Associations between inflammatory markers and subclinical atherosclerosis in middle-aged white, Japanese-American and Japanese men: The ERA-JUMP study

Shin Ya Nagasawa, Takayoshi Ohkubo, Kamal Masaki, Emma Barinas-Mitchell, Katsuyuki Miura, Todd B. Seto, Aiman El-Saed, Takashi Kadowaki, Bradley J. Willcox, Daniel Edmundowicz, Aya Kadota, Rhobert W. Evans, Sayaka Kadowaki, Akira Fujiyoshi, Takashi Hisamatsu, Marianne H. Bertolet, Tomonori Okamura, Yasuyuki Nakamura, Lewis H. Kuller, Hirotsugu UeshimaAkira Sekikawa

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Aim: To examine whether the inflammatory markers C-reactive protein (CRP) and fibrinogen are associated with biomarkers of atherosclerosis [carotid intima-media thickness (IMT) and coronary artery calcification (CAC)] in the general male population, including Asians. Methods: Population-based samples of 310 Japanese, 293 Japanese-American and 297 white men 40-49 years of age without clinical cardiovascular disease underwent measurement of IMT, CAC and the CRP and fibrinogen levels as well as other conventional risk factors using standardized methods. Statistical associations between the variables were evaluated using multiple linear or logistic regression models. Results: The Japanese group had significantly lower levels of inflammatory markers and subclinical atherosclerosis than the Japanese-American and white groups (P-values all <0.001). The mean level of CRP was 0.66 vs. 1.11 and 1.47 mg/L, while that of fibrinogen was 255.0 vs. 313.0 and 291.5 mg/dl, respectively. In addition, the mean carotid IMT was 0.61 vs. 0.73 and 0.68 mm, while the mean prevalence of CAC was 11.6% vs. 32.1% and 26.3%, respectively. Body mass index (BMI) showed significant positive associations with both the CRP and fibrinogen levels. Although CRP showed a significant positive association with IMT in the Japanese men, this association became non-significant following adjustment for traditional risk factors or BMI. In all three populations, CRP was not found to be significantly associated with the prevalence of CAC. Similarly, fibrinogen did not exhibit a significant association with either IMT or the prevalence of CAC. Conclusions: The associations between inflammatory markers and subclinical atherosclerosis may merely reflect the strong associations between BMI and the levels of inflammatory markers and incidence of subclinical atherosclerosis in both Eastern and Western populations.

Original languageEnglish
Pages (from-to)590-598
Number of pages9
JournalJournal of Atherosclerosis and Thrombosis
Volume22
Issue number6
Publication statusPublished - 2015 May 27

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Asian Americans
C-Reactive Protein
Atherosclerosis
Fibrinogen
Coronary Vessels
Carotid Intima-Media Thickness
Body Mass Index
Association reactions
Population
Logistic Models
Biomarkers
Logistics
Linear Models
Cardiovascular Diseases
Incidence

Keywords

  • C-reactive protein
  • Coronary artery calcification
  • Fibrinogen
  • Intima-media thickness
  • Obesity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Internal Medicine
  • Biochemistry, medical

Cite this

Nagasawa, S. Y., Ohkubo, T., Masaki, K., Barinas-Mitchell, E., Miura, K., Seto, T. B., ... Sekikawa, A. (2015). Associations between inflammatory markers and subclinical atherosclerosis in middle-aged white, Japanese-American and Japanese men: The ERA-JUMP study. Journal of Atherosclerosis and Thrombosis, 22(6), 590-598.

Associations between inflammatory markers and subclinical atherosclerosis in middle-aged white, Japanese-American and Japanese men : The ERA-JUMP study. / Nagasawa, Shin Ya; Ohkubo, Takayoshi; Masaki, Kamal; Barinas-Mitchell, Emma; Miura, Katsuyuki; Seto, Todd B.; El-Saed, Aiman; Kadowaki, Takashi; Willcox, Bradley J.; Edmundowicz, Daniel; Kadota, Aya; Evans, Rhobert W.; Kadowaki, Sayaka; Fujiyoshi, Akira; Hisamatsu, Takashi; Bertolet, Marianne H.; Okamura, Tomonori; Nakamura, Yasuyuki; Kuller, Lewis H.; Ueshima, Hirotsugu; Sekikawa, Akira.

In: Journal of Atherosclerosis and Thrombosis, Vol. 22, No. 6, 27.05.2015, p. 590-598.

Research output: Contribution to journalArticle

Nagasawa, SY, Ohkubo, T, Masaki, K, Barinas-Mitchell, E, Miura, K, Seto, TB, El-Saed, A, Kadowaki, T, Willcox, BJ, Edmundowicz, D, Kadota, A, Evans, RW, Kadowaki, S, Fujiyoshi, A, Hisamatsu, T, Bertolet, MH, Okamura, T, Nakamura, Y, Kuller, LH, Ueshima, H & Sekikawa, A 2015, 'Associations between inflammatory markers and subclinical atherosclerosis in middle-aged white, Japanese-American and Japanese men: The ERA-JUMP study', Journal of Atherosclerosis and Thrombosis, vol. 22, no. 6, pp. 590-598.
Nagasawa, Shin Ya ; Ohkubo, Takayoshi ; Masaki, Kamal ; Barinas-Mitchell, Emma ; Miura, Katsuyuki ; Seto, Todd B. ; El-Saed, Aiman ; Kadowaki, Takashi ; Willcox, Bradley J. ; Edmundowicz, Daniel ; Kadota, Aya ; Evans, Rhobert W. ; Kadowaki, Sayaka ; Fujiyoshi, Akira ; Hisamatsu, Takashi ; Bertolet, Marianne H. ; Okamura, Tomonori ; Nakamura, Yasuyuki ; Kuller, Lewis H. ; Ueshima, Hirotsugu ; Sekikawa, Akira. / Associations between inflammatory markers and subclinical atherosclerosis in middle-aged white, Japanese-American and Japanese men : The ERA-JUMP study. In: Journal of Atherosclerosis and Thrombosis. 2015 ; Vol. 22, No. 6. pp. 590-598.
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abstract = "Aim: To examine whether the inflammatory markers C-reactive protein (CRP) and fibrinogen are associated with biomarkers of atherosclerosis [carotid intima-media thickness (IMT) and coronary artery calcification (CAC)] in the general male population, including Asians. Methods: Population-based samples of 310 Japanese, 293 Japanese-American and 297 white men 40-49 years of age without clinical cardiovascular disease underwent measurement of IMT, CAC and the CRP and fibrinogen levels as well as other conventional risk factors using standardized methods. Statistical associations between the variables were evaluated using multiple linear or logistic regression models. Results: The Japanese group had significantly lower levels of inflammatory markers and subclinical atherosclerosis than the Japanese-American and white groups (P-values all <0.001). The mean level of CRP was 0.66 vs. 1.11 and 1.47 mg/L, while that of fibrinogen was 255.0 vs. 313.0 and 291.5 mg/dl, respectively. In addition, the mean carotid IMT was 0.61 vs. 0.73 and 0.68 mm, while the mean prevalence of CAC was 11.6{\%} vs. 32.1{\%} and 26.3{\%}, respectively. Body mass index (BMI) showed significant positive associations with both the CRP and fibrinogen levels. Although CRP showed a significant positive association with IMT in the Japanese men, this association became non-significant following adjustment for traditional risk factors or BMI. In all three populations, CRP was not found to be significantly associated with the prevalence of CAC. Similarly, fibrinogen did not exhibit a significant association with either IMT or the prevalence of CAC. Conclusions: The associations between inflammatory markers and subclinical atherosclerosis may merely reflect the strong associations between BMI and the levels of inflammatory markers and incidence of subclinical atherosclerosis in both Eastern and Western populations.",
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T1 - Associations between inflammatory markers and subclinical atherosclerosis in middle-aged white, Japanese-American and Japanese men

T2 - The ERA-JUMP study

AU - Nagasawa, Shin Ya

AU - Ohkubo, Takayoshi

AU - Masaki, Kamal

AU - Barinas-Mitchell, Emma

AU - Miura, Katsuyuki

AU - Seto, Todd B.

AU - El-Saed, Aiman

AU - Kadowaki, Takashi

AU - Willcox, Bradley J.

AU - Edmundowicz, Daniel

AU - Kadota, Aya

AU - Evans, Rhobert W.

AU - Kadowaki, Sayaka

AU - Fujiyoshi, Akira

AU - Hisamatsu, Takashi

AU - Bertolet, Marianne H.

AU - Okamura, Tomonori

AU - Nakamura, Yasuyuki

AU - Kuller, Lewis H.

AU - Ueshima, Hirotsugu

AU - Sekikawa, Akira

PY - 2015/5/27

Y1 - 2015/5/27

N2 - Aim: To examine whether the inflammatory markers C-reactive protein (CRP) and fibrinogen are associated with biomarkers of atherosclerosis [carotid intima-media thickness (IMT) and coronary artery calcification (CAC)] in the general male population, including Asians. Methods: Population-based samples of 310 Japanese, 293 Japanese-American and 297 white men 40-49 years of age without clinical cardiovascular disease underwent measurement of IMT, CAC and the CRP and fibrinogen levels as well as other conventional risk factors using standardized methods. Statistical associations between the variables were evaluated using multiple linear or logistic regression models. Results: The Japanese group had significantly lower levels of inflammatory markers and subclinical atherosclerosis than the Japanese-American and white groups (P-values all <0.001). The mean level of CRP was 0.66 vs. 1.11 and 1.47 mg/L, while that of fibrinogen was 255.0 vs. 313.0 and 291.5 mg/dl, respectively. In addition, the mean carotid IMT was 0.61 vs. 0.73 and 0.68 mm, while the mean prevalence of CAC was 11.6% vs. 32.1% and 26.3%, respectively. Body mass index (BMI) showed significant positive associations with both the CRP and fibrinogen levels. Although CRP showed a significant positive association with IMT in the Japanese men, this association became non-significant following adjustment for traditional risk factors or BMI. In all three populations, CRP was not found to be significantly associated with the prevalence of CAC. Similarly, fibrinogen did not exhibit a significant association with either IMT or the prevalence of CAC. Conclusions: The associations between inflammatory markers and subclinical atherosclerosis may merely reflect the strong associations between BMI and the levels of inflammatory markers and incidence of subclinical atherosclerosis in both Eastern and Western populations.

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KW - Coronary artery calcification

KW - Fibrinogen

KW - Intima-media thickness

KW - Obesity

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