Association of (pro)renin receptor gene polymorphisms with lacunar infarction and left ventricular hypertrophy in Japanese women: The Ohasama study

Takuo Hirose, Masahiro Hashimoto, Kazuhito Totsune, Hirohito Metoki, Azusa Hara, Michihiro Satoh, Masahiro Kikuya, Takayoshi Ohkubo, Kei Asayama, Takeo Kondo, Kei Kamide, Tomohiro Katsuya, Toshio Ogihara, Shin Ichi Izumi, Hiromi Rakugi, Kazuhiro Takahashi, Yutaka Imai

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Recent studies have revealed that (pro)renin receptor ((P)RR), a newly identified member of the renin-angiotensin system, is associated with organ damage that occurs with cardiovascular disease. We investigated the association of genetic polymorphisms in the (P)RR gene with lacunar infarction, white matter hyperintensity and left ventricular hypertrophy (LVH) in a Japanese general population recruited from the Ohasama study, a Japanese cohort study. A total of 779 subjects (men250 and women529) were recruited. For the association study, we selected three polymorphisms: 782AG (rs2968915), intervening sequence (IVS)5169CT (rs5918007) and 1513AG (rs6609080). In women, the prevalence of lacunar infarction and LVH was significantly higher in subjects with the 1513GG genotype than in those with the AA or AG genotypes (lacunar infarction: P0.01, LVH: P0.003). Plasma renin activity (PRA) levels in women with the GG genotype were significantly lower than in women with the AA or AG genotypes (P0.01). Multiple logistic regression analysis adjusted for confounding factors demonstrated that 1513AG polymorphism was significantly and independently associated with the risk of lacunar infarction (trend P0.03) and LVH (trend P0.003). In men, there were no significant differences in lacunar infarction, LVH or PRA levels among the three genotypes. The polymorphism of the (P)RR gene 1513AG is associated with lacunar infarction and LVH in Japanese women. These results suggest that (P)RR has a role in organ damage in humans.

Original languageEnglish
Pages (from-to)530-535
Number of pages6
JournalHypertension Research
Volume34
Issue number4
DOIs
Publication statusPublished - 2011 Apr 1
Externally publishedYes

Fingerprint

Lacunar Stroke
Left Ventricular Hypertrophy
Renin
Genotype
Genes
Genetic Polymorphisms
Renin-Angiotensin System
Introns
Cohort Studies
Cardiovascular Diseases
Logistic Models
Regression Analysis
Population

Keywords

  • (pro)renin receptor
  • organ damage
  • polymorphism
  • renin-angiotensin system

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Association of (pro)renin receptor gene polymorphisms with lacunar infarction and left ventricular hypertrophy in Japanese women : The Ohasama study. / Hirose, Takuo; Hashimoto, Masahiro; Totsune, Kazuhito; Metoki, Hirohito; Hara, Azusa; Satoh, Michihiro; Kikuya, Masahiro; Ohkubo, Takayoshi; Asayama, Kei; Kondo, Takeo; Kamide, Kei; Katsuya, Tomohiro; Ogihara, Toshio; Izumi, Shin Ichi; Rakugi, Hiromi; Takahashi, Kazuhiro; Imai, Yutaka.

In: Hypertension Research, Vol. 34, No. 4, 01.04.2011, p. 530-535.

Research output: Contribution to journalArticle

Hirose, T, Hashimoto, M, Totsune, K, Metoki, H, Hara, A, Satoh, M, Kikuya, M, Ohkubo, T, Asayama, K, Kondo, T, Kamide, K, Katsuya, T, Ogihara, T, Izumi, SI, Rakugi, H, Takahashi, K & Imai, Y 2011, 'Association of (pro)renin receptor gene polymorphisms with lacunar infarction and left ventricular hypertrophy in Japanese women: The Ohasama study', Hypertension Research, vol. 34, no. 4, pp. 530-535. https://doi.org/10.1038/hr.2010.274
Hirose, Takuo ; Hashimoto, Masahiro ; Totsune, Kazuhito ; Metoki, Hirohito ; Hara, Azusa ; Satoh, Michihiro ; Kikuya, Masahiro ; Ohkubo, Takayoshi ; Asayama, Kei ; Kondo, Takeo ; Kamide, Kei ; Katsuya, Tomohiro ; Ogihara, Toshio ; Izumi, Shin Ichi ; Rakugi, Hiromi ; Takahashi, Kazuhiro ; Imai, Yutaka. / Association of (pro)renin receptor gene polymorphisms with lacunar infarction and left ventricular hypertrophy in Japanese women : The Ohasama study. In: Hypertension Research. 2011 ; Vol. 34, No. 4. pp. 530-535.
@article{95f20aa5afc240478989264821f4d841,
title = "Association of (pro)renin receptor gene polymorphisms with lacunar infarction and left ventricular hypertrophy in Japanese women: The Ohasama study",
abstract = "Recent studies have revealed that (pro)renin receptor ((P)RR), a newly identified member of the renin-angiotensin system, is associated with organ damage that occurs with cardiovascular disease. We investigated the association of genetic polymorphisms in the (P)RR gene with lacunar infarction, white matter hyperintensity and left ventricular hypertrophy (LVH) in a Japanese general population recruited from the Ohasama study, a Japanese cohort study. A total of 779 subjects (men250 and women529) were recruited. For the association study, we selected three polymorphisms: 782AG (rs2968915), intervening sequence (IVS)5169CT (rs5918007) and 1513AG (rs6609080). In women, the prevalence of lacunar infarction and LVH was significantly higher in subjects with the 1513GG genotype than in those with the AA or AG genotypes (lacunar infarction: P0.01, LVH: P0.003). Plasma renin activity (PRA) levels in women with the GG genotype were significantly lower than in women with the AA or AG genotypes (P0.01). Multiple logistic regression analysis adjusted for confounding factors demonstrated that 1513AG polymorphism was significantly and independently associated with the risk of lacunar infarction (trend P0.03) and LVH (trend P0.003). In men, there were no significant differences in lacunar infarction, LVH or PRA levels among the three genotypes. The polymorphism of the (P)RR gene 1513AG is associated with lacunar infarction and LVH in Japanese women. These results suggest that (P)RR has a role in organ damage in humans.",
keywords = "(pro)renin receptor, organ damage, polymorphism, renin-angiotensin system",
author = "Takuo Hirose and Masahiro Hashimoto and Kazuhito Totsune and Hirohito Metoki and Azusa Hara and Michihiro Satoh and Masahiro Kikuya and Takayoshi Ohkubo and Kei Asayama and Takeo Kondo and Kei Kamide and Tomohiro Katsuya and Toshio Ogihara and Izumi, {Shin Ichi} and Hiromi Rakugi and Kazuhiro Takahashi and Yutaka Imai",
year = "2011",
month = "4",
day = "1",
doi = "10.1038/hr.2010.274",
language = "English",
volume = "34",
pages = "530--535",
journal = "Hypertension Research",
issn = "0916-9636",
publisher = "Nature Publishing Group",
number = "4",

}

TY - JOUR

T1 - Association of (pro)renin receptor gene polymorphisms with lacunar infarction and left ventricular hypertrophy in Japanese women

T2 - The Ohasama study

AU - Hirose, Takuo

AU - Hashimoto, Masahiro

AU - Totsune, Kazuhito

AU - Metoki, Hirohito

AU - Hara, Azusa

AU - Satoh, Michihiro

AU - Kikuya, Masahiro

AU - Ohkubo, Takayoshi

AU - Asayama, Kei

AU - Kondo, Takeo

AU - Kamide, Kei

AU - Katsuya, Tomohiro

AU - Ogihara, Toshio

AU - Izumi, Shin Ichi

AU - Rakugi, Hiromi

AU - Takahashi, Kazuhiro

AU - Imai, Yutaka

PY - 2011/4/1

Y1 - 2011/4/1

N2 - Recent studies have revealed that (pro)renin receptor ((P)RR), a newly identified member of the renin-angiotensin system, is associated with organ damage that occurs with cardiovascular disease. We investigated the association of genetic polymorphisms in the (P)RR gene with lacunar infarction, white matter hyperintensity and left ventricular hypertrophy (LVH) in a Japanese general population recruited from the Ohasama study, a Japanese cohort study. A total of 779 subjects (men250 and women529) were recruited. For the association study, we selected three polymorphisms: 782AG (rs2968915), intervening sequence (IVS)5169CT (rs5918007) and 1513AG (rs6609080). In women, the prevalence of lacunar infarction and LVH was significantly higher in subjects with the 1513GG genotype than in those with the AA or AG genotypes (lacunar infarction: P0.01, LVH: P0.003). Plasma renin activity (PRA) levels in women with the GG genotype were significantly lower than in women with the AA or AG genotypes (P0.01). Multiple logistic regression analysis adjusted for confounding factors demonstrated that 1513AG polymorphism was significantly and independently associated with the risk of lacunar infarction (trend P0.03) and LVH (trend P0.003). In men, there were no significant differences in lacunar infarction, LVH or PRA levels among the three genotypes. The polymorphism of the (P)RR gene 1513AG is associated with lacunar infarction and LVH in Japanese women. These results suggest that (P)RR has a role in organ damage in humans.

AB - Recent studies have revealed that (pro)renin receptor ((P)RR), a newly identified member of the renin-angiotensin system, is associated with organ damage that occurs with cardiovascular disease. We investigated the association of genetic polymorphisms in the (P)RR gene with lacunar infarction, white matter hyperintensity and left ventricular hypertrophy (LVH) in a Japanese general population recruited from the Ohasama study, a Japanese cohort study. A total of 779 subjects (men250 and women529) were recruited. For the association study, we selected three polymorphisms: 782AG (rs2968915), intervening sequence (IVS)5169CT (rs5918007) and 1513AG (rs6609080). In women, the prevalence of lacunar infarction and LVH was significantly higher in subjects with the 1513GG genotype than in those with the AA or AG genotypes (lacunar infarction: P0.01, LVH: P0.003). Plasma renin activity (PRA) levels in women with the GG genotype were significantly lower than in women with the AA or AG genotypes (P0.01). Multiple logistic regression analysis adjusted for confounding factors demonstrated that 1513AG polymorphism was significantly and independently associated with the risk of lacunar infarction (trend P0.03) and LVH (trend P0.003). In men, there were no significant differences in lacunar infarction, LVH or PRA levels among the three genotypes. The polymorphism of the (P)RR gene 1513AG is associated with lacunar infarction and LVH in Japanese women. These results suggest that (P)RR has a role in organ damage in humans.

KW - (pro)renin receptor

KW - organ damage

KW - polymorphism

KW - renin-angiotensin system

UR - http://www.scopus.com/inward/record.url?scp=79953704792&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79953704792&partnerID=8YFLogxK

U2 - 10.1038/hr.2010.274

DO - 10.1038/hr.2010.274

M3 - Article

C2 - 21228785

AN - SCOPUS:79953704792

VL - 34

SP - 530

EP - 535

JO - Hypertension Research

JF - Hypertension Research

SN - 0916-9636

IS - 4

ER -