ATF7IP as a novel PDGFRB fusion partner in acute lymphoblastic leukaemia in children

Kenichiro Kobayashi; Kazumasa Mitsui; Hitoshi Ichikawa; Kazuhiko Nakabayashi; Masaki Matsuoka; Yasuko Kojima; Hiroyuki Takahashi; Kazutoshi Iijima; Kaori Ootsubo; Keisuke Oboki; Hajime Okita; Kazuki Yasuda; Hiromi Sakamoto; Kenichiro Hata; Teruhiko Yoshida; Kenji Matsumoto; Nobutaka Kiyokawa; Akira Ohara

doi:10.1111/bjh.12834

ATF7IP as a novel PDGFRB fusion partner in acute lymphoblastic leukaemia in children

Kenichiro Kobayashi, Kazumasa Mitsui, Hitoshi Ichikawa, Kazuhiko Nakabayashi, Masaki Matsuoka, Yasuko Kojima, Hiroyuki Takahashi, Kazutoshi Iijima, Kaori Ootsubo, Keisuke Oboki, Hajime Okita, Kazuki Yasuda, Hiromi Sakamoto, Kenichiro Hata, Teruhiko Yoshida, Kenji Matsumoto, Nobutaka Kiyokawa, Akira Ohara

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

We identified ATF7IP as a novel PDGFRB fusion partner in B-progenitor acute lymphoblastic leukaemia (B-ALL) and showed that B-ALL with ATF7IP/PDGFRB translocation is included within the genomic lesions of a Philadelphia chromosome (Ph)-like ALL subgroup. Comprehensive analyses of previous repositories of gene expression data sets disclosed that B-ALL cases with high PDGFRB expression level in the context of the Ph-like ALL gene are likely to have a PDGFRB translocation. Thus, it is possible that measurement of the PDGFRB expression level can be utilized as a screening test for the detection of the cryptic PDGFRB translocation, especially within the Ph-like ALL subgroup.

Original language	English
Pages (from-to)	836-841
Number of pages	6
Journal	British Journal of Haematology
Volume	165
Issue number	6
DOIs	https://doi.org/10.1111/bjh.12834
Publication status	Published - 2014 Jun
Externally published	Yes

Keywords

ATF7IP
Acute lymphoblastic leukaemia
PDGFRB
Ph-like
Screening

ASJC Scopus subject areas

Hematology

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10.1111/bjh.12834

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Kobayashi, K., Mitsui, K., Ichikawa, H., Nakabayashi, K., Matsuoka, M., Kojima, Y., Takahashi, H., Iijima, K., Ootsubo, K., Oboki, K., Okita, H., Yasuda, K., Sakamoto, H., Hata, K., Yoshida, T., Matsumoto, K., Kiyokawa, N., & Ohara, A. (2014). ATF7IP as a novel PDGFRB fusion partner in acute lymphoblastic leukaemia in children. British Journal of Haematology, 165(6), 836-841. https://doi.org/10.1111/bjh.12834

Kobayashi, K, Mitsui, K, Ichikawa, H, Nakabayashi, K, Matsuoka, M, Kojima, Y, Takahashi, H, Iijima, K, Ootsubo, K, Oboki, K, Okita, H, Yasuda, K, Sakamoto, H, Hata, K, Yoshida, T, Matsumoto, K, Kiyokawa, N & Ohara, A 2014, 'ATF7IP as a novel PDGFRB fusion partner in acute lymphoblastic leukaemia in children', British Journal of Haematology, vol. 165, no. 6, pp. 836-841. https://doi.org/10.1111/bjh.12834

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title = "ATF7IP as a novel PDGFRB fusion partner in acute lymphoblastic leukaemia in children",

abstract = "We identified ATF7IP as a novel PDGFRB fusion partner in B-progenitor acute lymphoblastic leukaemia (B-ALL) and showed that B-ALL with ATF7IP/PDGFRB translocation is included within the genomic lesions of a Philadelphia chromosome (Ph)-like ALL subgroup. Comprehensive analyses of previous repositories of gene expression data sets disclosed that B-ALL cases with high PDGFRB expression level in the context of the Ph-like ALL gene are likely to have a PDGFRB translocation. Thus, it is possible that measurement of the PDGFRB expression level can be utilized as a screening test for the detection of the cryptic PDGFRB translocation, especially within the Ph-like ALL subgroup.",

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author = "Kenichiro Kobayashi and Kazumasa Mitsui and Hitoshi Ichikawa and Kazuhiko Nakabayashi and Masaki Matsuoka and Yasuko Kojima and Hiroyuki Takahashi and Kazutoshi Iijima and Kaori Ootsubo and Keisuke Oboki and Hajime Okita and Kazuki Yasuda and Hiromi Sakamoto and Kenichiro Hata and Teruhiko Yoshida and Kenji Matsumoto and Nobutaka Kiyokawa and Akira Ohara",

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doi = "10.1111/bjh.12834",

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AU - Kobayashi, Kenichiro

AU - Mitsui, Kazumasa

AU - Ichikawa, Hitoshi

AU - Nakabayashi, Kazuhiko

AU - Matsuoka, Masaki

AU - Kojima, Yasuko

AU - Takahashi, Hiroyuki

AU - Iijima, Kazutoshi

AU - Ootsubo, Kaori

AU - Oboki, Keisuke

AU - Okita, Hajime

AU - Yasuda, Kazuki

AU - Sakamoto, Hiromi

AU - Hata, Kenichiro

AU - Yoshida, Teruhiko

AU - Matsumoto, Kenji

AU - Kiyokawa, Nobutaka

AU - Ohara, Akira

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AB - We identified ATF7IP as a novel PDGFRB fusion partner in B-progenitor acute lymphoblastic leukaemia (B-ALL) and showed that B-ALL with ATF7IP/PDGFRB translocation is included within the genomic lesions of a Philadelphia chromosome (Ph)-like ALL subgroup. Comprehensive analyses of previous repositories of gene expression data sets disclosed that B-ALL cases with high PDGFRB expression level in the context of the Ph-like ALL gene are likely to have a PDGFRB translocation. Thus, it is possible that measurement of the PDGFRB expression level can be utilized as a screening test for the detection of the cryptic PDGFRB translocation, especially within the Ph-like ALL subgroup.

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KW - Acute lymphoblastic leukaemia

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ATF7IP as a novel PDGFRB fusion partner in acute lymphoblastic leukaemia in children

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