Abstract
At an intermediate step of the homologous recombination between two double-stranded DNA molecules, a point (often called Holliday structure) connecting two strands coming from two recombining partners migrates along the homologous region. Assuming random walk of a connecting point, we previously explained the dependence of recombination frequency on the homology length observed in vivo. In this model, the random walk was assumed to be symmetric in that the forward transition rate equals the backward one. According to observations in vitro, however, catalysed migration appears unidirectional. Taking into account possible asymmetry, we thus reformulate our random walk model to reexamine the observations in vivo. We also derive some theoretical results to analyse dynamic processes observed in vitro.
| Original language | English |
|---|---|
| Pages (from-to) | 359-370 |
| Number of pages | 12 |
| Journal | Journal of Theoretical Biology |
| Volume | 220 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2003 |
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ASJC Scopus subject areas
- Agricultural and Biological Sciences(all)
Cite this
Asymmetric random walk in a reaction intermediate of homologous recombination. / Fujitani, Youhei; Kobayashi, Ichizo.
In: Journal of Theoretical Biology, Vol. 220, No. 3, 2003, p. 359-370.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Asymmetric random walk in a reaction intermediate of homologous recombination
AU - Fujitani, Youhei
AU - Kobayashi, Ichizo
PY - 2003
Y1 - 2003
N2 - At an intermediate step of the homologous recombination between two double-stranded DNA molecules, a point (often called Holliday structure) connecting two strands coming from two recombining partners migrates along the homologous region. Assuming random walk of a connecting point, we previously explained the dependence of recombination frequency on the homology length observed in vivo. In this model, the random walk was assumed to be symmetric in that the forward transition rate equals the backward one. According to observations in vitro, however, catalysed migration appears unidirectional. Taking into account possible asymmetry, we thus reformulate our random walk model to reexamine the observations in vivo. We also derive some theoretical results to analyse dynamic processes observed in vitro.
AB - At an intermediate step of the homologous recombination between two double-stranded DNA molecules, a point (often called Holliday structure) connecting two strands coming from two recombining partners migrates along the homologous region. Assuming random walk of a connecting point, we previously explained the dependence of recombination frequency on the homology length observed in vivo. In this model, the random walk was assumed to be symmetric in that the forward transition rate equals the backward one. According to observations in vitro, however, catalysed migration appears unidirectional. Taking into account possible asymmetry, we thus reformulate our random walk model to reexamine the observations in vivo. We also derive some theoretical results to analyse dynamic processes observed in vitro.
UR - http://www.scopus.com/inward/record.url?scp=0037271617&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037271617&partnerID=8YFLogxK
U2 - 10.1006/jtbi.2003.3167
DO - 10.1006/jtbi.2003.3167
M3 - Article
C2 - 12468285
AN - SCOPUS:0037271617
VL - 220
SP - 359
EP - 370
JO - Journal of Theoretical Biology
JF - Journal of Theoretical Biology
SN - 0022-5193
IS - 3
ER -