Association study of 11β-hydroxysteroid dehydrogenase type 1 gene polymorphisms and metabolic syndrome in urban Japanese cohort

Yoshihiro Miyamoto, Hiroko Morisaki, Itaru Yamanaka, Yoshihiro Kokubo, Hiroaki Masuzaki, Akira Okayama, Hitonobu Tomoike, Kazuwa Nakao, Tomonori Okamura, Yasunao Yoshimasa, Takayuki Morisaki

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1), one of the isoforms of the 11β-hydroxysteroid dehydrogenase enzymes, acts as an oxo-reductase to reactivate cortisone to cortisol, plays a critical role in tissue-specific corticosteroid reactions, and is therefore a key molecule associated with the development of metabolic syndrome. We investigated whether variations in the 11β-HSD1 gene correlated with metabolic syndrome. We performed case-control study using a population-based urban Japanese cohort. Among 3005 urban residents, we examined 431 subjects diagnosed with metabolic syndrome according to the Japanese definition and 777 subjects with none of metabolic syndrome criteria as control. We genotyped three single nucleotide polymorphisms (SNPs) (+9410T>A, +17925C>T, +27447G>C) across the 11β-HSD1 gene in them and analyzed the associations of SNPs and haplotypes with metabolic syndrome. The +9410A allele showed a tendency to metabolic syndrome (OR = 1.5, 95%C.I., 1.0-2.2; P = 0.041 and Bonferroni corrected P = 0.123) without statistical significance. However, we could not find any significant association between metabolic syndrome and SNPs in the 11β-HSD1 gene. Our findings indicate that polymorphisms and haplotypes in the 11β-HSD1 gene are not significantly associated with metabolic syndrome in the Japanese population.

Original languageEnglish
Pages (from-to)132-138
Number of pages7
JournalDiabetes Research and Clinical Practice
Volume85
Issue number2
DOIs
Publication statusPublished - 2009 Aug 1
Externally publishedYes

Keywords

  • 11β-Hydroxysteroid dehydrogenase type 1
  • Haplotype
  • Japanese
  • Metabolic syndrome
  • Single nucleotide polymorphism

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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