Asymmetric decarboxylation of disubstituted malonic acid by alcaligenes bronchisepticus KU 1201

Kenji Miyamoto, Hiromichi Ohta

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Optically active αarylpropionic acids constitute a group which involves many useful compounds. We selected a microorganism which has the ability to realize the asymmetric decarboxylation of αmethyl-αphenylmalonic acid to afford optically active αphenylpropionic acid and it identified as Alcaligenes bronchisepticus KU 1201. When the aryl group was phenyl, 4-chlorophenyl, 6-methoxy-2-naphthyl or 2-thienyl, the substrate afforded optically active αarylpropionic acid in high optical and chemical yield.

Original languageEnglish
Pages (from-to)49-60
Number of pages12
JournalBiocatalysis and Biotransformation
Volume5
Issue number1
DOIs
Publication statusPublished - 1991 Jan 1

Keywords

  • Alcaligenes bronchisepticus.
  • Asymmetric decarboxylation
  • Disubstituted malonic acid
  • αarylpropionic acid

ASJC Scopus subject areas

  • Biotechnology
  • Catalysis
  • Biochemistry

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