Asymmetric hydrolysis of l-Cyanoalkyl acetates

Hiromichi Ohta, Satoshi Hiraga, Kenji Miyamoto, Gen Ichi Tsuchihashi

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Microorganisms that enantioselectively hydrolyze I-cyanoalkyl acetates (aldehyde cyanohydrin) were screened. Candida tropicalis was found to be the best. The enzyme system of this strain catalyzed the enantioselective hydrolysis of (S)-isomers, leaving behind the (R)-acetates. The optical purities of recovered acetates were high as measured by IH-NMR analysis in the presence of a chiral shift reagent.

Original languageEnglish
Pages (from-to)3023-3027
Number of pages5
JournalAgricultural and Biological Chemistry
Volume52
Issue number12
DOIs
Publication statusPublished - 1988

Fingerprint

Hydrolysis
Acetates
hydrolysis
acetates
Candida tropicalis
Candida
Aldehydes
Isomers
purity
Microorganisms
aldehydes
isomers
Nuclear magnetic resonance
microorganisms
Enzymes
enzymes
cyanohydrin

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Asymmetric hydrolysis of l-Cyanoalkyl acetates. / Ohta, Hiromichi; Hiraga, Satoshi; Miyamoto, Kenji; Tsuchihashi, Gen Ichi.

In: Agricultural and Biological Chemistry, Vol. 52, No. 12, 1988, p. 3023-3027.

Research output: Contribution to journalArticle

Ohta, Hiromichi ; Hiraga, Satoshi ; Miyamoto, Kenji ; Tsuchihashi, Gen Ichi. / Asymmetric hydrolysis of l-Cyanoalkyl acetates. In: Agricultural and Biological Chemistry. 1988 ; Vol. 52, No. 12. pp. 3023-3027.
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