Asymmetric hydrolysis of a disubstituted malononitrile by the aid of a microorganism

Masahiro Yokoyama, Takeshi Sugai, Hiromichi Ohta

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Rhodococcus rhodochrous ATCC 21197 hydrolyzed prochiral butylmethylmalononitrile to afford the corresponding amide-carboxylic acid with high enantiomeric excess. The reaction proceeds via the hydration of the starting dinitrile by a nitrile hydratase and the subsequent enantioselective hydrolysis of the intermediate diamide by an amidase.

Original languageEnglish
Pages (from-to)1081-1084
Number of pages4
JournalTetrahedron: Asymmetry
Volume4
Issue number6
DOIs
Publication statusPublished - 1993

Fingerprint

amidase
Diamide
malononitrile
Rhodococcus
nitriles
microorganisms
Carboxylic Acids
Carboxylic acids
Amides
carboxylic acids
Hydration
Microorganisms
amides
hydration
hydrolysis
Hydrolysis
nitrile hydratase
dicyanmethane

ASJC Scopus subject areas

  • Inorganic Chemistry
  • Organic Chemistry
  • Materials Chemistry
  • Drug Discovery

Cite this

Asymmetric hydrolysis of a disubstituted malononitrile by the aid of a microorganism. / Yokoyama, Masahiro; Sugai, Takeshi; Ohta, Hiromichi.

In: Tetrahedron: Asymmetry, Vol. 4, No. 6, 1993, p. 1081-1084.

Research output: Contribution to journalArticle

Yokoyama, Masahiro ; Sugai, Takeshi ; Ohta, Hiromichi. / Asymmetric hydrolysis of a disubstituted malononitrile by the aid of a microorganism. In: Tetrahedron: Asymmetry. 1993 ; Vol. 4, No. 6. pp. 1081-1084.
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