Asymmetric random walk in a reaction intermediate of homologous recombination

Youhei Fujitani, Ichizo Kobayashi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

At an intermediate step of the homologous recombination between two double-stranded DNA molecules, a point (often called Holliday structure) connecting two strands coming from two recombining partners migrates along the homologous region. Assuming random walk of a connecting point, we previously explained the dependence of recombination frequency on the homology length observed in vivo. In this model, the random walk was assumed to be symmetric in that the forward transition rate equals the backward one. According to observations in vitro, however, catalysed migration appears unidirectional. Taking into account possible asymmetry, we thus reformulate our random walk model to reexamine the observations in vivo. We also derive some theoretical results to analyse dynamic processes observed in vitro.

Original languageEnglish
Pages (from-to)359-370
Number of pages12
JournalJournal of Theoretical Biology
Volume220
Issue number3
DOIs
Publication statusPublished - 2003

Fingerprint

Reaction intermediates
Homologous Recombination
homologous recombination
Recombination
Random walk
Genetic Recombination
DNA
Dynamic Process
Molecules
Asymmetry
Migration
Homology
Model
In Vitro Techniques
Observation

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

Asymmetric random walk in a reaction intermediate of homologous recombination. / Fujitani, Youhei; Kobayashi, Ichizo.

In: Journal of Theoretical Biology, Vol. 220, No. 3, 2003, p. 359-370.

Research output: Contribution to journalArticle

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