohort of 171 Japanese women with GDM and 128 normal glucose tolerance (NGT) diagnosed by the new International Association of Diabetes in Pregnancy Study Group criteria. Of 45 SNPs, three genetic variants were nominally associated with the development of GDM: rs266729 (p = 0.013, odds ratio [OR]: 1.56, 95% confidence interval [CI]: 1.10–2.23) in ADIPOQ, rs10811661 (p = 0.035, OR: 1.46, 95% CI: 1.03–2.08) in CDKN2A/2B, and rs9505118 (p = 0.046, OR: 1.41, 95% CI: 1.01–1.97) in SSR1-RREB1. There was a significant difference in the number of risk alleles of three variants between women with GDM and NGT (3.79 ± 1.33 vs. 3.05 ± 1.41, p = 6.0 × 10-6). In combined analysis of three genetic variants, women with five or more risk alleles had a 7.32-fold increased risk of GDM (p = 5.6 × 10-5, 95% CI: 4.54–11.96), compared with those having no more than one risk allele. Our results suggest several risk variants of T2DM had cumulative effects on the development of GDM in Japanese women.
KW - Gestational diabetes mellitus
KW - Japanese women
KW - Single nucleotide polymorphism
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U2 - 10.1507/endocrj.EJ16-0431
DO - 10.1507/endocrj.EJ16-0431
M3 - Comment/debate
C2 - 28202837
AN - SCOPUS:85018309273
SN - 0918-8959
VL - 64
SP - 463
EP - 475
JO - Endocrine Journal
JF - Endocrine Journal
IS - 4
ER -
