Association of intima-media thickening of carotid artery with genetic polymorphisms of the regulator of G-protein signaling 2 gene in patients with hypertension and in the general population

Kei Kamide, Yoshihiro Kokubo, Jin Yang, Shin Takiuchi, Takeshi Horio, Sachiko Matsumoto, Mariko Banno, Tetsutaro Matayoshi, Hisayo Yasuda, Yoshikazu Miwa, Fumiki Yoshihara, Satoko Nakamura, Hajime Nakahama, Yoshio Iwashima, Ryousuke Oguro, Mitsuru Ohishi, Hiromi Rakugi, Tomonori Okamura, Toshiyuki Miyata, Yuhei Kawano

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Regulator of G-protein signaling 2 (RGS2) is a key molecule in signal pathways of vasoactive peptides, such as angiotensin II and endothelin 1, and is believed to have an important role in the pathophysiology of atherosclerosis. We have previously reported that common polymorphisms of RGS2 are associated with hypertension in Japanese. In this study, we studied whether the three previously identified common polymorphisms of RGS2 (638AG, 1026TA and 1891-1892delTC) could be implicated in carotid atherosclerosis in Japanese patients with hypertension (459 men and 382 woman) and in a Japanese general population (814 men and 956 woman). We assessed two criteria for carotid atherosclerosis: maximal intima-media thickness (M-IMT) and mean-IMT. When subjects with atherosclerotic lesions were defined as having mean-IMT1.0 mm, multivariate logistic regression analysis performed after adjusting for confounding factors showed a significant association of the three common polymorphisms, 638AG (AA versus AGGG: odds ratio (OR), 1.55; 95% confidence interval (CI), 1.105-2.185; P0.0113 only for the general population), 1026TA (TT versus TAAA: OR, 1.42; 95% CI, 1.027-1.972; P0.034 for hypertensive subjects and OR, 1.56; 95% CI, 1.129-2.151; P0.0071 for the general population), and 1891-1892delTC (II versus IDDD: OR, 1.44; 95% CI, 1.043-2.008; P0.028 for hypertensive subjects, OR, 1.32; 95% CI 1.002-1.742; P0.048 for the total general population and OR 1.59; 95% CI 1.155-2.207; P0.0047 for the general population), with carotid atherosclerosis. When atherosclerosis was defined as M-IMT 1.0 mm, the values of M-IMT were also significantly different between the three genotypes in the three common polymorphisms. Taken together, these data suggest that genetic polymorphisms in RGS2 are associated with intima-media thickening of carotid artery in humans.

Original languageEnglish
Pages (from-to)740-746
Number of pages7
JournalHypertension Research
Volume34
Issue number6
DOIs
Publication statusPublished - 2011 Jun 1
Externally publishedYes

Keywords

  • RGS2
  • intima-media thickening of carotid artery
  • single nucleotide polymorphisms

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

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  • Cite this

    Kamide, K., Kokubo, Y., Yang, J., Takiuchi, S., Horio, T., Matsumoto, S., Banno, M., Matayoshi, T., Yasuda, H., Miwa, Y., Yoshihara, F., Nakamura, S., Nakahama, H., Iwashima, Y., Oguro, R., Ohishi, M., Rakugi, H., Okamura, T., Miyata, T., & Kawano, Y. (2011). Association of intima-media thickening of carotid artery with genetic polymorphisms of the regulator of G-protein signaling 2 gene in patients with hypertension and in the general population. Hypertension Research, 34(6), 740-746. https://doi.org/10.1038/hr.2011.25