ATF7IP as a novel PDGFRB fusion partner in acute lymphoblastic leukaemia in children

Kenichiro Kobayashi, Kazumasa Mitsui, Hitoshi Ichikawa, Kazuhiko Nakabayashi, Masaki Matsuoka, Yasuko Kojima, Hiroyuki Takahashi, Kazutoshi Iijima, Kaori Ootsubo, Keisuke Oboki, Hajime Okita, Kazuki Yasuda, Hiromi Sakamoto, Kenichiro Hata, Teruhiko Yoshida, Kenji Matsumoto, Nobutaka Kiyokawa, Akira Ohara

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

We identified ATF7IP as a novel PDGFRB fusion partner in B-progenitor acute lymphoblastic leukaemia (B-ALL) and showed that B-ALL with ATF7IP/PDGFRB translocation is included within the genomic lesions of a Philadelphia chromosome (Ph)-like ALL subgroup. Comprehensive analyses of previous repositories of gene expression data sets disclosed that B-ALL cases with high PDGFRB expression level in the context of the Ph-like ALL gene are likely to have a PDGFRB translocation. Thus, it is possible that measurement of the PDGFRB expression level can be utilized as a screening test for the detection of the cryptic PDGFRB translocation, especially within the Ph-like ALL subgroup.

Original languageEnglish
Pages (from-to)836-841
Number of pages6
JournalBritish Journal of Haematology
Volume165
Issue number6
DOIs
Publication statusPublished - 2014 Jun
Externally publishedYes

Keywords

  • ATF7IP
  • Acute lymphoblastic leukaemia
  • PDGFRB
  • Ph-like
  • Screening

ASJC Scopus subject areas

  • Hematology

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  • Cite this

    Kobayashi, K., Mitsui, K., Ichikawa, H., Nakabayashi, K., Matsuoka, M., Kojima, Y., Takahashi, H., Iijima, K., Ootsubo, K., Oboki, K., Okita, H., Yasuda, K., Sakamoto, H., Hata, K., Yoshida, T., Matsumoto, K., Kiyokawa, N., & Ohara, A. (2014). ATF7IP as a novel PDGFRB fusion partner in acute lymphoblastic leukaemia in children. British Journal of Haematology, 165(6), 836-841. https://doi.org/10.1111/bjh.12834