Asymmetric catalysis with bis(hydroxyphenyl)diamides/rare-earth metal complexes

Naoya Kumagai, Masakatsu Shibasaki

Research output: Contribution to journalReview articlepeer-review

55 Citations (Scopus)

Abstract

A series of asymmetric catalysts composed of conformationally flexible amide-based chiral ligands and rare-earth metals was developed for proton-transfer catalysis. These ligands derived from amino acids provide an intriguing chiral platform for the formation of asymmetric catalysts upon complexation with rare-earth metals. The scope of this arsenal of catalysts was further broadened by the development of heterobimetallic catalytic systems. The cooperative function of hydrogen bonding and metal coordination resulted in intriguing substrate specificity and stereocontrol, and the dynamic nature of the catalysts led to a switch of their function. Herein, we summarize our recent exploration of this class of catalysts.

Original languageEnglish
Pages (from-to)223-234
Number of pages12
JournalAngewandte Chemie - International Edition
Volume52
Issue number1
DOIs
Publication statusPublished - 2013 Jan 2
Externally publishedYes

Keywords

  • Amides
  • Asymmetric catalysis
  • Atom economy
  • Heterobimetallic
  • Rare earths

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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