Association of HNPCC and endometrial cancers

Kouji Banno, Nobuyuld Susumu, Megumi Yanokura, Takeshi Hirao, Takashi Iwata, Akira Hirasawa, Daisuke Aoki, Kokichi Sugano, Shiro Nozawa

Research output: Contribution to journalReview article

17 Citations (Scopus)

Abstract

Hereditary nonpolyposis colorectal cancer (HNPCC) is among the representative familial cancers that are autosomally dominant inherited disorders. Because endometrial cancers develop at high rates in women with HNPCC, it is suggested that some endometrial cancers are familial cancers that are induced by mutations of the DNA mismatch repair (MMR) genes, as in HNPCC. To understand the clinical pathology of familial endometrial cancers that are associated with HNPCC, we surveyed the family histories of 385 patients with endometrial cancer and found that 0.5% of endometrial cancers met the new diagnostic criteria of HNPCC. From molecular and biological analyses, we found microsatellite instability in 30.8% of endometrial cancers and germline mutations of MMR genes in 8.3%. These results suggest a close relationship of MMR gene mutations to the development of endometrial cancers. For a better understanding of the clinical pathology of HNPCC-associated familial endometrial cancers, it is critical for gynecologists to perform a large multicenter study, including detailed family histories.

Original languageEnglish
Pages (from-to)262-269
Number of pages8
JournalInternational Journal of Clinical Oncology
Volume9
Issue number4
DOIs
Publication statusPublished - 2004 Aug 1

Keywords

  • Endometrial cancer
  • HNPCC
  • Revised Amsterdam Criteria
  • hMLH1
  • hMSH2

ASJC Scopus subject areas

  • Surgery
  • Hematology
  • Oncology

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  • Cite this

    Banno, K., Susumu, N., Yanokura, M., Hirao, T., Iwata, T., Hirasawa, A., Aoki, D., Sugano, K., & Nozawa, S. (2004). Association of HNPCC and endometrial cancers. International Journal of Clinical Oncology, 9(4), 262-269. https://doi.org/10.1007/s10147-004-0402-8