Asymmetric inheritance of radial glial fibers by cortical neurons

Takaki Miyata, Ayano Kawaguchi, Hideyuki Okano, Masaharu Ogawa

Research output: Contribution to journalArticle

639 Citations (Scopus)

Abstract

Recent studies demonstrated the neuronogenic role of radial glial cells (RGCs) in the rodent. To reveal the fate of radial glial processes, we intensively monitored divisions of RGCs in DiI-labeled slices from the embryonic day 14 mouse cortex. During RGC division, each pia-connected fiber becomes thin but is neither lost nor divided; it is inherited asymmetrically by one daughter cell. In divisions that produce a neuron and a progenitor, the neuron inherits the pial fiber, also grows a thick ventricular process for several hours, and is therefore indistinguishable from the progenitor RGC. The ventricular process in the radial glial-like neuron ("radial neuron") then collapses, leading to ascent of the neuron by using the "recycled" radial fiber.

Original languageEnglish
Pages (from-to)727-741
Number of pages15
JournalNeuron
Volume31
Issue number5
DOIs
Publication statusPublished - 2001 Sep 13

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Ependymoglial Cells
Neuroglia
Neurons
Cell Division
Rodentia

ASJC Scopus subject areas

  • Neuroscience(all)

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Asymmetric inheritance of radial glial fibers by cortical neurons. / Miyata, Takaki; Kawaguchi, Ayano; Okano, Hideyuki; Ogawa, Masaharu.

In: Neuron, Vol. 31, No. 5, 13.09.2001, p. 727-741.

Research output: Contribution to journalArticle

Miyata, Takaki ; Kawaguchi, Ayano ; Okano, Hideyuki ; Ogawa, Masaharu. / Asymmetric inheritance of radial glial fibers by cortical neurons. In: Neuron. 2001 ; Vol. 31, No. 5. pp. 727-741.
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