Asymmetric catalysis via dynamic substrate/ligand/rare earth metal conglomerate

Akihiro Nojiri, Naoya Kumagai, Masakatsu Shibasaki

Research output: Contribution to journalArticlepeer-review

52 Citations (Scopus)

Abstract

A highly enantio- and diastereoselective catalytic asymmetric Mannich-type reaction of α-cyanoketones and N-Boc imines promoted by an amide ligand/Sc(OiPr)3 catalyst is described. The similar reaction outcome is obtained with/without precomplexation of catalyst, suggesting that reaction components in a non-ordered conglomerate mixture orchestrate to form an ordered transition state during the reaction. Spectroscopic data and Eyring plot are consistent with this assumption.

Original languageEnglish
Pages (from-to)5630-5631
Number of pages2
JournalJournal of the American Chemical Society
Volume130
Issue number17
DOIs
Publication statusPublished - 2008 Apr 30
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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