Association study of 11β-hydroxysteroid dehydrogenase type 1 gene polymorphisms and metabolic syndrome in urban Japanese cohort

Yoshihiro Miyamoto, Hiroko Morisaki, Itaru Yamanaka, Yoshihiro Kokubo, Hiroaki Masuzaki, Akira Okayama, Hitonobu Tomoike, Kazuwa Nakao, Tomonori Okamura, Yasunao Yoshimasa, Takayuki Morisaki

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1), one of the isoforms of the 11β-hydroxysteroid dehydrogenase enzymes, acts as an oxo-reductase to reactivate cortisone to cortisol, plays a critical role in tissue-specific corticosteroid reactions, and is therefore a key molecule associated with the development of metabolic syndrome. We investigated whether variations in the 11β-HSD1 gene correlated with metabolic syndrome. We performed case-control study using a population-based urban Japanese cohort. Among 3005 urban residents, we examined 431 subjects diagnosed with metabolic syndrome according to the Japanese definition and 777 subjects with none of metabolic syndrome criteria as control. We genotyped three single nucleotide polymorphisms (SNPs) (+9410T>A, +17925C>T, +27447G>C) across the 11β-HSD1 gene in them and analyzed the associations of SNPs and haplotypes with metabolic syndrome. The +9410A allele showed a tendency to metabolic syndrome (OR = 1.5, 95%C.I., 1.0-2.2; P = 0.041 and Bonferroni corrected P = 0.123) without statistical significance. However, we could not find any significant association between metabolic syndrome and SNPs in the 11β-HSD1 gene. Our findings indicate that polymorphisms and haplotypes in the 11β-HSD1 gene are not significantly associated with metabolic syndrome in the Japanese population.

Original languageEnglish
Pages (from-to)132-138
Number of pages7
JournalDiabetes Research and Clinical Practice
Volume85
Issue number2
DOIs
Publication statusPublished - 2009 Aug
Externally publishedYes

Fingerprint

11-beta-Hydroxysteroid Dehydrogenases
Genes
Single Nucleotide Polymorphism
Haplotypes
Urban Population
Cortisone
Hydrocortisone
Case-Control Studies
Adrenal Cortex Hormones
Oxidoreductases
Protein Isoforms
Alleles

Keywords

  • 11β-Hydroxysteroid dehydrogenase type 1
  • Haplotype
  • Japanese
  • Metabolic syndrome
  • Single nucleotide polymorphism

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine
  • Endocrinology

Cite this

Association study of 11β-hydroxysteroid dehydrogenase type 1 gene polymorphisms and metabolic syndrome in urban Japanese cohort. / Miyamoto, Yoshihiro; Morisaki, Hiroko; Yamanaka, Itaru; Kokubo, Yoshihiro; Masuzaki, Hiroaki; Okayama, Akira; Tomoike, Hitonobu; Nakao, Kazuwa; Okamura, Tomonori; Yoshimasa, Yasunao; Morisaki, Takayuki.

In: Diabetes Research and Clinical Practice, Vol. 85, No. 2, 08.2009, p. 132-138.

Research output: Contribution to journalArticle

Miyamoto, Y, Morisaki, H, Yamanaka, I, Kokubo, Y, Masuzaki, H, Okayama, A, Tomoike, H, Nakao, K, Okamura, T, Yoshimasa, Y & Morisaki, T 2009, 'Association study of 11β-hydroxysteroid dehydrogenase type 1 gene polymorphisms and metabolic syndrome in urban Japanese cohort', Diabetes Research and Clinical Practice, vol. 85, no. 2, pp. 132-138. https://doi.org/10.1016/j.diabres.2009.05.017
Miyamoto, Yoshihiro ; Morisaki, Hiroko ; Yamanaka, Itaru ; Kokubo, Yoshihiro ; Masuzaki, Hiroaki ; Okayama, Akira ; Tomoike, Hitonobu ; Nakao, Kazuwa ; Okamura, Tomonori ; Yoshimasa, Yasunao ; Morisaki, Takayuki. / Association study of 11β-hydroxysteroid dehydrogenase type 1 gene polymorphisms and metabolic syndrome in urban Japanese cohort. In: Diabetes Research and Clinical Practice. 2009 ; Vol. 85, No. 2. pp. 132-138.
@article{c4be684a8aea452387b0440bc3ca4d74,
title = "Association study of 11β-hydroxysteroid dehydrogenase type 1 gene polymorphisms and metabolic syndrome in urban Japanese cohort",
abstract = "11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1), one of the isoforms of the 11β-hydroxysteroid dehydrogenase enzymes, acts as an oxo-reductase to reactivate cortisone to cortisol, plays a critical role in tissue-specific corticosteroid reactions, and is therefore a key molecule associated with the development of metabolic syndrome. We investigated whether variations in the 11β-HSD1 gene correlated with metabolic syndrome. We performed case-control study using a population-based urban Japanese cohort. Among 3005 urban residents, we examined 431 subjects diagnosed with metabolic syndrome according to the Japanese definition and 777 subjects with none of metabolic syndrome criteria as control. We genotyped three single nucleotide polymorphisms (SNPs) (+9410T>A, +17925C>T, +27447G>C) across the 11β-HSD1 gene in them and analyzed the associations of SNPs and haplotypes with metabolic syndrome. The +9410A allele showed a tendency to metabolic syndrome (OR = 1.5, 95{\%}C.I., 1.0-2.2; P = 0.041 and Bonferroni corrected P = 0.123) without statistical significance. However, we could not find any significant association between metabolic syndrome and SNPs in the 11β-HSD1 gene. Our findings indicate that polymorphisms and haplotypes in the 11β-HSD1 gene are not significantly associated with metabolic syndrome in the Japanese population.",
keywords = "11β-Hydroxysteroid dehydrogenase type 1, Haplotype, Japanese, Metabolic syndrome, Single nucleotide polymorphism",
author = "Yoshihiro Miyamoto and Hiroko Morisaki and Itaru Yamanaka and Yoshihiro Kokubo and Hiroaki Masuzaki and Akira Okayama and Hitonobu Tomoike and Kazuwa Nakao and Tomonori Okamura and Yasunao Yoshimasa and Takayuki Morisaki",
year = "2009",
month = "8",
doi = "10.1016/j.diabres.2009.05.017",
language = "English",
volume = "85",
pages = "132--138",
journal = "Diabetes Research and Clinical Practice",
issn = "0168-8227",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Association study of 11β-hydroxysteroid dehydrogenase type 1 gene polymorphisms and metabolic syndrome in urban Japanese cohort

AU - Miyamoto, Yoshihiro

AU - Morisaki, Hiroko

AU - Yamanaka, Itaru

AU - Kokubo, Yoshihiro

AU - Masuzaki, Hiroaki

AU - Okayama, Akira

AU - Tomoike, Hitonobu

AU - Nakao, Kazuwa

AU - Okamura, Tomonori

AU - Yoshimasa, Yasunao

AU - Morisaki, Takayuki

PY - 2009/8

Y1 - 2009/8

N2 - 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1), one of the isoforms of the 11β-hydroxysteroid dehydrogenase enzymes, acts as an oxo-reductase to reactivate cortisone to cortisol, plays a critical role in tissue-specific corticosteroid reactions, and is therefore a key molecule associated with the development of metabolic syndrome. We investigated whether variations in the 11β-HSD1 gene correlated with metabolic syndrome. We performed case-control study using a population-based urban Japanese cohort. Among 3005 urban residents, we examined 431 subjects diagnosed with metabolic syndrome according to the Japanese definition and 777 subjects with none of metabolic syndrome criteria as control. We genotyped three single nucleotide polymorphisms (SNPs) (+9410T>A, +17925C>T, +27447G>C) across the 11β-HSD1 gene in them and analyzed the associations of SNPs and haplotypes with metabolic syndrome. The +9410A allele showed a tendency to metabolic syndrome (OR = 1.5, 95%C.I., 1.0-2.2; P = 0.041 and Bonferroni corrected P = 0.123) without statistical significance. However, we could not find any significant association between metabolic syndrome and SNPs in the 11β-HSD1 gene. Our findings indicate that polymorphisms and haplotypes in the 11β-HSD1 gene are not significantly associated with metabolic syndrome in the Japanese population.

AB - 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1), one of the isoforms of the 11β-hydroxysteroid dehydrogenase enzymes, acts as an oxo-reductase to reactivate cortisone to cortisol, plays a critical role in tissue-specific corticosteroid reactions, and is therefore a key molecule associated with the development of metabolic syndrome. We investigated whether variations in the 11β-HSD1 gene correlated with metabolic syndrome. We performed case-control study using a population-based urban Japanese cohort. Among 3005 urban residents, we examined 431 subjects diagnosed with metabolic syndrome according to the Japanese definition and 777 subjects with none of metabolic syndrome criteria as control. We genotyped three single nucleotide polymorphisms (SNPs) (+9410T>A, +17925C>T, +27447G>C) across the 11β-HSD1 gene in them and analyzed the associations of SNPs and haplotypes with metabolic syndrome. The +9410A allele showed a tendency to metabolic syndrome (OR = 1.5, 95%C.I., 1.0-2.2; P = 0.041 and Bonferroni corrected P = 0.123) without statistical significance. However, we could not find any significant association between metabolic syndrome and SNPs in the 11β-HSD1 gene. Our findings indicate that polymorphisms and haplotypes in the 11β-HSD1 gene are not significantly associated with metabolic syndrome in the Japanese population.

KW - 11β-Hydroxysteroid dehydrogenase type 1

KW - Haplotype

KW - Japanese

KW - Metabolic syndrome

KW - Single nucleotide polymorphism

UR - http://www.scopus.com/inward/record.url?scp=67649850374&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67649850374&partnerID=8YFLogxK

U2 - 10.1016/j.diabres.2009.05.017

DO - 10.1016/j.diabres.2009.05.017

M3 - Article

C2 - 19535162

AN - SCOPUS:67649850374

VL - 85

SP - 132

EP - 138

JO - Diabetes Research and Clinical Practice

JF - Diabetes Research and Clinical Practice

SN - 0168-8227

IS - 2

ER -