Asymmetric synthesis of aerothionin, a marine dimeric spiroisoxazoline natural product, employing optically active spiroisoxazoline derivative

Takahisa Ogamino, Rika Obata, Shigeru Nishiyama

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Successful first synthesis of optically pure (+)- and (-)-aerothionins (1) from the racemic spiroisoxazoline derivative 8 has been accomplished. The absolute configuration of natural (+)-1 was determined by comparison of (+)- and (-)-8 with related derivatives.

Original languageEnglish
Pages (from-to)727-731
Number of pages5
JournalTetrahedron Letters
Volume47
Issue number5
DOIs
Publication statusPublished - 2006 Jan 30

Keywords

  • Aerothionin
  • Bromotyrosine
  • Diastereomeric separation
  • Spiroisoxazoline

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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