Association of lipoprotein-associated phospholipase A2 with coronary calcification among American and Japanese men

Aiman El-Saed, Akira Sekikawa, Riad Wahid Zaky, Takashi Kadowaki, Tomoko Takamiya, Tomonori Okamura, Daniel Edmundowicz, Yoshikuni Kita, Lewis H. Kuller, Hirotsugu Ueshima

Research output: Contribution to journalArticle

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Abstract

Background: We have previously reported that the prevalence of coronary artery calcification (CAC) was substantially lower among Japanese than American men despite a less favorable profile of many traditional risk factors in Japanese men. To determine whether lipoprotein-associated phospholipase A2 (Lp-PLA2) levels are related to the difference in the prevalence of CAC between the two populations. Methods: A total of 200 men aged 40-49 years were examined: 100 residents in Allegheny County, Pennsylvania, United States, and 100 residents in Kusatsu City, Shiga, Japan. Coronary calcium score (CCS) was evaluated by electron-beam tomography, Lp-PLA2 levels, nuclear magnetic resonance (NMR) lipoprotein subclasses, and other factors were assessed in 2001-2002. Results: Lp-PLA2 levels were higher among American than Japanese men (Mean ± standard deviation 301.7 ± 82.6 versus 275.9 ± 104.7 ng/mL, respectively, p=0.06). Among all Japanese men and those with low density lipoprotein (LDL) cholesterol ≥130 mg/dL, there was an inverse association of the prevalence of CCS>0 with the tertile groups of Lp-PLA2 levels (p=0.08 and p=0.03, respectively). American men did not have any association between CCS>0 with the tertile groups of Lp-PLA2 (p=0.62). Although Lp-PLA2 among both populations correlated positively with LDL and total cholesterol, American and Japanese men had different correlations with NMR lipoprotein subclasses. Reported high odds ratio for CCS>0 among American compared to Japanese men was not reduced after adjusting for Lp-PLA2 levels. Conclusion: Lp-PLA2 may have different mechanisms of action among American and Japanese men. Lp-PLA2 levels can not explain the observed CAC differences between the two populations.

Original languageEnglish
Pages (from-to)179-185
Number of pages7
JournalJournal of Epidemiology
Volume17
Issue number6
DOIs
Publication statusPublished - 2007 Dec 19
Externally publishedYes

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1-Alkyl-2-acetylglycerophosphocholine Esterase
Calcium
Coronary Vessels
LDL Cholesterol
Lipoproteins
Magnetic Resonance Spectroscopy
Population
X Ray Computed Tomography
Asian Americans
Japan
Odds Ratio

Keywords

  • 1-Alkyl-2-acetylglycerophosphocholine esterase
  • Asian continental ancestry group
  • Atherosclerosis
  • Calcification
  • Coronary arteriosclerosis
  • European Continental Ancestry Group

ASJC Scopus subject areas

  • Epidemiology

Cite this

Association of lipoprotein-associated phospholipase A2 with coronary calcification among American and Japanese men. / El-Saed, Aiman; Sekikawa, Akira; Zaky, Riad Wahid; Kadowaki, Takashi; Takamiya, Tomoko; Okamura, Tomonori; Edmundowicz, Daniel; Kita, Yoshikuni; Kuller, Lewis H.; Ueshima, Hirotsugu.

In: Journal of Epidemiology, Vol. 17, No. 6, 19.12.2007, p. 179-185.

Research output: Contribution to journalArticle

El-Saed, A, Sekikawa, A, Zaky, RW, Kadowaki, T, Takamiya, T, Okamura, T, Edmundowicz, D, Kita, Y, Kuller, LH & Ueshima, H 2007, 'Association of lipoprotein-associated phospholipase A2 with coronary calcification among American and Japanese men', Journal of Epidemiology, vol. 17, no. 6, pp. 179-185. https://doi.org/10.2188/jea.17.179
El-Saed, Aiman ; Sekikawa, Akira ; Zaky, Riad Wahid ; Kadowaki, Takashi ; Takamiya, Tomoko ; Okamura, Tomonori ; Edmundowicz, Daniel ; Kita, Yoshikuni ; Kuller, Lewis H. ; Ueshima, Hirotsugu. / Association of lipoprotein-associated phospholipase A2 with coronary calcification among American and Japanese men. In: Journal of Epidemiology. 2007 ; Vol. 17, No. 6. pp. 179-185.
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abstract = "Background: We have previously reported that the prevalence of coronary artery calcification (CAC) was substantially lower among Japanese than American men despite a less favorable profile of many traditional risk factors in Japanese men. To determine whether lipoprotein-associated phospholipase A2 (Lp-PLA2) levels are related to the difference in the prevalence of CAC between the two populations. Methods: A total of 200 men aged 40-49 years were examined: 100 residents in Allegheny County, Pennsylvania, United States, and 100 residents in Kusatsu City, Shiga, Japan. Coronary calcium score (CCS) was evaluated by electron-beam tomography, Lp-PLA2 levels, nuclear magnetic resonance (NMR) lipoprotein subclasses, and other factors were assessed in 2001-2002. Results: Lp-PLA2 levels were higher among American than Japanese men (Mean ± standard deviation 301.7 ± 82.6 versus 275.9 ± 104.7 ng/mL, respectively, p=0.06). Among all Japanese men and those with low density lipoprotein (LDL) cholesterol ≥130 mg/dL, there was an inverse association of the prevalence of CCS>0 with the tertile groups of Lp-PLA2 levels (p=0.08 and p=0.03, respectively). American men did not have any association between CCS>0 with the tertile groups of Lp-PLA2 (p=0.62). Although Lp-PLA2 among both populations correlated positively with LDL and total cholesterol, American and Japanese men had different correlations with NMR lipoprotein subclasses. Reported high odds ratio for CCS>0 among American compared to Japanese men was not reduced after adjusting for Lp-PLA2 levels. Conclusion: Lp-PLA2 may have different mechanisms of action among American and Japanese men. Lp-PLA2 levels can not explain the observed CAC differences between the two populations.",
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AU - Sekikawa, Akira

AU - Zaky, Riad Wahid

AU - Kadowaki, Takashi

AU - Takamiya, Tomoko

AU - Okamura, Tomonori

AU - Edmundowicz, Daniel

AU - Kita, Yoshikuni

AU - Kuller, Lewis H.

AU - Ueshima, Hirotsugu

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N2 - Background: We have previously reported that the prevalence of coronary artery calcification (CAC) was substantially lower among Japanese than American men despite a less favorable profile of many traditional risk factors in Japanese men. To determine whether lipoprotein-associated phospholipase A2 (Lp-PLA2) levels are related to the difference in the prevalence of CAC between the two populations. Methods: A total of 200 men aged 40-49 years were examined: 100 residents in Allegheny County, Pennsylvania, United States, and 100 residents in Kusatsu City, Shiga, Japan. Coronary calcium score (CCS) was evaluated by electron-beam tomography, Lp-PLA2 levels, nuclear magnetic resonance (NMR) lipoprotein subclasses, and other factors were assessed in 2001-2002. Results: Lp-PLA2 levels were higher among American than Japanese men (Mean ± standard deviation 301.7 ± 82.6 versus 275.9 ± 104.7 ng/mL, respectively, p=0.06). Among all Japanese men and those with low density lipoprotein (LDL) cholesterol ≥130 mg/dL, there was an inverse association of the prevalence of CCS>0 with the tertile groups of Lp-PLA2 levels (p=0.08 and p=0.03, respectively). American men did not have any association between CCS>0 with the tertile groups of Lp-PLA2 (p=0.62). Although Lp-PLA2 among both populations correlated positively with LDL and total cholesterol, American and Japanese men had different correlations with NMR lipoprotein subclasses. Reported high odds ratio for CCS>0 among American compared to Japanese men was not reduced after adjusting for Lp-PLA2 levels. Conclusion: Lp-PLA2 may have different mechanisms of action among American and Japanese men. Lp-PLA2 levels can not explain the observed CAC differences between the two populations.

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