A highly enantio- and diastereoselective catalytic asymmetric Mannich-type reaction of α-cyanoketones and N-Boc imines promoted by an amide ligand/Sc(OiPr)3 catalyst is described. The similar reaction outcome is obtained with/without precomplexation of catalyst, suggesting that reaction components in a non-ordered conglomerate mixture orchestrate to form an ordered transition state during the reaction. Spectroscopic data and Eyring plot are consistent with this assumption.
ASJC Scopus subject areas
- Colloid and Surface Chemistry