TY - JOUR
T1 - Association of marine-origin N-3 polyunsaturated fatty acids consumption and functional mobility in the community-dwelling oldest old
AU - Takayama, Michiyo
AU - Arai, Y.
AU - Sasaki, S.
AU - Hashimoto, M.
AU - Shimizu, K.
AU - Abe, Y.
AU - Hirose, N.
N1 - Funding Information:
Acknowledgments: This study was supported by Differing Fields Collaboration Grant, the Center for research Promotion’s Grant Programs for researchers, keio university, and the Grant-in-aid for Scientific research (C) (MeXT kakeNHi 20590706, 21590775), with additional funding from Japan Health Foundation for the Prevention of Chronic Disease and improvement of QoL of Patients, Foundation for Total Health Promotion, The univers Foundation, and the Chiyoda Mutual Life Foundation. We are indebted to the participants and their families for the generous donation of their time and personal information.
PY - 2013/1
Y1 - 2013/1
N2 - Objective: To examine whether habitual dietary intake of marine-origin n-3 polyunsaturated fatty acids (MOPUFA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are associated with functional mobility in the community-dwelling oldest old, 85 years or older, who are at high risk for physical disability. Design: A cross-sectional study. Setting: A community-based survey conducted at university research center or home-based. Participants: Four hundred seventeen (189 men, 228 women) out of 542 participants in the baseline examination of the Tokyo Oldest Old Survey on Total Health, a community-based ongoing longitudinal study among the oldest old living in the center of Japan. Measurements: Habitual dietary intake of MOPUFA was assessed by the brief-type self-administered diet history questionnaire (BDHQ), and functional mobility was assessed by the Timed Up and Go test. Plasma inflammatory biomarkers (C-reactive protein, interleukin-6 and tumor necrosis factor-a) were measured. We evaluated the cross-sectional association between habitual intake of MOPUFA and functional mobility using multivariate logistic regression analysis - Prior to the analysis, validation of BDHQ in this study was confirmed among 190 participants (96 men, 94 women) based on the EPA and DHA concentrations in the erythrocyte membrane phospholipids as reference. Results: Moderate correlation between estimated dietary intake of EPA/DHA and concentration of EPA/DHA in the erythrocyte membrane phospholipids was obtained (Spearman's r=0.29-0.58, p<0.01). Multivariate logistic regression analysis revealed that a lower habitual intake of EPA+DHA was significantly associated with poor functional mobility in men but not in women (OR (95%CI) per 1 SD increase of EPA+DHA intake; 0.55 (0.33-0.91), 0.88 (0.59-1.32), men and women respectively). Conclusions: Habitual intake of MOPUFA was associated with functional mobility in community-dwelling oldest old men.
AB - Objective: To examine whether habitual dietary intake of marine-origin n-3 polyunsaturated fatty acids (MOPUFA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are associated with functional mobility in the community-dwelling oldest old, 85 years or older, who are at high risk for physical disability. Design: A cross-sectional study. Setting: A community-based survey conducted at university research center or home-based. Participants: Four hundred seventeen (189 men, 228 women) out of 542 participants in the baseline examination of the Tokyo Oldest Old Survey on Total Health, a community-based ongoing longitudinal study among the oldest old living in the center of Japan. Measurements: Habitual dietary intake of MOPUFA was assessed by the brief-type self-administered diet history questionnaire (BDHQ), and functional mobility was assessed by the Timed Up and Go test. Plasma inflammatory biomarkers (C-reactive protein, interleukin-6 and tumor necrosis factor-a) were measured. We evaluated the cross-sectional association between habitual intake of MOPUFA and functional mobility using multivariate logistic regression analysis - Prior to the analysis, validation of BDHQ in this study was confirmed among 190 participants (96 men, 94 women) based on the EPA and DHA concentrations in the erythrocyte membrane phospholipids as reference. Results: Moderate correlation between estimated dietary intake of EPA/DHA and concentration of EPA/DHA in the erythrocyte membrane phospholipids was obtained (Spearman's r=0.29-0.58, p<0.01). Multivariate logistic regression analysis revealed that a lower habitual intake of EPA+DHA was significantly associated with poor functional mobility in men but not in women (OR (95%CI) per 1 SD increase of EPA+DHA intake; 0.55 (0.33-0.91), 0.88 (0.59-1.32), men and women respectively). Conclusions: Habitual intake of MOPUFA was associated with functional mobility in community-dwelling oldest old men.
KW - Timed Up and Go test
KW - community-dwelling oldest old
KW - diet history questionnaire
KW - functional mobility
KW - n-3 polyunsaturated fatty acids
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U2 - 10.1007/s12603-012-0389-1
DO - 10.1007/s12603-012-0389-1
M3 - Article
C2 - 23299385
AN - SCOPUS:84872496967
SN - 1279-7707
VL - 17
SP - 82
EP - 89
JO - Journal of Nutrition, Health and Aging
JF - Journal of Nutrition, Health and Aging
IS - 1
ER -
