Association of microalbuminuria with brachial-ankle pulse wave velocity: The Ohasama study

Tomofumi Ishikawa, Junichiro Hashimoto, Rieko H. Morito, Tomohiro Hanazawa, Tomoyuki Aikawa, Azusa Hara, Yoriko Shintani, Hirohito Metoki, Ryusuke Inoue, Kei Asayama, Masahiro Kikuya, Takayoshi Ohkubo, Kazuhito Totsune, Haruhisa Hoshi, Hiroshi Satoh, Yutaka Imai

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Background: Microalbuminuria is recognized as a marker of generalized vascular dysfunction. However, the associations between microalbuminuria and pulse wave velocity (PWV), carotid intima-media thickness (IMT), and ambulatory blood pressure (ABP), respectively, have not been investigated. Methods: Brachial-ankle PWV (baPWV), IMT, and ABP were determined in 328 individuals (mean age, 65.7 ± 6.4 years) from the general population of Ohasama, a rural Japanese community. The participants were assigned to groups with microalbuminuria and with normoalbuminuria, and their characteristics were compared. We also examined the association between microalbuminuria and baPWV, IMT, and ABP, respectively, using multivariate analyses. Results: Seventy-nine participants (24%) with microalbuminuria had significantly higher baPWV (P < 0.001) and 24-h systolic BP (SBP) (P = 0.006) than those with normoalbuminuria, although 24-h pulse pressure and mean IMT did not significantly differ between the groups. Multiple logistic regression analyses showed that baPWV, but not 24-h ABP, was independently associated with microalbuminuria (P = 0.002) when adjusted for various confounding factors. After further adjustment for 24-h SBP, the association between baPWV and microalbuminuria remained significant (P = 0.012). The trend was significant even when daytime or nighttime SBP was used instead of 24-hour SBP in this model. Conclusions: Microalbuminuria appears to be associated with baPWV more closely than with IMT and ABP, and its association with baPWV is independent of ABP and other cardiovascular risk factors.

Original languageEnglish
Pages (from-to)413-418
Number of pages6
JournalAmerican journal of hypertension
Volume21
Issue number4
DOIs
Publication statusPublished - 2008 Apr 1
Externally publishedYes

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Pulse Wave Analysis
Ankle
Arm
Blood Pressure
Carotid Intima-Media Thickness
Rural Population
Blood Vessels
Multivariate Analysis
Logistic Models
Regression Analysis
Population

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Association of microalbuminuria with brachial-ankle pulse wave velocity : The Ohasama study. / Ishikawa, Tomofumi; Hashimoto, Junichiro; Morito, Rieko H.; Hanazawa, Tomohiro; Aikawa, Tomoyuki; Hara, Azusa; Shintani, Yoriko; Metoki, Hirohito; Inoue, Ryusuke; Asayama, Kei; Kikuya, Masahiro; Ohkubo, Takayoshi; Totsune, Kazuhito; Hoshi, Haruhisa; Satoh, Hiroshi; Imai, Yutaka.

In: American journal of hypertension, Vol. 21, No. 4, 01.04.2008, p. 413-418.

Research output: Contribution to journalArticle

Ishikawa, T, Hashimoto, J, Morito, RH, Hanazawa, T, Aikawa, T, Hara, A, Shintani, Y, Metoki, H, Inoue, R, Asayama, K, Kikuya, M, Ohkubo, T, Totsune, K, Hoshi, H, Satoh, H & Imai, Y 2008, 'Association of microalbuminuria with brachial-ankle pulse wave velocity: The Ohasama study', American journal of hypertension, vol. 21, no. 4, pp. 413-418. https://doi.org/10.1038/ajh.2007.77
Ishikawa, Tomofumi ; Hashimoto, Junichiro ; Morito, Rieko H. ; Hanazawa, Tomohiro ; Aikawa, Tomoyuki ; Hara, Azusa ; Shintani, Yoriko ; Metoki, Hirohito ; Inoue, Ryusuke ; Asayama, Kei ; Kikuya, Masahiro ; Ohkubo, Takayoshi ; Totsune, Kazuhito ; Hoshi, Haruhisa ; Satoh, Hiroshi ; Imai, Yutaka. / Association of microalbuminuria with brachial-ankle pulse wave velocity : The Ohasama study. In: American journal of hypertension. 2008 ; Vol. 21, No. 4. pp. 413-418.
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author = "Tomofumi Ishikawa and Junichiro Hashimoto and Morito, {Rieko H.} and Tomohiro Hanazawa and Tomoyuki Aikawa and Azusa Hara and Yoriko Shintani and Hirohito Metoki and Ryusuke Inoue and Kei Asayama and Masahiro Kikuya and Takayoshi Ohkubo and Kazuhito Totsune and Haruhisa Hoshi and Hiroshi Satoh and Yutaka Imai",
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T1 - Association of microalbuminuria with brachial-ankle pulse wave velocity

T2 - The Ohasama study

AU - Ishikawa, Tomofumi

AU - Hashimoto, Junichiro

AU - Morito, Rieko H.

AU - Hanazawa, Tomohiro

AU - Aikawa, Tomoyuki

AU - Hara, Azusa

AU - Shintani, Yoriko

AU - Metoki, Hirohito

AU - Inoue, Ryusuke

AU - Asayama, Kei

AU - Kikuya, Masahiro

AU - Ohkubo, Takayoshi

AU - Totsune, Kazuhito

AU - Hoshi, Haruhisa

AU - Satoh, Hiroshi

AU - Imai, Yutaka

PY - 2008/4/1

Y1 - 2008/4/1

N2 - Background: Microalbuminuria is recognized as a marker of generalized vascular dysfunction. However, the associations between microalbuminuria and pulse wave velocity (PWV), carotid intima-media thickness (IMT), and ambulatory blood pressure (ABP), respectively, have not been investigated. Methods: Brachial-ankle PWV (baPWV), IMT, and ABP were determined in 328 individuals (mean age, 65.7 ± 6.4 years) from the general population of Ohasama, a rural Japanese community. The participants were assigned to groups with microalbuminuria and with normoalbuminuria, and their characteristics were compared. We also examined the association between microalbuminuria and baPWV, IMT, and ABP, respectively, using multivariate analyses. Results: Seventy-nine participants (24%) with microalbuminuria had significantly higher baPWV (P < 0.001) and 24-h systolic BP (SBP) (P = 0.006) than those with normoalbuminuria, although 24-h pulse pressure and mean IMT did not significantly differ between the groups. Multiple logistic regression analyses showed that baPWV, but not 24-h ABP, was independently associated with microalbuminuria (P = 0.002) when adjusted for various confounding factors. After further adjustment for 24-h SBP, the association between baPWV and microalbuminuria remained significant (P = 0.012). The trend was significant even when daytime or nighttime SBP was used instead of 24-hour SBP in this model. Conclusions: Microalbuminuria appears to be associated with baPWV more closely than with IMT and ABP, and its association with baPWV is independent of ABP and other cardiovascular risk factors.

AB - Background: Microalbuminuria is recognized as a marker of generalized vascular dysfunction. However, the associations between microalbuminuria and pulse wave velocity (PWV), carotid intima-media thickness (IMT), and ambulatory blood pressure (ABP), respectively, have not been investigated. Methods: Brachial-ankle PWV (baPWV), IMT, and ABP were determined in 328 individuals (mean age, 65.7 ± 6.4 years) from the general population of Ohasama, a rural Japanese community. The participants were assigned to groups with microalbuminuria and with normoalbuminuria, and their characteristics were compared. We also examined the association between microalbuminuria and baPWV, IMT, and ABP, respectively, using multivariate analyses. Results: Seventy-nine participants (24%) with microalbuminuria had significantly higher baPWV (P < 0.001) and 24-h systolic BP (SBP) (P = 0.006) than those with normoalbuminuria, although 24-h pulse pressure and mean IMT did not significantly differ between the groups. Multiple logistic regression analyses showed that baPWV, but not 24-h ABP, was independently associated with microalbuminuria (P = 0.002) when adjusted for various confounding factors. After further adjustment for 24-h SBP, the association between baPWV and microalbuminuria remained significant (P = 0.012). The trend was significant even when daytime or nighttime SBP was used instead of 24-hour SBP in this model. Conclusions: Microalbuminuria appears to be associated with baPWV more closely than with IMT and ABP, and its association with baPWV is independent of ABP and other cardiovascular risk factors.

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