TY - JOUR
T1 - Asymmetric random walk in a reaction intermediate of homologous recombination
AU - Fujitani, Youhei
AU - Kobayashi, Ichizo
N1 - Funding Information:
Kyoichi Saito checked our calculations in completing his master thesis (Keio University, 2000). The work by Y.F. was partly financed by Keio Gakuji Shinko Shikin. The work by I.K. was supported by the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of the Japanese government (Genome biology, Genome homeostasis) and Uehara Memorial Foundation.
PY - 2003
Y1 - 2003
N2 - At an intermediate step of the homologous recombination between two double-stranded DNA molecules, a point (often called Holliday structure) connecting two strands coming from two recombining partners migrates along the homologous region. Assuming random walk of a connecting point, we previously explained the dependence of recombination frequency on the homology length observed in vivo. In this model, the random walk was assumed to be symmetric in that the forward transition rate equals the backward one. According to observations in vitro, however, catalysed migration appears unidirectional. Taking into account possible asymmetry, we thus reformulate our random walk model to reexamine the observations in vivo. We also derive some theoretical results to analyse dynamic processes observed in vitro.
AB - At an intermediate step of the homologous recombination between two double-stranded DNA molecules, a point (often called Holliday structure) connecting two strands coming from two recombining partners migrates along the homologous region. Assuming random walk of a connecting point, we previously explained the dependence of recombination frequency on the homology length observed in vivo. In this model, the random walk was assumed to be symmetric in that the forward transition rate equals the backward one. According to observations in vitro, however, catalysed migration appears unidirectional. Taking into account possible asymmetry, we thus reformulate our random walk model to reexamine the observations in vivo. We also derive some theoretical results to analyse dynamic processes observed in vitro.
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U2 - 10.1006/jtbi.2003.3167
DO - 10.1006/jtbi.2003.3167
M3 - Article
C2 - 12468285
AN - SCOPUS:0037271617
VL - 220
SP - 359
EP - 370
JO - Journal of Theoretical Biology
JF - Journal of Theoretical Biology
SN - 0022-5193
IS - 3
ER -