Asymmetric synthesis of aerothionin, a marine dimeric spiroisoxazoline natural product, employing optically active spiroisoxazoline derivative

Takahisa Ogamino, Rika Obata, Shigeru Nishiyama

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Successful first synthesis of optically pure (+)- and (-)-aerothionins (1) from the racemic spiroisoxazoline derivative 8 has been accomplished. The absolute configuration of natural (+)-1 was determined by comparison of (+)- and (-)-8 with related derivatives.

Original languageEnglish
Pages (from-to)727-731
Number of pages5
JournalTetrahedron Letters
Volume47
Issue number5
DOIs
Publication statusPublished - 2006 Jan 30

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Biological Products
Derivatives
aerothionin

Keywords

  • Aerothionin
  • Bromotyrosine
  • Diastereomeric separation
  • Spiroisoxazoline

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Asymmetric synthesis of aerothionin, a marine dimeric spiroisoxazoline natural product, employing optically active spiroisoxazoline derivative. / Ogamino, Takahisa; Obata, Rika; Nishiyama, Shigeru.

In: Tetrahedron Letters, Vol. 47, No. 5, 30.01.2006, p. 727-731.

Research output: Contribution to journalArticle

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