Associations of Overweight, Obesity, and Underweight With High Serum Total Cholesterol Level Over 30 Years Among the Japanese Elderly

NIPPON DATA 80, 90, and 2010

Yosuke Shibata, Toshiyuki Ojima, Mieko Nakamura, Kazuyo Kuwabara, Naoko Miyagawa, Yoshino Saito, Yasuyuki Nakamura, Yutaka Kiyohara, Hideaki Nakagawa, Akira Fujiyoshi, Aya Kadota, Takayoshi Ohkubo, Tomonori Okamura, Hirotsugu Ueshima, Akira Okayama, Katsuyuki Miura

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

BACKGROUND: The trend of association between overweight and high serum total cholesterol (TC) among the elderly is unclear. In addition, there is little evidence of risk of underweight for high TC. Therefore, we examined the trend of association of overweight or underweight with high TC among Japanese elderly people using nationwide population-based data. METHODS: Data of the National Survey on Circulatory Disorders and National Health and Nutrition Survey for 1980, 1990, 2000, and 2010 were used in the analysis. High TC was defined as 220 mg/dL and above. For participants aged ≥50 years, sex-specific odds ratios (ORs) of overweight or underweight compared with normal body mass index participants for high TC were calculated using a logistic regression model adjusted for age, smoking, drinking, exercise, food, and treatment of hyperlipidemia. RESULTS: A total of 5,734, 4,673, 5,059, and 2,105 participants enrolled in these surveys in 1980, 1990, 2000, and 2010, respectively. Although overweight was positively and significantly associated with high TC in 1980, the association has gradually weakened since (ORs in 1980 and 2010 were 2.44; 95% confidence interval [CI], 1.83-3.24 and 0.92; 95% CI, 0.66-1.27 among men and 1.43; 95% CI, 1.18-1.72 and 1.08; 95% CI, 0.81-1.44 among women, respectively). While underweight was inversely and significantly associated with high TC in 1980, the association also gradually weakened among women (ORs in 1980 and 2010 were 0.28; 95% CI, 0.12-0.60 and 0.37; 95% CI, 0.10-1.28 among men and 0.39; 95% CI, 0.26-0.57 and 0.96; 95% CI, 0.58-1.57 among women, respectively). CONCLUSIONS: These findings provide evidence that high TC prevention efforts must expand the target to not only overweight but also to normal and underweight people.

Original languageEnglish
Pages (from-to)133-138
Number of pages6
JournalJournal of epidemiology
Volume29
Issue number4
DOIs
Publication statusPublished - 2019 Apr 5

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Thinness
Obesity
Cholesterol
Confidence Intervals
Serum
Odds Ratio
Logistic Models
Nutrition Surveys
Hyperlipidemias
Health Surveys
Drinking
Body Mass Index
Smoking
Exercise
Food

Keywords

  • body mass index
  • hyperlipidemias
  • Japan
  • overweight
  • thinness

ASJC Scopus subject areas

  • Epidemiology

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Associations of Overweight, Obesity, and Underweight With High Serum Total Cholesterol Level Over 30 Years Among the Japanese Elderly : NIPPON DATA 80, 90, and 2010. / Shibata, Yosuke; Ojima, Toshiyuki; Nakamura, Mieko; Kuwabara, Kazuyo; Miyagawa, Naoko; Saito, Yoshino; Nakamura, Yasuyuki; Kiyohara, Yutaka; Nakagawa, Hideaki; Fujiyoshi, Akira; Kadota, Aya; Ohkubo, Takayoshi; Okamura, Tomonori; Ueshima, Hirotsugu; Okayama, Akira; Miura, Katsuyuki.

In: Journal of epidemiology, Vol. 29, No. 4, 05.04.2019, p. 133-138.

Research output: Contribution to journalArticle

Shibata, Y, Ojima, T, Nakamura, M, Kuwabara, K, Miyagawa, N, Saito, Y, Nakamura, Y, Kiyohara, Y, Nakagawa, H, Fujiyoshi, A, Kadota, A, Ohkubo, T, Okamura, T, Ueshima, H, Okayama, A & Miura, K 2019, 'Associations of Overweight, Obesity, and Underweight With High Serum Total Cholesterol Level Over 30 Years Among the Japanese Elderly: NIPPON DATA 80, 90, and 2010', Journal of epidemiology, vol. 29, no. 4, pp. 133-138. https://doi.org/10.2188/jea.JE20170229
Shibata, Yosuke ; Ojima, Toshiyuki ; Nakamura, Mieko ; Kuwabara, Kazuyo ; Miyagawa, Naoko ; Saito, Yoshino ; Nakamura, Yasuyuki ; Kiyohara, Yutaka ; Nakagawa, Hideaki ; Fujiyoshi, Akira ; Kadota, Aya ; Ohkubo, Takayoshi ; Okamura, Tomonori ; Ueshima, Hirotsugu ; Okayama, Akira ; Miura, Katsuyuki. / Associations of Overweight, Obesity, and Underweight With High Serum Total Cholesterol Level Over 30 Years Among the Japanese Elderly : NIPPON DATA 80, 90, and 2010. In: Journal of epidemiology. 2019 ; Vol. 29, No. 4. pp. 133-138.
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abstract = "BACKGROUND: The trend of association between overweight and high serum total cholesterol (TC) among the elderly is unclear. In addition, there is little evidence of risk of underweight for high TC. Therefore, we examined the trend of association of overweight or underweight with high TC among Japanese elderly people using nationwide population-based data. METHODS: Data of the National Survey on Circulatory Disorders and National Health and Nutrition Survey for 1980, 1990, 2000, and 2010 were used in the analysis. High TC was defined as 220 mg/dL and above. For participants aged ≥50 years, sex-specific odds ratios (ORs) of overweight or underweight compared with normal body mass index participants for high TC were calculated using a logistic regression model adjusted for age, smoking, drinking, exercise, food, and treatment of hyperlipidemia. RESULTS: A total of 5,734, 4,673, 5,059, and 2,105 participants enrolled in these surveys in 1980, 1990, 2000, and 2010, respectively. Although overweight was positively and significantly associated with high TC in 1980, the association has gradually weakened since (ORs in 1980 and 2010 were 2.44; 95{\%} confidence interval [CI], 1.83-3.24 and 0.92; 95{\%} CI, 0.66-1.27 among men and 1.43; 95{\%} CI, 1.18-1.72 and 1.08; 95{\%} CI, 0.81-1.44 among women, respectively). While underweight was inversely and significantly associated with high TC in 1980, the association also gradually weakened among women (ORs in 1980 and 2010 were 0.28; 95{\%} CI, 0.12-0.60 and 0.37; 95{\%} CI, 0.10-1.28 among men and 0.39; 95{\%} CI, 0.26-0.57 and 0.96; 95{\%} CI, 0.58-1.57 among women, respectively). CONCLUSIONS: These findings provide evidence that high TC prevention efforts must expand the target to not only overweight but also to normal and underweight people.",
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T2 - NIPPON DATA 80, 90, and 2010

AU - Shibata, Yosuke

AU - Ojima, Toshiyuki

AU - Nakamura, Mieko

AU - Kuwabara, Kazuyo

AU - Miyagawa, Naoko

AU - Saito, Yoshino

AU - Nakamura, Yasuyuki

AU - Kiyohara, Yutaka

AU - Nakagawa, Hideaki

AU - Fujiyoshi, Akira

AU - Kadota, Aya

AU - Ohkubo, Takayoshi

AU - Okamura, Tomonori

AU - Ueshima, Hirotsugu

AU - Okayama, Akira

AU - Miura, Katsuyuki

PY - 2019/4/5

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N2 - BACKGROUND: The trend of association between overweight and high serum total cholesterol (TC) among the elderly is unclear. In addition, there is little evidence of risk of underweight for high TC. Therefore, we examined the trend of association of overweight or underweight with high TC among Japanese elderly people using nationwide population-based data. METHODS: Data of the National Survey on Circulatory Disorders and National Health and Nutrition Survey for 1980, 1990, 2000, and 2010 were used in the analysis. High TC was defined as 220 mg/dL and above. For participants aged ≥50 years, sex-specific odds ratios (ORs) of overweight or underweight compared with normal body mass index participants for high TC were calculated using a logistic regression model adjusted for age, smoking, drinking, exercise, food, and treatment of hyperlipidemia. RESULTS: A total of 5,734, 4,673, 5,059, and 2,105 participants enrolled in these surveys in 1980, 1990, 2000, and 2010, respectively. Although overweight was positively and significantly associated with high TC in 1980, the association has gradually weakened since (ORs in 1980 and 2010 were 2.44; 95% confidence interval [CI], 1.83-3.24 and 0.92; 95% CI, 0.66-1.27 among men and 1.43; 95% CI, 1.18-1.72 and 1.08; 95% CI, 0.81-1.44 among women, respectively). While underweight was inversely and significantly associated with high TC in 1980, the association also gradually weakened among women (ORs in 1980 and 2010 were 0.28; 95% CI, 0.12-0.60 and 0.37; 95% CI, 0.10-1.28 among men and 0.39; 95% CI, 0.26-0.57 and 0.96; 95% CI, 0.58-1.57 among women, respectively). CONCLUSIONS: These findings provide evidence that high TC prevention efforts must expand the target to not only overweight but also to normal and underweight people.

AB - BACKGROUND: The trend of association between overweight and high serum total cholesterol (TC) among the elderly is unclear. In addition, there is little evidence of risk of underweight for high TC. Therefore, we examined the trend of association of overweight or underweight with high TC among Japanese elderly people using nationwide population-based data. METHODS: Data of the National Survey on Circulatory Disorders and National Health and Nutrition Survey for 1980, 1990, 2000, and 2010 were used in the analysis. High TC was defined as 220 mg/dL and above. For participants aged ≥50 years, sex-specific odds ratios (ORs) of overweight or underweight compared with normal body mass index participants for high TC were calculated using a logistic regression model adjusted for age, smoking, drinking, exercise, food, and treatment of hyperlipidemia. RESULTS: A total of 5,734, 4,673, 5,059, and 2,105 participants enrolled in these surveys in 1980, 1990, 2000, and 2010, respectively. Although overweight was positively and significantly associated with high TC in 1980, the association has gradually weakened since (ORs in 1980 and 2010 were 2.44; 95% confidence interval [CI], 1.83-3.24 and 0.92; 95% CI, 0.66-1.27 among men and 1.43; 95% CI, 1.18-1.72 and 1.08; 95% CI, 0.81-1.44 among women, respectively). While underweight was inversely and significantly associated with high TC in 1980, the association also gradually weakened among women (ORs in 1980 and 2010 were 0.28; 95% CI, 0.12-0.60 and 0.37; 95% CI, 0.10-1.28 among men and 0.39; 95% CI, 0.26-0.57 and 0.96; 95% CI, 0.58-1.57 among women, respectively). CONCLUSIONS: These findings provide evidence that high TC prevention efforts must expand the target to not only overweight but also to normal and underweight people.

KW - body mass index

KW - hyperlipidemias

KW - Japan

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KW - thinness

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