Association of the human lymphocyte-DR2 antigen with Japanese ulcerative colitis

H. Asakura, M. Tsuchiya, S. Aiso, M. Watanabe, K. Kobayashi, T. Hibi, K. Ando, H. Takata, S. Sekiguchi

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Abstract

The frequency deviation of human lymphocyte-DR antigens as well as human lyphocyte A, B, and C antigens was assessed in 40 Japanese patients with ulcerative colitis and compared with 51 ethnically matched healthy Japanese. The antigen that was of significantly higher frequency in patients with ulcerative colitis was HLA-DR2. This antigen was found in 70% of the patients vs. 31% of controls (χ2 = 13.4, p < 0.001, corrected p < 0.01, relative risk = 5.1). In addition, an increased frequency of HLA-B5-DR2, which is the most common haplotype in Japanese populations, was found in 55% of the patients with ulcerative colitis compared with 22% of the controls (χ2 = 10.84, p < 0.001).

Original languageEnglish
Pages (from-to)413-418
Number of pages6
JournalGastroenterology
Volume82
Issue number3
Publication statusPublished - 1982

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Ulcerative Colitis
HLA-DR2 Antigen
Lymphocytes
Antigens
Haplotypes
Population

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Asakura, H., Tsuchiya, M., Aiso, S., Watanabe, M., Kobayashi, K., Hibi, T., ... Sekiguchi, S. (1982). Association of the human lymphocyte-DR2 antigen with Japanese ulcerative colitis. Gastroenterology, 82(3), 413-418.

Association of the human lymphocyte-DR2 antigen with Japanese ulcerative colitis. / Asakura, H.; Tsuchiya, M.; Aiso, S.; Watanabe, M.; Kobayashi, K.; Hibi, T.; Ando, K.; Takata, H.; Sekiguchi, S.

In: Gastroenterology, Vol. 82, No. 3, 1982, p. 413-418.

Research output: Contribution to journalArticle

Asakura, H, Tsuchiya, M, Aiso, S, Watanabe, M, Kobayashi, K, Hibi, T, Ando, K, Takata, H & Sekiguchi, S 1982, 'Association of the human lymphocyte-DR2 antigen with Japanese ulcerative colitis', Gastroenterology, vol. 82, no. 3, pp. 413-418.
Asakura H, Tsuchiya M, Aiso S, Watanabe M, Kobayashi K, Hibi T et al. Association of the human lymphocyte-DR2 antigen with Japanese ulcerative colitis. Gastroenterology. 1982;82(3):413-418.
Asakura, H. ; Tsuchiya, M. ; Aiso, S. ; Watanabe, M. ; Kobayashi, K. ; Hibi, T. ; Ando, K. ; Takata, H. ; Sekiguchi, S. / Association of the human lymphocyte-DR2 antigen with Japanese ulcerative colitis. In: Gastroenterology. 1982 ; Vol. 82, No. 3. pp. 413-418.
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AU - Hibi, T.

AU - Ando, K.

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