Atrial and brain natriuretic peptides in cardiovascular diseases

Mitsuhide Naruse, Youichi Takeyama, Akiyo Tanabe, Juichi Hiroshige, Kiyoko Naruse, Takanobu Yoshimoto, Masami Tanaka, Takashi Katagiri, Hiroshi Demura

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

The human heart secretes both atrial natriuretic peptide and brain natriuretic peptide. This study attempts to clarify the pathophysiological significance of the peptides in cardiovascular diseases. Using immunoradiometric assay, plasma brain natriuretic peptide and atrial natriuretic peptide levels in essential hypertension, various secondary hypertension, chronic renal failure, chronic heart failure during cardiac pacing, and acute myocardial infarction were determined. Mean plasma brain natriuretic peptide and atrial natriuretic peptide levels in healthy subjects were 3.7±0.3 and 5.7±0.3 pmol/L, respectively, and increased as a function of age. Plasma brain natriuretic peptide levels showed a larger increase than atrial natriuretic peptide levels in various cardiovascular diseases. In chronic renal failure, whereas plasma atrial natriuretic peptide levels decreased significantly after hemodiarysis and were correlated with the changes in body weight, changes in plasma brain natriuretic peptide levels were less prominent and did not show such a correlation. In chronic heart failure, both basal plasma brain natriuretic peptide and atrial natriuretic peptide levels were also significantly elevated. However, in response to acute ventricular or atrial pacing, brain natriuretic peptide levels did not show any increase in contrast to the marked increase of atrial natriuretic peptide levels. In acute myocardial infarction, brain natriuretic peptide levels showed more prominent changes than atrial natriuretic peptide levels and were correlated with serum levels of creatine kinase and cardiac myosin light chain I in most patients. These results suggest that both brain and atrial natriuretic peptides play an important role in the regulation of cardiovascular homeostasis. The two natriuretic peptides appear to take partial charge of their respective roles in responding to various hemodynamic overloads to the heart.

Original languageEnglish
Pages (from-to)I-231-I-234
JournalHypertension
Volume23
Issue number1
Publication statusPublished - 1994 Jan
Externally publishedYes

Fingerprint

Brain Natriuretic Peptide
Atrial Natriuretic Factor
Cardiovascular Diseases
Chronic Kidney Failure
Heart Failure
Myocardial Infarction
Cardiac Myosins
Immunoradiometric Assay
Natriuretic Peptides
Body Weight Changes
Creatine Kinase
Healthy Volunteers
Homeostasis
Hemodynamics
Hypertension
Peptides

Keywords

  • Aging
  • Cardiac pacing
  • Heart failure
  • Hypertension, essential
  • Myocardial infarction
  • Natriuretic peptide

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Naruse, M., Takeyama, Y., Tanabe, A., Hiroshige, J., Naruse, K., Yoshimoto, T., ... Demura, H. (1994). Atrial and brain natriuretic peptides in cardiovascular diseases. Hypertension, 23(1), I-231-I-234.

Atrial and brain natriuretic peptides in cardiovascular diseases. / Naruse, Mitsuhide; Takeyama, Youichi; Tanabe, Akiyo; Hiroshige, Juichi; Naruse, Kiyoko; Yoshimoto, Takanobu; Tanaka, Masami; Katagiri, Takashi; Demura, Hiroshi.

In: Hypertension, Vol. 23, No. 1, 01.1994, p. I-231-I-234.

Research output: Contribution to journalArticle

Naruse, M, Takeyama, Y, Tanabe, A, Hiroshige, J, Naruse, K, Yoshimoto, T, Tanaka, M, Katagiri, T & Demura, H 1994, 'Atrial and brain natriuretic peptides in cardiovascular diseases', Hypertension, vol. 23, no. 1, pp. I-231-I-234.
Naruse M, Takeyama Y, Tanabe A, Hiroshige J, Naruse K, Yoshimoto T et al. Atrial and brain natriuretic peptides in cardiovascular diseases. Hypertension. 1994 Jan;23(1):I-231-I-234.
Naruse, Mitsuhide ; Takeyama, Youichi ; Tanabe, Akiyo ; Hiroshige, Juichi ; Naruse, Kiyoko ; Yoshimoto, Takanobu ; Tanaka, Masami ; Katagiri, Takashi ; Demura, Hiroshi. / Atrial and brain natriuretic peptides in cardiovascular diseases. In: Hypertension. 1994 ; Vol. 23, No. 1. pp. I-231-I-234.
@article{b2573cd6deda461ab196f3836f004231,
title = "Atrial and brain natriuretic peptides in cardiovascular diseases",
abstract = "The human heart secretes both atrial natriuretic peptide and brain natriuretic peptide. This study attempts to clarify the pathophysiological significance of the peptides in cardiovascular diseases. Using immunoradiometric assay, plasma brain natriuretic peptide and atrial natriuretic peptide levels in essential hypertension, various secondary hypertension, chronic renal failure, chronic heart failure during cardiac pacing, and acute myocardial infarction were determined. Mean plasma brain natriuretic peptide and atrial natriuretic peptide levels in healthy subjects were 3.7±0.3 and 5.7±0.3 pmol/L, respectively, and increased as a function of age. Plasma brain natriuretic peptide levels showed a larger increase than atrial natriuretic peptide levels in various cardiovascular diseases. In chronic renal failure, whereas plasma atrial natriuretic peptide levels decreased significantly after hemodiarysis and were correlated with the changes in body weight, changes in plasma brain natriuretic peptide levels were less prominent and did not show such a correlation. In chronic heart failure, both basal plasma brain natriuretic peptide and atrial natriuretic peptide levels were also significantly elevated. However, in response to acute ventricular or atrial pacing, brain natriuretic peptide levels did not show any increase in contrast to the marked increase of atrial natriuretic peptide levels. In acute myocardial infarction, brain natriuretic peptide levels showed more prominent changes than atrial natriuretic peptide levels and were correlated with serum levels of creatine kinase and cardiac myosin light chain I in most patients. These results suggest that both brain and atrial natriuretic peptides play an important role in the regulation of cardiovascular homeostasis. The two natriuretic peptides appear to take partial charge of their respective roles in responding to various hemodynamic overloads to the heart.",
keywords = "Aging, Cardiac pacing, Heart failure, Hypertension, essential, Myocardial infarction, Natriuretic peptide",
author = "Mitsuhide Naruse and Youichi Takeyama and Akiyo Tanabe and Juichi Hiroshige and Kiyoko Naruse and Takanobu Yoshimoto and Masami Tanaka and Takashi Katagiri and Hiroshi Demura",
year = "1994",
month = "1",
language = "English",
volume = "23",
pages = "I--231--I--234",
journal = "Hypertension",
issn = "0194-911X",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Atrial and brain natriuretic peptides in cardiovascular diseases

AU - Naruse, Mitsuhide

AU - Takeyama, Youichi

AU - Tanabe, Akiyo

AU - Hiroshige, Juichi

AU - Naruse, Kiyoko

AU - Yoshimoto, Takanobu

AU - Tanaka, Masami

AU - Katagiri, Takashi

AU - Demura, Hiroshi

PY - 1994/1

Y1 - 1994/1

N2 - The human heart secretes both atrial natriuretic peptide and brain natriuretic peptide. This study attempts to clarify the pathophysiological significance of the peptides in cardiovascular diseases. Using immunoradiometric assay, plasma brain natriuretic peptide and atrial natriuretic peptide levels in essential hypertension, various secondary hypertension, chronic renal failure, chronic heart failure during cardiac pacing, and acute myocardial infarction were determined. Mean plasma brain natriuretic peptide and atrial natriuretic peptide levels in healthy subjects were 3.7±0.3 and 5.7±0.3 pmol/L, respectively, and increased as a function of age. Plasma brain natriuretic peptide levels showed a larger increase than atrial natriuretic peptide levels in various cardiovascular diseases. In chronic renal failure, whereas plasma atrial natriuretic peptide levels decreased significantly after hemodiarysis and were correlated with the changes in body weight, changes in plasma brain natriuretic peptide levels were less prominent and did not show such a correlation. In chronic heart failure, both basal plasma brain natriuretic peptide and atrial natriuretic peptide levels were also significantly elevated. However, in response to acute ventricular or atrial pacing, brain natriuretic peptide levels did not show any increase in contrast to the marked increase of atrial natriuretic peptide levels. In acute myocardial infarction, brain natriuretic peptide levels showed more prominent changes than atrial natriuretic peptide levels and were correlated with serum levels of creatine kinase and cardiac myosin light chain I in most patients. These results suggest that both brain and atrial natriuretic peptides play an important role in the regulation of cardiovascular homeostasis. The two natriuretic peptides appear to take partial charge of their respective roles in responding to various hemodynamic overloads to the heart.

AB - The human heart secretes both atrial natriuretic peptide and brain natriuretic peptide. This study attempts to clarify the pathophysiological significance of the peptides in cardiovascular diseases. Using immunoradiometric assay, plasma brain natriuretic peptide and atrial natriuretic peptide levels in essential hypertension, various secondary hypertension, chronic renal failure, chronic heart failure during cardiac pacing, and acute myocardial infarction were determined. Mean plasma brain natriuretic peptide and atrial natriuretic peptide levels in healthy subjects were 3.7±0.3 and 5.7±0.3 pmol/L, respectively, and increased as a function of age. Plasma brain natriuretic peptide levels showed a larger increase than atrial natriuretic peptide levels in various cardiovascular diseases. In chronic renal failure, whereas plasma atrial natriuretic peptide levels decreased significantly after hemodiarysis and were correlated with the changes in body weight, changes in plasma brain natriuretic peptide levels were less prominent and did not show such a correlation. In chronic heart failure, both basal plasma brain natriuretic peptide and atrial natriuretic peptide levels were also significantly elevated. However, in response to acute ventricular or atrial pacing, brain natriuretic peptide levels did not show any increase in contrast to the marked increase of atrial natriuretic peptide levels. In acute myocardial infarction, brain natriuretic peptide levels showed more prominent changes than atrial natriuretic peptide levels and were correlated with serum levels of creatine kinase and cardiac myosin light chain I in most patients. These results suggest that both brain and atrial natriuretic peptides play an important role in the regulation of cardiovascular homeostasis. The two natriuretic peptides appear to take partial charge of their respective roles in responding to various hemodynamic overloads to the heart.

KW - Aging

KW - Cardiac pacing

KW - Heart failure

KW - Hypertension, essential

KW - Myocardial infarction

KW - Natriuretic peptide

UR - http://www.scopus.com/inward/record.url?scp=0027979633&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027979633&partnerID=8YFLogxK

M3 - Article

C2 - 8282365

AN - SCOPUS:0027979633

VL - 23

SP - I-231-I-234

JO - Hypertension

JF - Hypertension

SN - 0194-911X

IS - 1

ER -