Associations between capsular serotype, multilocus sequence type, and macrolide resistance in Streptococcus agalactiae isolates from Japanese infants with invasive infections

M. Morozumi, T. Wajima, Y. Kuwata, N. Chiba, K. Sunaoshi, K. Sugita, H. Sakata, S. Iwata, K. Ubukata

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Streptococcus agalactiae (group B streptococcus; GBS) isolates (n = 150) from infants with invasive infections between 2006 and 2011 were analysed for capsular serotype, multilocus sequence type, and antibiotic susceptibility. In cases with late-onset disease (n = 115), primary meningitis was predominant (62·6%), but represented only 39·1% in cases with early-onset disease (n = 23). The most common serotype was III (58·7%), followed by Ia (21·3%) and Ib (12·7%). Sequence types (STs) of serotype III strains included ST17 (50·0%), ST19 (26·1%), ST335 (18·2%), ST27 (4·5%), and ST1 (1·1%). Predominant STs of serotypes Ia and Ib were ST23 (81·3%) and ST10 (84·2%), respectively. No penicillin-resistant strains were detected, but 22·0% of strains had mef(A/E), erm(A), or erm(B) genes, which mediate macrolide resistance. A new ST335, possessing an mef(A/E) gene belonging to clonal complex 19 gradually increased in frequency. Improved prevention of invasive GBS infections in infants requires timely identification, and ultimately vaccine development.

Original languageEnglish
Pages (from-to)812-819
Number of pages8
JournalEpidemiology and Infection
Volume142
Issue number4
DOIs
Publication statusPublished - 2014 Apr

Keywords

  • Capsular type
  • Streptococcus agalactiae
  • invasive diseases
  • multilocus sequence typing
  • neonates

ASJC Scopus subject areas

  • Epidemiology
  • Infectious Diseases

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