It has been established that cationic rhodium(I)/axially chiral biaryl bis(phosphine) complexes catalyze the asymmetric [2+2+2] cycloaddition of 1,6-enynes with electron-rich functionalized alkenes, enamides, and vinyl carboxylates, to produce the corresponding protected cyclohexenylamines and cyclohexenols. Interestingly, regioselectivity depends on structures of substrates. The present cycloaddition was successfully applied to the enantioselective total synthesis of (−)-porosadienone by using the amide moiety as a leaving group.
|Number of pages||4|
|Journal||Angewandte Chemie - International Edition|
|Publication status||Published - 2016 Dec 5|
- asymmetric catalysis
- reaction mechanisms
ASJC Scopus subject areas