Association of kidney dysfunction with asymptomatic cerebrovascular abnormalities in a Japanese population with health checkups

Kaori Hayashi, Michiyo Takayama, Takeshi Kanda, Kazuhiro Kashiwagi, Akihito Hishikawa, Yasushi Iwao, Hiroshi Itoh

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Cerebrovascular disease is a major cause of mortality and morbidity. Chronic kidney disease (CKD) is prevalent in stroke patients. This study evaluated the correlation between kidney dysfunction and asymptomatic findings on carotid ultrasonography (US) and brain magnetic resonance imaging (MRI) in a Japanese population with health checkups. Methods and Results: In total, 1,716 subjects aged 40–80 years, who received health checkups from January 1 to December 31, 2015, were included. Common carotid artery intima–media thickness (CCA-IMT) and carotid plaques by US, and the presence of old non-lacunar infarctions, lacunar infarctions, white matter lesions (WMLs), cerebral microbleeds (CMBs), and atrophy by brain MRI were evaluated. After adjusting for cardiovascular risk factors, multiple regression analyses revealed that an eGFR ranging from 15 to 44 mL/min/1.73 m2 was independently associated with CCA plaques and hypoechoic or heterogeneous plaques. Proteinuria was associated with CCA or internal carotid artery plaques, the number of carotid plaques, and the presence of old non-lacunar infarctions and CMBs. Conclusions: Decreased eGFR and proteinuria were independent risk factors for asymptomatic abnormalities on carotid US and brain MRI, which are surrogate markers for cerebrovascular diseases. Evaluation of these abnormalities may be useful for prevention of symptomatic cerebrovascular events in CKD patients.

Original languageEnglish
Pages (from-to)1191-1197
Number of pages7
JournalCirculation Journal
Volume81
Issue number8
DOIs
Publication statusPublished - 2017

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Cerebrovascular Disorders
Ultrasonography
Magnetic Resonance Imaging
Chronic Renal Insufficiency
Kidney
Proteinuria
Health
Brain
Population
Lacunar Stroke
Carotid Stenosis
Common Carotid Artery
Cerebral Infarction
Internal Carotid Artery
Infarction
Atrophy
Biomarkers
Stroke
Regression Analysis
Morbidity

Keywords

  • Carotid plaque
  • Cerebral microbleeds
  • eGFR
  • Proteinuria

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

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title = "Association of kidney dysfunction with asymptomatic cerebrovascular abnormalities in a Japanese population with health checkups",
abstract = "Background: Cerebrovascular disease is a major cause of mortality and morbidity. Chronic kidney disease (CKD) is prevalent in stroke patients. This study evaluated the correlation between kidney dysfunction and asymptomatic findings on carotid ultrasonography (US) and brain magnetic resonance imaging (MRI) in a Japanese population with health checkups. Methods and Results: In total, 1,716 subjects aged 40–80 years, who received health checkups from January 1 to December 31, 2015, were included. Common carotid artery intima–media thickness (CCA-IMT) and carotid plaques by US, and the presence of old non-lacunar infarctions, lacunar infarctions, white matter lesions (WMLs), cerebral microbleeds (CMBs), and atrophy by brain MRI were evaluated. After adjusting for cardiovascular risk factors, multiple regression analyses revealed that an eGFR ranging from 15 to 44 mL/min/1.73 m2 was independently associated with CCA plaques and hypoechoic or heterogeneous plaques. Proteinuria was associated with CCA or internal carotid artery plaques, the number of carotid plaques, and the presence of old non-lacunar infarctions and CMBs. Conclusions: Decreased eGFR and proteinuria were independent risk factors for asymptomatic abnormalities on carotid US and brain MRI, which are surrogate markers for cerebrovascular diseases. Evaluation of these abnormalities may be useful for prevention of symptomatic cerebrovascular events in CKD patients.",
keywords = "Carotid plaque, Cerebral microbleeds, eGFR, Proteinuria",
author = "Kaori Hayashi and Michiyo Takayama and Takeshi Kanda and Kazuhiro Kashiwagi and Akihito Hishikawa and Yasushi Iwao and Hiroshi Itoh",
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T1 - Association of kidney dysfunction with asymptomatic cerebrovascular abnormalities in a Japanese population with health checkups

AU - Hayashi, Kaori

AU - Takayama, Michiyo

AU - Kanda, Takeshi

AU - Kashiwagi, Kazuhiro

AU - Hishikawa, Akihito

AU - Iwao, Yasushi

AU - Itoh, Hiroshi

PY - 2017

Y1 - 2017

N2 - Background: Cerebrovascular disease is a major cause of mortality and morbidity. Chronic kidney disease (CKD) is prevalent in stroke patients. This study evaluated the correlation between kidney dysfunction and asymptomatic findings on carotid ultrasonography (US) and brain magnetic resonance imaging (MRI) in a Japanese population with health checkups. Methods and Results: In total, 1,716 subjects aged 40–80 years, who received health checkups from January 1 to December 31, 2015, were included. Common carotid artery intima–media thickness (CCA-IMT) and carotid plaques by US, and the presence of old non-lacunar infarctions, lacunar infarctions, white matter lesions (WMLs), cerebral microbleeds (CMBs), and atrophy by brain MRI were evaluated. After adjusting for cardiovascular risk factors, multiple regression analyses revealed that an eGFR ranging from 15 to 44 mL/min/1.73 m2 was independently associated with CCA plaques and hypoechoic or heterogeneous plaques. Proteinuria was associated with CCA or internal carotid artery plaques, the number of carotid plaques, and the presence of old non-lacunar infarctions and CMBs. Conclusions: Decreased eGFR and proteinuria were independent risk factors for asymptomatic abnormalities on carotid US and brain MRI, which are surrogate markers for cerebrovascular diseases. Evaluation of these abnormalities may be useful for prevention of symptomatic cerebrovascular events in CKD patients.

AB - Background: Cerebrovascular disease is a major cause of mortality and morbidity. Chronic kidney disease (CKD) is prevalent in stroke patients. This study evaluated the correlation between kidney dysfunction and asymptomatic findings on carotid ultrasonography (US) and brain magnetic resonance imaging (MRI) in a Japanese population with health checkups. Methods and Results: In total, 1,716 subjects aged 40–80 years, who received health checkups from January 1 to December 31, 2015, were included. Common carotid artery intima–media thickness (CCA-IMT) and carotid plaques by US, and the presence of old non-lacunar infarctions, lacunar infarctions, white matter lesions (WMLs), cerebral microbleeds (CMBs), and atrophy by brain MRI were evaluated. After adjusting for cardiovascular risk factors, multiple regression analyses revealed that an eGFR ranging from 15 to 44 mL/min/1.73 m2 was independently associated with CCA plaques and hypoechoic or heterogeneous plaques. Proteinuria was associated with CCA or internal carotid artery plaques, the number of carotid plaques, and the presence of old non-lacunar infarctions and CMBs. Conclusions: Decreased eGFR and proteinuria were independent risk factors for asymptomatic abnormalities on carotid US and brain MRI, which are surrogate markers for cerebrovascular diseases. Evaluation of these abnormalities may be useful for prevention of symptomatic cerebrovascular events in CKD patients.

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KW - Cerebral microbleeds

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