TY - JOUR
T1 - Association of inflammatory gene polymorphisms and conventional risk factors with arterial stiffness by age
AU - Kheradmand, Motahare
AU - Niimura, Hideshi
AU - Kuwabara, Kazuyo
AU - Nakahata, Noriko
AU - Nakamura, Akihiko
AU - Ogawa, Shin
AU - Mantjoro, Eva Mariane
AU - Shimatani, Keiichi
AU - Nerome, Yasuhito
AU - Owaki, Tetsuhiro
AU - Kusano, Ken
AU - Takezaki, Toshiro
PY - 2013/8/31
Y1 - 2013/8/31
N2 - Background: Inflammatory gene polymorphisms are potentially associated with atherosclerosis risk, but their age- related effects are unclear. To investigate the age-related effects of inflammatory gene polymorphisms on arterial stiffness, we conducted cross-sectional and 5-year follow-up studies using the cardio-ankle vascular index (CAVI) as a surrogate marker of arterial stiffness. Methods: We recruited 1850 adults aged 34 to 69 years from the Japanese general population. Inflammatory gene polymorphisms were selected from NF-kB1, CD14, IL-6, IL-10, MCP-1, ICAM-1, and TNF-a. Associations of CAVI with genetic and conventional risk factors were estimated by sex and age group (34-49, 50-59, and 60-69 years) using a general linear model. The association with 5-year change in CAVI was examined longitudinally. Results: Glucose intolerance was associated with high CAVI among women in all age groups, while hypertension was associated with high CAVI among participants in all age groups, except younger women. Mean CAVI for the CD14 CC genotype was lower than those for the TT and CT genotypes (P for trend = 0.005), while the CD14 polymorphism was associated with CAVI only among men aged 34 to 49 years (P = 0.006). No association of the other 6 polymorphisms with CAVI was observed. No association with 5-year change in CAVI was apparent. Conclusions: Inflammatory gene polymorphisms were not associated with arterial stiffness. To confirm these results, further large-scale prospective studies are warranted.
AB - Background: Inflammatory gene polymorphisms are potentially associated with atherosclerosis risk, but their age- related effects are unclear. To investigate the age-related effects of inflammatory gene polymorphisms on arterial stiffness, we conducted cross-sectional and 5-year follow-up studies using the cardio-ankle vascular index (CAVI) as a surrogate marker of arterial stiffness. Methods: We recruited 1850 adults aged 34 to 69 years from the Japanese general population. Inflammatory gene polymorphisms were selected from NF-kB1, CD14, IL-6, IL-10, MCP-1, ICAM-1, and TNF-a. Associations of CAVI with genetic and conventional risk factors were estimated by sex and age group (34-49, 50-59, and 60-69 years) using a general linear model. The association with 5-year change in CAVI was examined longitudinally. Results: Glucose intolerance was associated with high CAVI among women in all age groups, while hypertension was associated with high CAVI among participants in all age groups, except younger women. Mean CAVI for the CD14 CC genotype was lower than those for the TT and CT genotypes (P for trend = 0.005), while the CD14 polymorphism was associated with CAVI only among men aged 34 to 49 years (P = 0.006). No association of the other 6 polymorphisms with CAVI was observed. No association with 5-year change in CAVI was apparent. Conclusions: Inflammatory gene polymorphisms were not associated with arterial stiffness. To confirm these results, further large-scale prospective studies are warranted.
KW - Atherosclerosis
KW - Cardio-ankle vascular index
KW - Gene polymorphism
KW - Inflammation
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U2 - 10.2188/jea.JE20130054
DO - 10.2188/jea.JE20130054
M3 - Article
C2 - 24077340
AN - SCOPUS:84888043236
SN - 0917-5040
VL - 23
SP - 457
EP - 465
JO - Journal of Epidemiology
JF - Journal of Epidemiology
IS - 6
ER -