Abstract
Background/Aims: A significant role of (pro)renin receptor in the pathogenesis of end-organ damage has been suggested only in animal studies. This study was conducted to examine the mRNA expression of (pro)renin receptor in human artery. Methods: In 141 kidney failure patients, the mRNA was harvested from arterial fragments obtained during surgery constructing an arteriovenous access for hemodialysis therapy, and expression levels of (pro)renin receptor and other components of the renin-angiotensin system were determined. Results: Arterial (pro)renin receptor expression was similar in diabetic and non-diabetic patients, although plasma prorenin levels were significantly higher in the diabetic patients than in the non-diabetic patients. The arterial (pro)renin receptor mRNA levels of the hypertensive patients, who had not been treated with either angiotensin-converting enzyme (ACE) inhibitors or angiotensin II type 1 receptor blockers, were significantly lower than those of the patients who had been treated with either drug. Multiple regression analyses showed a significant association with a large coefficient between the arterial mRNA level of the (pro)renin receptor and the arterial mRNA level of ACE; this significant association disappeared in patients who had been treated with either drug. Conclusion: (Pro)renin receptor may contribute to the generation of arterial angiotensin II in kidney failure patients.
| Original language | English |
|---|---|
| Pages (from-to) | 361-370 |
| Number of pages | 10 |
| Journal | American Journal of Nephrology |
| Volume | 30 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2009 Oct |
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Keywords
- Angiotensin-converting enzyme
- Angiotensinogen
- Diabetes
- Neprilysin
- Prorenin
ASJC Scopus subject areas
- Nephrology
Cite this
Association of (Pro)renin receptor mRNA expression with angiotensin-converting enzyme mRNA expression in human artery. / Takemitsu, Tomoko; Ichihara, Atsuhiro; Kaneshiro, Yuki; Sakoda, Mariyo; Kurauchi-Mito, Asako; Narita, Tatsuya; Kinouchi, Kenichiro; Yamashita, Norimasa; Itoh, Hiroshi.
In: American Journal of Nephrology, Vol. 30, No. 4, 10.2009, p. 361-370.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association of (Pro)renin receptor mRNA expression with angiotensin-converting enzyme mRNA expression in human artery
AU - Takemitsu, Tomoko
AU - Ichihara, Atsuhiro
AU - Kaneshiro, Yuki
AU - Sakoda, Mariyo
AU - Kurauchi-Mito, Asako
AU - Narita, Tatsuya
AU - Kinouchi, Kenichiro
AU - Yamashita, Norimasa
AU - Itoh, Hiroshi
PY - 2009/10
Y1 - 2009/10
N2 - Background/Aims: A significant role of (pro)renin receptor in the pathogenesis of end-organ damage has been suggested only in animal studies. This study was conducted to examine the mRNA expression of (pro)renin receptor in human artery. Methods: In 141 kidney failure patients, the mRNA was harvested from arterial fragments obtained during surgery constructing an arteriovenous access for hemodialysis therapy, and expression levels of (pro)renin receptor and other components of the renin-angiotensin system were determined. Results: Arterial (pro)renin receptor expression was similar in diabetic and non-diabetic patients, although plasma prorenin levels were significantly higher in the diabetic patients than in the non-diabetic patients. The arterial (pro)renin receptor mRNA levels of the hypertensive patients, who had not been treated with either angiotensin-converting enzyme (ACE) inhibitors or angiotensin II type 1 receptor blockers, were significantly lower than those of the patients who had been treated with either drug. Multiple regression analyses showed a significant association with a large coefficient between the arterial mRNA level of the (pro)renin receptor and the arterial mRNA level of ACE; this significant association disappeared in patients who had been treated with either drug. Conclusion: (Pro)renin receptor may contribute to the generation of arterial angiotensin II in kidney failure patients.
AB - Background/Aims: A significant role of (pro)renin receptor in the pathogenesis of end-organ damage has been suggested only in animal studies. This study was conducted to examine the mRNA expression of (pro)renin receptor in human artery. Methods: In 141 kidney failure patients, the mRNA was harvested from arterial fragments obtained during surgery constructing an arteriovenous access for hemodialysis therapy, and expression levels of (pro)renin receptor and other components of the renin-angiotensin system were determined. Results: Arterial (pro)renin receptor expression was similar in diabetic and non-diabetic patients, although plasma prorenin levels were significantly higher in the diabetic patients than in the non-diabetic patients. The arterial (pro)renin receptor mRNA levels of the hypertensive patients, who had not been treated with either angiotensin-converting enzyme (ACE) inhibitors or angiotensin II type 1 receptor blockers, were significantly lower than those of the patients who had been treated with either drug. Multiple regression analyses showed a significant association with a large coefficient between the arterial mRNA level of the (pro)renin receptor and the arterial mRNA level of ACE; this significant association disappeared in patients who had been treated with either drug. Conclusion: (Pro)renin receptor may contribute to the generation of arterial angiotensin II in kidney failure patients.
KW - Angiotensin-converting enzyme
KW - Angiotensinogen
KW - Diabetes
KW - Neprilysin
KW - Prorenin
UR - http://www.scopus.com/inward/record.url?scp=67651230076&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67651230076&partnerID=8YFLogxK
U2 - 10.1159/000232199
DO - 10.1159/000232199
M3 - Article
C2 - 19641301
AN - SCOPUS:67651230076
VL - 30
SP - 361
EP - 370
JO - American Journal of Nephrology
JF - American Journal of Nephrology
SN - 0250-8095
IS - 4
ER -