Association of the Human Lymphocyte-DR2 Antigen with Japanese Ulcerative Colitis

Hitoshi Asakura, Masaharu Tsuchiya, Sadakazu Aiso, Mamoru Watanabe, Kensuke Kobayashi, Toshifumi Hibi, Koshi Ando, Hajime Takata, Susumu Sekiguchi

Research output: Contribution to journalArticle

141 Citations (Scopus)

Abstract

The frequency deviation of human lymphocyte-DR antigens as well as human lymphocyte A, B, and C antigens was assessed in 40 Japanese patients with ulcerative colitis and compared with 51 ethnically matched healthy Japanese. The antigen that was o f significantly higher frequency in patients with ulcerative colitis was HLA-DR2. This antigen was found in 70% o f the patients vs. 31% of controls (χ2 = 13.4, p < 0.001, corrected p < 0.01, relative risk = 5.1). In addition, an increased frequency o f HLA-B5-DR2, which is the most common haplotype in Japanese populations, was found in 55% of the patients with ulcerative colitis compared with 22% of the controls (χ2 = 10.84, p < 0.001).

Original languageEnglish
Pages (from-to)413-418
Number of pages6
JournalGastroenterology
Volume82
Issue number3
DOIs
Publication statusPublished - 1982 Jan 1

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Fingerprint Dive into the research topics of 'Association of the Human Lymphocyte-DR2 Antigen with Japanese Ulcerative Colitis'. Together they form a unique fingerprint.

  • Cite this

    Asakura, H., Tsuchiya, M., Aiso, S., Watanabe, M., Kobayashi, K., Hibi, T., Ando, K., Takata, H., & Sekiguchi, S. (1982). Association of the Human Lymphocyte-DR2 Antigen with Japanese Ulcerative Colitis. Gastroenterology, 82(3), 413-418. https://doi.org/10.1016/S0016-5085(82)80387-9