Association with serum gamma-glutamyltransferase levels and alcohol consumption on stroke and coronary artery disease: The suita study

Aya Higashiyama, Ichiro Wakabayashi, Yuu Ono, Makoto Watanabe, Yoshihiro Kokubo, Akira Okayama, Yoshihiro Miyamoto, Tomonori Okamura

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14 Citations (Scopus)


Background And Purpose- Light-to-moderate alcohol consumption is associated with reduced risk for cardiovascular disease, whereas high serum γ-glutamyltransferase (GGT) level is associated with cardiovascular disease. However, whether light-to-moderate alcohol drinking is still related to reduced risk of cardiovascular disease irrespective of GGT level is uncertain. Methods- We performed a 12.5-year cohort study of 2336 men (excluding exdrinkers) who were free from cardiovascular disease. They were classified into 4 groups according to alcohol consumption: never, and current light, moderate, or heavy drinker. The multivariate-adjusted hazard ratios of alcohol consumption for incidence of coronary artery disease, total stroke, and ischemic stroke compared with those of never drinkers were assessed with stratification by GGT median (32 IU/L). Results- In participants with GGT >32 IU/L, the hazard ratios of all current drinkers for total and ischemic stroke were higher than those of never drinkers. However, in all current drinkers with GGT ≤32 IU/L, the multivariate-adjusted hazard ratios for total and ischemic stroke were lower than in never drinkers. Conclusions- In men with above GGT median, alcohol drinking even with light-to-moderate consumption could be a risk factor for ischemic stroke.

Original languageEnglish
Pages (from-to)1764-1767
Number of pages4
Issue number6
Publication statusPublished - 2011 Jun 1



  • cohort
  • epidemiology
  • incidence
  • ischemic stroke

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialised Nursing

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