Asymmetric hydrolysis of l-Cyanoalkyl acetates

Hiromichi Ohta, Satoshi Hiraga, Kenji Miyamoto, Gen Ichi Tsuchihashi

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Abstract

Microorganisms that enantioselectively hydrolyze I-cyanoalkyl acetates (aldehyde cyanohydrin) were screened. Candida tropicalis was found to be the best. The enzyme system of this strain catalyzed the enantioselective hydrolysis of (S)-isomers, leaving behind the (R)-acetates. The optical purities of recovered acetates were high as measured by IH-NMR analysis in the presence of a chiral shift reagent.

Original languageEnglish
Pages (from-to)3023-3027
Number of pages5
JournalAgricultural and biological chemistry
Volume52
Issue number12
DOIs
Publication statusPublished - 1988 Dec

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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