Association of inflammatory gene polymorphisms and conventional risk factors with arterial stiffness by age

Motahare Kheradmand, Hideshi Niimura, Kazuyo Kuwabara, Noriko Nakahata, Akihiko Nakamura, Shin Ogawa, Eva Mariane Mantjoro, Keiichi Shimatani, Yasuhito Nerome, Tetsuhiro Owaki, Ken Kusano, Toshiro Takezaki

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Inflammatory gene polymorphisms are potentially associated with atherosclerosis risk, but their age- related effects are unclear. To investigate the age-related effects of inflammatory gene polymorphisms on arterial stiffness, we conducted cross-sectional and 5-year follow-up studies using the cardio-ankle vascular index (CAVI) as a surrogate marker of arterial stiffness. Methods: We recruited 1850 adults aged 34 to 69 years from the Japanese general population. Inflammatory gene polymorphisms were selected from NF-kB1, CD14, IL-6, IL-10, MCP-1, ICAM-1, and TNF-a. Associations of CAVI with genetic and conventional risk factors were estimated by sex and age group (34-49, 50-59, and 60-69 years) using a general linear model. The association with 5-year change in CAVI was examined longitudinally. Results: Glucose intolerance was associated with high CAVI among women in all age groups, while hypertension was associated with high CAVI among participants in all age groups, except younger women. Mean CAVI for the CD14 CC genotype was lower than those for the TT and CT genotypes (P for trend = 0.005), while the CD14 polymorphism was associated with CAVI only among men aged 34 to 49 years (P = 0.006). No association of the other 6 polymorphisms with CAVI was observed. No association with 5-year change in CAVI was apparent. Conclusions: Inflammatory gene polymorphisms were not associated with arterial stiffness. To confirm these results, further large-scale prospective studies are warranted.

Original languageEnglish
Pages (from-to)457-465
Number of pages9
JournalJournal of Epidemiology
Volume23
Issue number6
DOIs
Publication statusPublished - 2013 Aug 31
Externally publishedYes

Fingerprint

Vascular Stiffness
Ankle
Blood Vessels
Genes
Age Groups
Genotype
Glucose Intolerance
Intercellular Adhesion Molecule-1
Interleukin-10
Linear Models
Interleukin-6
Atherosclerosis
Biomarkers
Prospective Studies
Hypertension

Keywords

  • Atherosclerosis
  • Cardio-ankle vascular index
  • Gene polymorphism
  • Inflammation

ASJC Scopus subject areas

  • Epidemiology

Cite this

Association of inflammatory gene polymorphisms and conventional risk factors with arterial stiffness by age. / Kheradmand, Motahare; Niimura, Hideshi; Kuwabara, Kazuyo; Nakahata, Noriko; Nakamura, Akihiko; Ogawa, Shin; Mantjoro, Eva Mariane; Shimatani, Keiichi; Nerome, Yasuhito; Owaki, Tetsuhiro; Kusano, Ken; Takezaki, Toshiro.

In: Journal of Epidemiology, Vol. 23, No. 6, 31.08.2013, p. 457-465.

Research output: Contribution to journalArticle

Kheradmand, M, Niimura, H, Kuwabara, K, Nakahata, N, Nakamura, A, Ogawa, S, Mantjoro, EM, Shimatani, K, Nerome, Y, Owaki, T, Kusano, K & Takezaki, T 2013, 'Association of inflammatory gene polymorphisms and conventional risk factors with arterial stiffness by age', Journal of Epidemiology, vol. 23, no. 6, pp. 457-465. https://doi.org/10.2188/jea.JE20130054
Kheradmand, Motahare ; Niimura, Hideshi ; Kuwabara, Kazuyo ; Nakahata, Noriko ; Nakamura, Akihiko ; Ogawa, Shin ; Mantjoro, Eva Mariane ; Shimatani, Keiichi ; Nerome, Yasuhito ; Owaki, Tetsuhiro ; Kusano, Ken ; Takezaki, Toshiro. / Association of inflammatory gene polymorphisms and conventional risk factors with arterial stiffness by age. In: Journal of Epidemiology. 2013 ; Vol. 23, No. 6. pp. 457-465.
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AU - Kheradmand, Motahare

AU - Niimura, Hideshi

AU - Kuwabara, Kazuyo

AU - Nakahata, Noriko

AU - Nakamura, Akihiko

AU - Ogawa, Shin

AU - Mantjoro, Eva Mariane

AU - Shimatani, Keiichi

AU - Nerome, Yasuhito

AU - Owaki, Tetsuhiro

AU - Kusano, Ken

AU - Takezaki, Toshiro

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Y1 - 2013/8/31

N2 - Background: Inflammatory gene polymorphisms are potentially associated with atherosclerosis risk, but their age- related effects are unclear. To investigate the age-related effects of inflammatory gene polymorphisms on arterial stiffness, we conducted cross-sectional and 5-year follow-up studies using the cardio-ankle vascular index (CAVI) as a surrogate marker of arterial stiffness. Methods: We recruited 1850 adults aged 34 to 69 years from the Japanese general population. Inflammatory gene polymorphisms were selected from NF-kB1, CD14, IL-6, IL-10, MCP-1, ICAM-1, and TNF-a. Associations of CAVI with genetic and conventional risk factors were estimated by sex and age group (34-49, 50-59, and 60-69 years) using a general linear model. The association with 5-year change in CAVI was examined longitudinally. Results: Glucose intolerance was associated with high CAVI among women in all age groups, while hypertension was associated with high CAVI among participants in all age groups, except younger women. Mean CAVI for the CD14 CC genotype was lower than those for the TT and CT genotypes (P for trend = 0.005), while the CD14 polymorphism was associated with CAVI only among men aged 34 to 49 years (P = 0.006). No association of the other 6 polymorphisms with CAVI was observed. No association with 5-year change in CAVI was apparent. Conclusions: Inflammatory gene polymorphisms were not associated with arterial stiffness. To confirm these results, further large-scale prospective studies are warranted.

AB - Background: Inflammatory gene polymorphisms are potentially associated with atherosclerosis risk, but their age- related effects are unclear. To investigate the age-related effects of inflammatory gene polymorphisms on arterial stiffness, we conducted cross-sectional and 5-year follow-up studies using the cardio-ankle vascular index (CAVI) as a surrogate marker of arterial stiffness. Methods: We recruited 1850 adults aged 34 to 69 years from the Japanese general population. Inflammatory gene polymorphisms were selected from NF-kB1, CD14, IL-6, IL-10, MCP-1, ICAM-1, and TNF-a. Associations of CAVI with genetic and conventional risk factors were estimated by sex and age group (34-49, 50-59, and 60-69 years) using a general linear model. The association with 5-year change in CAVI was examined longitudinally. Results: Glucose intolerance was associated with high CAVI among women in all age groups, while hypertension was associated with high CAVI among participants in all age groups, except younger women. Mean CAVI for the CD14 CC genotype was lower than those for the TT and CT genotypes (P for trend = 0.005), while the CD14 polymorphism was associated with CAVI only among men aged 34 to 49 years (P = 0.006). No association of the other 6 polymorphisms with CAVI was observed. No association with 5-year change in CAVI was apparent. Conclusions: Inflammatory gene polymorphisms were not associated with arterial stiffness. To confirm these results, further large-scale prospective studies are warranted.

KW - Atherosclerosis

KW - Cardio-ankle vascular index

KW - Gene polymorphism

KW - Inflammation

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