Association of marine-origin N-3 polyunsaturated fatty acids consumption and functional mobility in the community-dwelling oldest old

Michiyo Takayama, Yasumichi Arai, S. Sasaki, M. Hashimoto, K. Shimizu, Y. Abe, N. Hirose

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Objective: To examine whether habitual dietary intake of marine-origin n-3 polyunsaturated fatty acids (MOPUFA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are associated with functional mobility in the community-dwelling oldest old, 85 years or older, who are at high risk for physical disability. Design: A cross-sectional study. Setting: A community-based survey conducted at university research center or home-based. Participants: Four hundred seventeen (189 men, 228 women) out of 542 participants in the baseline examination of the Tokyo Oldest Old Survey on Total Health, a community-based ongoing longitudinal study among the oldest old living in the center of Japan. Measurements: Habitual dietary intake of MOPUFA was assessed by the brief-type self-administered diet history questionnaire (BDHQ), and functional mobility was assessed by the Timed Up and Go test. Plasma inflammatory biomarkers (C-reactive protein, interleukin-6 and tumor necrosis factor-a) were measured. We evaluated the cross-sectional association between habitual intake of MOPUFA and functional mobility using multivariate logistic regression analysis - Prior to the analysis, validation of BDHQ in this study was confirmed among 190 participants (96 men, 94 women) based on the EPA and DHA concentrations in the erythrocyte membrane phospholipids as reference. Results: Moderate correlation between estimated dietary intake of EPA/DHA and concentration of EPA/DHA in the erythrocyte membrane phospholipids was obtained (Spearman's r=0.29-0.58, p<0.01). Multivariate logistic regression analysis revealed that a lower habitual intake of EPA+DHA was significantly associated with poor functional mobility in men but not in women (OR (95%CI) per 1 SD increase of EPA+DHA intake; 0.55 (0.33-0.91), 0.88 (0.59-1.32), men and women respectively). Conclusions: Habitual intake of MOPUFA was associated with functional mobility in community-dwelling oldest old men.

Original languageEnglish
Pages (from-to)82-89
Number of pages8
JournalJournal of Nutrition, Health and Aging
Volume17
Issue number1
DOIs
Publication statusPublished - 2013 Jan

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Independent Living
Eicosapentaenoic Acid
Docosahexaenoic Acids
Omega-3 Fatty Acids
Erythrocyte Membrane
Phospholipids
Logistic Models
Regression Analysis
Diet
Tokyo
C-Reactive Protein
Longitudinal Studies
Interleukin-6
Japan
Tumor Necrosis Factor-alpha
Cross-Sectional Studies
Biomarkers
Surveys and Questionnaires
Health
Research

Keywords

  • community-dwelling oldest old
  • diet history questionnaire
  • functional mobility
  • n-3 polyunsaturated fatty acids
  • Timed Up and Go test

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Geriatrics and Gerontology

Cite this

Association of marine-origin N-3 polyunsaturated fatty acids consumption and functional mobility in the community-dwelling oldest old. / Takayama, Michiyo; Arai, Yasumichi; Sasaki, S.; Hashimoto, M.; Shimizu, K.; Abe, Y.; Hirose, N.

In: Journal of Nutrition, Health and Aging, Vol. 17, No. 1, 01.2013, p. 82-89.

Research output: Contribution to journalArticle

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abstract = "Objective: To examine whether habitual dietary intake of marine-origin n-3 polyunsaturated fatty acids (MOPUFA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are associated with functional mobility in the community-dwelling oldest old, 85 years or older, who are at high risk for physical disability. Design: A cross-sectional study. Setting: A community-based survey conducted at university research center or home-based. Participants: Four hundred seventeen (189 men, 228 women) out of 542 participants in the baseline examination of the Tokyo Oldest Old Survey on Total Health, a community-based ongoing longitudinal study among the oldest old living in the center of Japan. Measurements: Habitual dietary intake of MOPUFA was assessed by the brief-type self-administered diet history questionnaire (BDHQ), and functional mobility was assessed by the Timed Up and Go test. Plasma inflammatory biomarkers (C-reactive protein, interleukin-6 and tumor necrosis factor-a) were measured. We evaluated the cross-sectional association between habitual intake of MOPUFA and functional mobility using multivariate logistic regression analysis - Prior to the analysis, validation of BDHQ in this study was confirmed among 190 participants (96 men, 94 women) based on the EPA and DHA concentrations in the erythrocyte membrane phospholipids as reference. Results: Moderate correlation between estimated dietary intake of EPA/DHA and concentration of EPA/DHA in the erythrocyte membrane phospholipids was obtained (Spearman's r=0.29-0.58, p<0.01). Multivariate logistic regression analysis revealed that a lower habitual intake of EPA+DHA was significantly associated with poor functional mobility in men but not in women (OR (95{\%}CI) per 1 SD increase of EPA+DHA intake; 0.55 (0.33-0.91), 0.88 (0.59-1.32), men and women respectively). Conclusions: Habitual intake of MOPUFA was associated with functional mobility in community-dwelling oldest old men.",
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AU - Takayama, Michiyo

AU - Arai, Yasumichi

AU - Sasaki, S.

AU - Hashimoto, M.

AU - Shimizu, K.

AU - Abe, Y.

AU - Hirose, N.

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N2 - Objective: To examine whether habitual dietary intake of marine-origin n-3 polyunsaturated fatty acids (MOPUFA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are associated with functional mobility in the community-dwelling oldest old, 85 years or older, who are at high risk for physical disability. Design: A cross-sectional study. Setting: A community-based survey conducted at university research center or home-based. Participants: Four hundred seventeen (189 men, 228 women) out of 542 participants in the baseline examination of the Tokyo Oldest Old Survey on Total Health, a community-based ongoing longitudinal study among the oldest old living in the center of Japan. Measurements: Habitual dietary intake of MOPUFA was assessed by the brief-type self-administered diet history questionnaire (BDHQ), and functional mobility was assessed by the Timed Up and Go test. Plasma inflammatory biomarkers (C-reactive protein, interleukin-6 and tumor necrosis factor-a) were measured. We evaluated the cross-sectional association between habitual intake of MOPUFA and functional mobility using multivariate logistic regression analysis - Prior to the analysis, validation of BDHQ in this study was confirmed among 190 participants (96 men, 94 women) based on the EPA and DHA concentrations in the erythrocyte membrane phospholipids as reference. Results: Moderate correlation between estimated dietary intake of EPA/DHA and concentration of EPA/DHA in the erythrocyte membrane phospholipids was obtained (Spearman's r=0.29-0.58, p<0.01). Multivariate logistic regression analysis revealed that a lower habitual intake of EPA+DHA was significantly associated with poor functional mobility in men but not in women (OR (95%CI) per 1 SD increase of EPA+DHA intake; 0.55 (0.33-0.91), 0.88 (0.59-1.32), men and women respectively). Conclusions: Habitual intake of MOPUFA was associated with functional mobility in community-dwelling oldest old men.

AB - Objective: To examine whether habitual dietary intake of marine-origin n-3 polyunsaturated fatty acids (MOPUFA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are associated with functional mobility in the community-dwelling oldest old, 85 years or older, who are at high risk for physical disability. Design: A cross-sectional study. Setting: A community-based survey conducted at university research center or home-based. Participants: Four hundred seventeen (189 men, 228 women) out of 542 participants in the baseline examination of the Tokyo Oldest Old Survey on Total Health, a community-based ongoing longitudinal study among the oldest old living in the center of Japan. Measurements: Habitual dietary intake of MOPUFA was assessed by the brief-type self-administered diet history questionnaire (BDHQ), and functional mobility was assessed by the Timed Up and Go test. Plasma inflammatory biomarkers (C-reactive protein, interleukin-6 and tumor necrosis factor-a) were measured. We evaluated the cross-sectional association between habitual intake of MOPUFA and functional mobility using multivariate logistic regression analysis - Prior to the analysis, validation of BDHQ in this study was confirmed among 190 participants (96 men, 94 women) based on the EPA and DHA concentrations in the erythrocyte membrane phospholipids as reference. Results: Moderate correlation between estimated dietary intake of EPA/DHA and concentration of EPA/DHA in the erythrocyte membrane phospholipids was obtained (Spearman's r=0.29-0.58, p<0.01). Multivariate logistic regression analysis revealed that a lower habitual intake of EPA+DHA was significantly associated with poor functional mobility in men but not in women (OR (95%CI) per 1 SD increase of EPA+DHA intake; 0.55 (0.33-0.91), 0.88 (0.59-1.32), men and women respectively). Conclusions: Habitual intake of MOPUFA was associated with functional mobility in community-dwelling oldest old men.

KW - community-dwelling oldest old

KW - diet history questionnaire

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KW - n-3 polyunsaturated fatty acids

KW - Timed Up and Go test

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