Association of ras p21 with differentiation of epidermal keratinocytes in proliferating skin diseases

Arata Kikuchi, Masayuki Amagai, Takeji Nishikawa

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We examined the localization of DNA replicating cells and ras oncogene product p21 positive cells in proliferating skin diseases, such as psoriasis vulgaris, lichen planus, verruca vulgaris, verruca plana juvenilis and seborrheic keratosis. ras p21-positive cells were found rather in the differentiated layers than in the proliferating layers of the epidermis. We indicate that the expression of ras p21 can be associated with the differentiation of epidermal keratinocytes not only in tumor tissues but also in inflammatory skin diseases.

Original languageEnglish
Pages (from-to)83-86
Number of pages4
JournalJournal of Dermatological Science
Volume4
Issue number2
DOIs
Publication statusPublished - 1992

Fingerprint

Proto-Oncogene Proteins p21(ras)
Keratinocytes
Skin Diseases
Oncogene Protein p21(ras)
Skin
Warts
Cells
Temazepam
Seborrheic Keratosis
Tumors
Lichen Planus
Tissue
Psoriasis
Epidermis
DNA
Neoplasms
Lichens

Keywords

  • Differentiation
  • DNA replicating cell
  • Proliferating skin disease
  • ras p21

ASJC Scopus subject areas

  • Dermatology

Cite this

Association of ras p21 with differentiation of epidermal keratinocytes in proliferating skin diseases. / Kikuchi, Arata; Amagai, Masayuki; Nishikawa, Takeji.

In: Journal of Dermatological Science, Vol. 4, No. 2, 1992, p. 83-86.

Research output: Contribution to journalArticle

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