Association of the XBP1 -116C/G polymorphism with schizophrenia in the Japanese population

Chihiro Kakiuchi; Mizuho Ishiwata; Tadashi Umekage; Mamoru Tochigi; Kazuhisa Kohda; Tsukasa Sasaki; Tadafumi Kato

doi:10.1111/j.1440-1819.2004.01280.x

Association of the XBP1 -116C/G polymorphism with schizophrenia in the Japanese population

Chihiro Kakiuchi, Mizuho Ishiwata, Tadashi Umekage, Mamoru Tochigi, Kazuhisa Kohda, Tsukasa Sasaki, Tadafumi Kato

Department of Physiology

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Abstract

Schizophrenia and bipolar disorder share some clinical features and linkage studies have shown that several loci are common. Recently, the authors found that the -116C→C substitution in the promotor region of XBP1, a pivotal gene in endoplasmic reticulum (ER) stress response, causes the impairment of ER stress response, and that the -116C/C genotype is a protective factor; in other words the presence of the G allele increases the risk for bipolar disorder. The gene is located on 22q12.1, which is also linked with schizophrenia. The polymorphisms were investigated in 234 schizophrenic patients as compared with controls. Significant difference of genotype distribution was observed, which suggested that the -116C/C genotype is a protective factor for both of the major mental disorders.

Original language	English
Pages (from-to)	438-440
Number of pages	3
Journal	Psychiatry and Clinical Neurosciences
Volume	58
Issue number	4
DOIs	https://doi.org/10.1111/j.1440-1819.2004.01280.x
Publication status	Published - 2004 Aug

Keywords

Association study
Rheumatoid arthritis
Schizophrenia
XBP1

ASJC Scopus subject areas

Neuroscience(all)
Neurology
Clinical Neurology
Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1440-1819.2004.01280.x

Cite this

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abstract = "Schizophrenia and bipolar disorder share some clinical features and linkage studies have shown that several loci are common. Recently, the authors found that the -116C→C substitution in the promotor region of XBP1, a pivotal gene in endoplasmic reticulum (ER) stress response, causes the impairment of ER stress response, and that the -116C/C genotype is a protective factor; in other words the presence of the G allele increases the risk for bipolar disorder. The gene is located on 22q12.1, which is also linked with schizophrenia. The polymorphisms were investigated in 234 schizophrenic patients as compared with controls. Significant difference of genotype distribution was observed, which suggested that the -116C/C genotype is a protective factor for both of the major mental disorders.",

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AU - Kakiuchi, Chihiro

AU - Ishiwata, Mizuho

AU - Umekage, Tadashi

AU - Tochigi, Mamoru

AU - Kohda, Kazuhisa

AU - Sasaki, Tsukasa

AU - Kato, Tadafumi

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AB - Schizophrenia and bipolar disorder share some clinical features and linkage studies have shown that several loci are common. Recently, the authors found that the -116C→C substitution in the promotor region of XBP1, a pivotal gene in endoplasmic reticulum (ER) stress response, causes the impairment of ER stress response, and that the -116C/C genotype is a protective factor; in other words the presence of the G allele increases the risk for bipolar disorder. The gene is located on 22q12.1, which is also linked with schizophrenia. The polymorphisms were investigated in 234 schizophrenic patients as compared with controls. Significant difference of genotype distribution was observed, which suggested that the -116C/C genotype is a protective factor for both of the major mental disorders.

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Association of the XBP1 -116C/G polymorphism with schizophrenia in the Japanese population

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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