Associations between capsular serotype, multilocus sequence type, and macrolide resistance in Streptococcus agalactiae isolates from Japanese infants with invasive infections

Miyuki Morozumi, T. Wajima, Y. Kuwata, N. Chiba, K. Sunaoshi, K. Sugita, H. Sakata, S. Iwata, K. Ubukata

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Streptococcus agalactiae (group B streptococcus; GBS) isolates (n = 150) from infants with invasive infections between 2006 and 2011 were analysed for capsular serotype, multilocus sequence type, and antibiotic susceptibility. In cases with late-onset disease (n = 115), primary meningitis was predominant (62·6%), but represented only 39·1% in cases with early-onset disease (n = 23). The most common serotype was III (58·7%), followed by Ia (21·3%) and Ib (12·7%). Sequence types (STs) of serotype III strains included ST17 (50·0%), ST19 (26·1%), ST335 (18·2%), ST27 (4·5%), and ST1 (1·1%). Predominant STs of serotypes Ia and Ib were ST23 (81·3%) and ST10 (84·2%), respectively. No penicillin-resistant strains were detected, but 22·0% of strains had mef(A/E), erm(A), or erm(B) genes, which mediate macrolide resistance. A new ST335, possessing an mef(A/E) gene belonging to clonal complex 19 gradually increased in frequency. Improved prevention of invasive GBS infections in infants requires timely identification, and ultimately vaccine development.

Original languageEnglish
Pages (from-to)812-819
Number of pages8
JournalEpidemiology and Infection
Volume142
Issue number4
DOIs
Publication statusPublished - 2014
Externally publishedYes

Fingerprint

Streptococcus agalactiae
Macrolides
Infection
Streptococcus
Meningitis
Penicillins
Genes
Vaccines
Anti-Bacterial Agents
Serogroup

Keywords

  • Capsular type
  • invasive diseases
  • multilocus sequence typing
  • neonates
  • Streptococcus agalactiae

ASJC Scopus subject areas

  • Infectious Diseases
  • Epidemiology

Cite this

Associations between capsular serotype, multilocus sequence type, and macrolide resistance in Streptococcus agalactiae isolates from Japanese infants with invasive infections. / Morozumi, Miyuki; Wajima, T.; Kuwata, Y.; Chiba, N.; Sunaoshi, K.; Sugita, K.; Sakata, H.; Iwata, S.; Ubukata, K.

In: Epidemiology and Infection, Vol. 142, No. 4, 2014, p. 812-819.

Research output: Contribution to journalArticle

Morozumi, Miyuki ; Wajima, T. ; Kuwata, Y. ; Chiba, N. ; Sunaoshi, K. ; Sugita, K. ; Sakata, H. ; Iwata, S. ; Ubukata, K. / Associations between capsular serotype, multilocus sequence type, and macrolide resistance in Streptococcus agalactiae isolates from Japanese infants with invasive infections. In: Epidemiology and Infection. 2014 ; Vol. 142, No. 4. pp. 812-819.
@article{bbd6a710c72d4b719f124dcc28e1606a,
title = "Associations between capsular serotype, multilocus sequence type, and macrolide resistance in Streptococcus agalactiae isolates from Japanese infants with invasive infections",
abstract = "Streptococcus agalactiae (group B streptococcus; GBS) isolates (n = 150) from infants with invasive infections between 2006 and 2011 were analysed for capsular serotype, multilocus sequence type, and antibiotic susceptibility. In cases with late-onset disease (n = 115), primary meningitis was predominant (62·6{\%}), but represented only 39·1{\%} in cases with early-onset disease (n = 23). The most common serotype was III (58·7{\%}), followed by Ia (21·3{\%}) and Ib (12·7{\%}). Sequence types (STs) of serotype III strains included ST17 (50·0{\%}), ST19 (26·1{\%}), ST335 (18·2{\%}), ST27 (4·5{\%}), and ST1 (1·1{\%}). Predominant STs of serotypes Ia and Ib were ST23 (81·3{\%}) and ST10 (84·2{\%}), respectively. No penicillin-resistant strains were detected, but 22·0{\%} of strains had mef(A/E), erm(A), or erm(B) genes, which mediate macrolide resistance. A new ST335, possessing an mef(A/E) gene belonging to clonal complex 19 gradually increased in frequency. Improved prevention of invasive GBS infections in infants requires timely identification, and ultimately vaccine development.",
keywords = "Capsular type, invasive diseases, multilocus sequence typing, neonates, Streptococcus agalactiae",
author = "Miyuki Morozumi and T. Wajima and Y. Kuwata and N. Chiba and K. Sunaoshi and K. Sugita and H. Sakata and S. Iwata and K. Ubukata",
year = "2014",
doi = "10.1017/S0950268813001647",
language = "English",
volume = "142",
pages = "812--819",
journal = "Epidemiology and Infection",
issn = "0950-2688",
publisher = "Cambridge University Press",
number = "4",

}

TY - JOUR

T1 - Associations between capsular serotype, multilocus sequence type, and macrolide resistance in Streptococcus agalactiae isolates from Japanese infants with invasive infections

AU - Morozumi, Miyuki

AU - Wajima, T.

AU - Kuwata, Y.

AU - Chiba, N.

AU - Sunaoshi, K.

AU - Sugita, K.

AU - Sakata, H.

AU - Iwata, S.

AU - Ubukata, K.

PY - 2014

Y1 - 2014

N2 - Streptococcus agalactiae (group B streptococcus; GBS) isolates (n = 150) from infants with invasive infections between 2006 and 2011 were analysed for capsular serotype, multilocus sequence type, and antibiotic susceptibility. In cases with late-onset disease (n = 115), primary meningitis was predominant (62·6%), but represented only 39·1% in cases with early-onset disease (n = 23). The most common serotype was III (58·7%), followed by Ia (21·3%) and Ib (12·7%). Sequence types (STs) of serotype III strains included ST17 (50·0%), ST19 (26·1%), ST335 (18·2%), ST27 (4·5%), and ST1 (1·1%). Predominant STs of serotypes Ia and Ib were ST23 (81·3%) and ST10 (84·2%), respectively. No penicillin-resistant strains were detected, but 22·0% of strains had mef(A/E), erm(A), or erm(B) genes, which mediate macrolide resistance. A new ST335, possessing an mef(A/E) gene belonging to clonal complex 19 gradually increased in frequency. Improved prevention of invasive GBS infections in infants requires timely identification, and ultimately vaccine development.

AB - Streptococcus agalactiae (group B streptococcus; GBS) isolates (n = 150) from infants with invasive infections between 2006 and 2011 were analysed for capsular serotype, multilocus sequence type, and antibiotic susceptibility. In cases with late-onset disease (n = 115), primary meningitis was predominant (62·6%), but represented only 39·1% in cases with early-onset disease (n = 23). The most common serotype was III (58·7%), followed by Ia (21·3%) and Ib (12·7%). Sequence types (STs) of serotype III strains included ST17 (50·0%), ST19 (26·1%), ST335 (18·2%), ST27 (4·5%), and ST1 (1·1%). Predominant STs of serotypes Ia and Ib were ST23 (81·3%) and ST10 (84·2%), respectively. No penicillin-resistant strains were detected, but 22·0% of strains had mef(A/E), erm(A), or erm(B) genes, which mediate macrolide resistance. A new ST335, possessing an mef(A/E) gene belonging to clonal complex 19 gradually increased in frequency. Improved prevention of invasive GBS infections in infants requires timely identification, and ultimately vaccine development.

KW - Capsular type

KW - invasive diseases

KW - multilocus sequence typing

KW - neonates

KW - Streptococcus agalactiae

UR - http://www.scopus.com/inward/record.url?scp=84901721885&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84901721885&partnerID=8YFLogxK

U2 - 10.1017/S0950268813001647

DO - 10.1017/S0950268813001647

M3 - Article

VL - 142

SP - 812

EP - 819

JO - Epidemiology and Infection

JF - Epidemiology and Infection

SN - 0950-2688

IS - 4

ER -