Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis

Koji Yamanaka, Seung Joo Chun, Severine Boillee, Noriko Fujimori-Tonou, Hirofumi Yamashita, David H. Gutmann, Ryosuke Takahashi, Hidemi Misawa, Don W. Cleveland

Research output: Contribution to journalArticle

704 Citations (Scopus)

Abstract

Dominant mutations in superoxide dismutase cause amyotrophic lateral sclerosis (ALS), an adult-onset neurodegenerative disease that is characterized by the loss of motor neurons. Using mice carrying a deletable mutant gene, diminished mutant expression in astrocytes did not affect onset, but delayed microglial activation and sharply slowed later disease progression. These findings demonstrate that mutant astrocytes are viable targets for therapies for slowing the progression of non-cell autonomous killing of motor neurons in ALS.

Original languageEnglish
Pages (from-to)251-253
Number of pages3
JournalNature Neuroscience
Volume11
Issue number3
DOIs
Publication statusPublished - 2008 Mar

Fingerprint

Amyotrophic Lateral Sclerosis
Motor Neurons
Astrocytes
Disease Progression
Neurodegenerative Diseases
Superoxide Dismutase
Mutation
Genes
Therapeutics

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Yamanaka, K., Chun, S. J., Boillee, S., Fujimori-Tonou, N., Yamashita, H., Gutmann, D. H., ... Cleveland, D. W. (2008). Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis. Nature Neuroscience, 11(3), 251-253. https://doi.org/10.1038/nn2047

Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis. / Yamanaka, Koji; Chun, Seung Joo; Boillee, Severine; Fujimori-Tonou, Noriko; Yamashita, Hirofumi; Gutmann, David H.; Takahashi, Ryosuke; Misawa, Hidemi; Cleveland, Don W.

In: Nature Neuroscience, Vol. 11, No. 3, 03.2008, p. 251-253.

Research output: Contribution to journalArticle

Yamanaka, K, Chun, SJ, Boillee, S, Fujimori-Tonou, N, Yamashita, H, Gutmann, DH, Takahashi, R, Misawa, H & Cleveland, DW 2008, 'Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis', Nature Neuroscience, vol. 11, no. 3, pp. 251-253. https://doi.org/10.1038/nn2047
Yamanaka K, Chun SJ, Boillee S, Fujimori-Tonou N, Yamashita H, Gutmann DH et al. Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis. Nature Neuroscience. 2008 Mar;11(3):251-253. https://doi.org/10.1038/nn2047
Yamanaka, Koji ; Chun, Seung Joo ; Boillee, Severine ; Fujimori-Tonou, Noriko ; Yamashita, Hirofumi ; Gutmann, David H. ; Takahashi, Ryosuke ; Misawa, Hidemi ; Cleveland, Don W. / Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis. In: Nature Neuroscience. 2008 ; Vol. 11, No. 3. pp. 251-253.
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