Association of macular pigment optical density with serum concentration of oxidized low-density lipoprotein in healthy adults

Norihiro Nagai, Kanako Izumi-Nagai, Misa Suzuki, Hajime Shinoda, Takashi Koto, Atsuro Uchida, Hiroshi Mochimaru, Yohei Tomita, Seiji Miyake, Saori Kobayashi, Mariko Sasaki, Kazuo Tsubota, Yoko Ozawa

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9 Citations (Scopus)

Abstract

Purpose: To analyze the association between macular pigment optical density (MPOD), which reflects lutein (L), zeaxanthin (Z), and meso-zeaxanthin (MZ) in the macula, and background characteristics. Methods: Fifty-five healthy adult volunteers were analyzed. Macular pigment optical density was measured using a heterochromatic flicker photometry technique, and serum concentrations of carotenoids and lipoproteins were by high-performance liquid chromatography and enzyme-linked immunosorbent assay, respectively. Dietary intake of nutrient was determined by a validated self-administered questionnaire on ingestion frequency. Results: Macular pigment optical density was positively correlated with serum concentrations of L and Z and dietary L intake and inversely correlated with serum oxidized low-density lipoprotein (LDL). Although MPOD decreased with age (95% confidence interval, -0.011 to -0.002; correlation coefficient, -0.269; P 0.007), serum L/Z and dietary L intake did not. In contrast, serum oxidized LDL was positively correlated with age (95% confidence interval, 0.69-2.34; correlation coefficient, 0.333; P 0.0004). After adjusting for age, sex, and oxidized LDL, serum L was positively correlated with MPOD (95% confidence interval, 0.88-1.69; P 0.000001). After adjusting for age, sex, and serum L, serum oxidized LDL was inversely correlated with MPOD (95% confidence interval, -0.002 to -0.0004; P 0.006). Conclusion: Macular pigment optical density was inversely correlated with serum oxidized LDL. Further study to know the impact of oxidized LDL on MPOD may be warranted.

Original languageEnglish
Pages (from-to)820-826
Number of pages7
JournalRetina
Volume35
Issue number4
DOIs
Publication statusPublished - 2015 Apr 1

Keywords

  • lutein
  • macular pigment
  • oxidized LDL

ASJC Scopus subject areas

  • Ophthalmology

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    Nagai, N., Izumi-Nagai, K., Suzuki, M., Shinoda, H., Koto, T., Uchida, A., Mochimaru, H., Tomita, Y., Miyake, S., Kobayashi, S., Sasaki, M., Tsubota, K., & Ozawa, Y. (2015). Association of macular pigment optical density with serum concentration of oxidized low-density lipoprotein in healthy adults. Retina, 35(4), 820-826. https://doi.org/10.1097/IAE.0000000000000382