Atlas of the developing brain of the marmoset monkey constructed using magnetic resonance histology

K. Hikishima, K. Sawada, A. Y. Murayama, Y. Komaki, K. Kawai, N. Sato, T. Inoue, T. Itoh, Suketaka Momoshima, A. Iriki, H. J. Okano, E. Sasaki, Hideyuki Okano

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The developmental anatomy of the brain is largely directed by neural-based cues. Despite this knowledge, the developmental trajectory of the primate brain has not yet been fully characterized. To realize this goal, the advance in noninvasive imaging methods and new brain atlases are essential. The common marmoset (Callithrix jacchus), a small New World primate, is widely used in neuroscience research. The recent introduction of transgenic techniques has enabled the marmoset to be used as a genetically modifiable primate model for brain development. Here, a magnetic resonance histology technique involving the use of ultra-high-resolution ex vivo magnetic resonance imaging (MRI) was performed to identify the developmental anatomy of the marmoset brain at different time points from gestational week 8 through to birth. The data allowed the generation of a multidimensional atlas of brain structures at different developmental stages. Furthermore, in utero MRI techniques were developed to noninvasively monitor brain development during the embryonic and fetal stages. The multidimensional atlas and the MRI tools developed herein are anticipated to further our understanding of the developing primate brain.

Original languageEnglish
Pages (from-to)102-113
Number of pages12
JournalNeuroscience
Volume230
DOIs
Publication statusPublished - 2013 Jan 29

Fingerprint

Callithrix
Atlases
Haplorhini
Histology
Magnetic Resonance Spectroscopy
Brain
Primates
Magnetic Resonance Imaging
Anatomy
Embryonic and Fetal Development
Neurosciences
Cues
Parturition

Keywords

  • Atlas
  • Callithrix jacchus
  • Common marmoset
  • In utero
  • Magnetic resonance histology
  • Non-human primate

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Atlas of the developing brain of the marmoset monkey constructed using magnetic resonance histology. / Hikishima, K.; Sawada, K.; Murayama, A. Y.; Komaki, Y.; Kawai, K.; Sato, N.; Inoue, T.; Itoh, T.; Momoshima, Suketaka; Iriki, A.; Okano, H. J.; Sasaki, E.; Okano, Hideyuki.

In: Neuroscience, Vol. 230, 29.01.2013, p. 102-113.

Research output: Contribution to journalArticle

Hikishima, K, Sawada, K, Murayama, AY, Komaki, Y, Kawai, K, Sato, N, Inoue, T, Itoh, T, Momoshima, S, Iriki, A, Okano, HJ, Sasaki, E & Okano, H 2013, 'Atlas of the developing brain of the marmoset monkey constructed using magnetic resonance histology', Neuroscience, vol. 230, pp. 102-113. https://doi.org/10.1016/j.neuroscience.2012.09.053
Hikishima, K. ; Sawada, K. ; Murayama, A. Y. ; Komaki, Y. ; Kawai, K. ; Sato, N. ; Inoue, T. ; Itoh, T. ; Momoshima, Suketaka ; Iriki, A. ; Okano, H. J. ; Sasaki, E. ; Okano, Hideyuki. / Atlas of the developing brain of the marmoset monkey constructed using magnetic resonance histology. In: Neuroscience. 2013 ; Vol. 230. pp. 102-113.
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