Association of total marine fatty acids, eicosapentaenoic and docosahexaenoic acids, with aortic stiffness in Koreans, whites, and Japanese Americans

ERA JUMP Study Group

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

BACKGROUND: Few previous studies have reported the association of aortic stiffness with marine n-3 fatty acids (Fas) in the general population. The aim of this study was to determine the combined and independent associations of 2 major marine n-3 FAs, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), with aortic stiffness evaluated using carotid-femoral pulse wave velocity (cfPWV) in Korean, white, and Japanese American men.

METHODS: A population-based sample of 851 middle-aged men (299 Koreans, 266 whites, and 286 Japanese Americans) was examined for cfPWV during 2002-2006. Serum FAs, including EPA and DHA, were measured as a percentage of total FAs using gas chromatography. Multiple regression analysis was used to examine the association of EPA and DHA with cfPWV after adjusting for blood pressure and other confounders.

RESULTS: Mean EPA and DHA levels were 1.9 (SD = 1.0) and 4.8 (SD = 1.4) for Koreans, 0.8 (SD = 0.6) and 2.4 (SD = 1.2) for whites, and 1.0 (SD = 1.0) and 3.2 (SD = 1.4) for Japanese Americans. Both EPA and DHA were significantly higher in Koreans than in the other 2 groups (P <0.01). Multiple regression analyses in Koreans showed that cfPWV had a significant inverse association with total marine n-3 FAs and with EPA alone after adjusting for blood pressure and other potential confounders. In contrast, there was no significant association of cfPWV with DHA. Whites and Japanese Americans did not show any significant associations of cfPWV with total marine n-3 FAs, EPA, or DHA.

CONCLUSIONS: High levels of EPA observed in Koreans have an inverse association with aortic stiffness.

Original languageEnglish
Pages (from-to)1321-1327
Number of pages7
JournalAmerican Journal of Hypertension
Volume26
Issue number11
DOIs
Publication statusPublished - 2013 Nov 1
Externally publishedYes

Fingerprint

Vascular Stiffness
Eicosapentaenoic Acid
Asian Americans
Docosahexaenoic Acids
Pulse Wave Analysis
Fatty Acids
Thigh
Regression Analysis
Blood Pressure
Omega-3 Fatty Acids
Gas Chromatography
Population
Serum

Keywords

  • aortic stiffness
  • blood pressure
  • carotid femoral pulse wave velocity
  • docosahexaenoic acid
  • eicosapentaenoic acid
  • fish oil
  • hypertension.

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Association of total marine fatty acids, eicosapentaenoic and docosahexaenoic acids, with aortic stiffness in Koreans, whites, and Japanese Americans. / ERA JUMP Study Group.

In: American Journal of Hypertension, Vol. 26, No. 11, 01.11.2013, p. 1321-1327.

Research output: Contribution to journalArticle

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title = "Association of total marine fatty acids, eicosapentaenoic and docosahexaenoic acids, with aortic stiffness in Koreans, whites, and Japanese Americans",
abstract = "BACKGROUND: Few previous studies have reported the association of aortic stiffness with marine n-3 fatty acids (Fas) in the general population. The aim of this study was to determine the combined and independent associations of 2 major marine n-3 FAs, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), with aortic stiffness evaluated using carotid-femoral pulse wave velocity (cfPWV) in Korean, white, and Japanese American men.METHODS: A population-based sample of 851 middle-aged men (299 Koreans, 266 whites, and 286 Japanese Americans) was examined for cfPWV during 2002-2006. Serum FAs, including EPA and DHA, were measured as a percentage of total FAs using gas chromatography. Multiple regression analysis was used to examine the association of EPA and DHA with cfPWV after adjusting for blood pressure and other confounders.RESULTS: Mean EPA and DHA levels were 1.9 (SD = 1.0) and 4.8 (SD = 1.4) for Koreans, 0.8 (SD = 0.6) and 2.4 (SD = 1.2) for whites, and 1.0 (SD = 1.0) and 3.2 (SD = 1.4) for Japanese Americans. Both EPA and DHA were significantly higher in Koreans than in the other 2 groups (P <0.01). Multiple regression analyses in Koreans showed that cfPWV had a significant inverse association with total marine n-3 FAs and with EPA alone after adjusting for blood pressure and other potential confounders. In contrast, there was no significant association of cfPWV with DHA. Whites and Japanese Americans did not show any significant associations of cfPWV with total marine n-3 FAs, EPA, or DHA.CONCLUSIONS: High levels of EPA observed in Koreans have an inverse association with aortic stiffness.",
keywords = "aortic stiffness, blood pressure, carotid femoral pulse wave velocity, docosahexaenoic acid, eicosapentaenoic acid, fish oil, hypertension.",
author = "{ERA JUMP Study Group} and Akira Sekikawa and Chol Shin and Masaki, {Kamal H.} and Barinas-Mitchell, {Emma J M} and Nobutaka Hirooka and Willcox, {Bradley J.} and Jina Choo and Jessica White and Evans, {Rhobert W.} and Akira Fujiyoshi and Tomonori Okamura and Katsuyuki Miura and Muldoon, {Matthew F.} and Hirotsugu Ueshima and Kuller, {Lewis H.} and Kim Sutton-Tyrrell",
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TY - JOUR

T1 - Association of total marine fatty acids, eicosapentaenoic and docosahexaenoic acids, with aortic stiffness in Koreans, whites, and Japanese Americans

AU - ERA JUMP Study Group

AU - Sekikawa, Akira

AU - Shin, Chol

AU - Masaki, Kamal H.

AU - Barinas-Mitchell, Emma J M

AU - Hirooka, Nobutaka

AU - Willcox, Bradley J.

AU - Choo, Jina

AU - White, Jessica

AU - Evans, Rhobert W.

AU - Fujiyoshi, Akira

AU - Okamura, Tomonori

AU - Miura, Katsuyuki

AU - Muldoon, Matthew F.

AU - Ueshima, Hirotsugu

AU - Kuller, Lewis H.

AU - Sutton-Tyrrell, Kim

PY - 2013/11/1

Y1 - 2013/11/1

N2 - BACKGROUND: Few previous studies have reported the association of aortic stiffness with marine n-3 fatty acids (Fas) in the general population. The aim of this study was to determine the combined and independent associations of 2 major marine n-3 FAs, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), with aortic stiffness evaluated using carotid-femoral pulse wave velocity (cfPWV) in Korean, white, and Japanese American men.METHODS: A population-based sample of 851 middle-aged men (299 Koreans, 266 whites, and 286 Japanese Americans) was examined for cfPWV during 2002-2006. Serum FAs, including EPA and DHA, were measured as a percentage of total FAs using gas chromatography. Multiple regression analysis was used to examine the association of EPA and DHA with cfPWV after adjusting for blood pressure and other confounders.RESULTS: Mean EPA and DHA levels were 1.9 (SD = 1.0) and 4.8 (SD = 1.4) for Koreans, 0.8 (SD = 0.6) and 2.4 (SD = 1.2) for whites, and 1.0 (SD = 1.0) and 3.2 (SD = 1.4) for Japanese Americans. Both EPA and DHA were significantly higher in Koreans than in the other 2 groups (P <0.01). Multiple regression analyses in Koreans showed that cfPWV had a significant inverse association with total marine n-3 FAs and with EPA alone after adjusting for blood pressure and other potential confounders. In contrast, there was no significant association of cfPWV with DHA. Whites and Japanese Americans did not show any significant associations of cfPWV with total marine n-3 FAs, EPA, or DHA.CONCLUSIONS: High levels of EPA observed in Koreans have an inverse association with aortic stiffness.

AB - BACKGROUND: Few previous studies have reported the association of aortic stiffness with marine n-3 fatty acids (Fas) in the general population. The aim of this study was to determine the combined and independent associations of 2 major marine n-3 FAs, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), with aortic stiffness evaluated using carotid-femoral pulse wave velocity (cfPWV) in Korean, white, and Japanese American men.METHODS: A population-based sample of 851 middle-aged men (299 Koreans, 266 whites, and 286 Japanese Americans) was examined for cfPWV during 2002-2006. Serum FAs, including EPA and DHA, were measured as a percentage of total FAs using gas chromatography. Multiple regression analysis was used to examine the association of EPA and DHA with cfPWV after adjusting for blood pressure and other confounders.RESULTS: Mean EPA and DHA levels were 1.9 (SD = 1.0) and 4.8 (SD = 1.4) for Koreans, 0.8 (SD = 0.6) and 2.4 (SD = 1.2) for whites, and 1.0 (SD = 1.0) and 3.2 (SD = 1.4) for Japanese Americans. Both EPA and DHA were significantly higher in Koreans than in the other 2 groups (P <0.01). Multiple regression analyses in Koreans showed that cfPWV had a significant inverse association with total marine n-3 FAs and with EPA alone after adjusting for blood pressure and other potential confounders. In contrast, there was no significant association of cfPWV with DHA. Whites and Japanese Americans did not show any significant associations of cfPWV with total marine n-3 FAs, EPA, or DHA.CONCLUSIONS: High levels of EPA observed in Koreans have an inverse association with aortic stiffness.

KW - aortic stiffness

KW - blood pressure

KW - carotid femoral pulse wave velocity

KW - docosahexaenoic acid

KW - eicosapentaenoic acid

KW - fish oil

KW - hypertension.

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DO - 10.1093/ajh/hpt107

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JO - American Journal of Hypertension

JF - American Journal of Hypertension

SN - 0895-7061

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