Atrial natriuretic peptide secretion in rabbits with aortic regurgitation

Yumiko Wainai, M. Kusuhara, T. Yamada, T. Yoshikawa, M. Suzuki, S. Hori, S. Handa, K. Yoshinaga, K. Yamaguchi

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We investigated whether or not the extent of secretion of atrial natriuretic peptide (ANP) was altered during the chronic course of aortic regurgitation (AR) in rabbits. AR was induced by aortic valve perforation in 20 rabbits. Left ventricular end-diastolic pressure (LVEDP) was used as an index of the severity of heart failure. LVEDP and plasma immunoreactive (IR)-ANP were measured before and at 15 min, 1 week, and 4 weeks after induction of AR. In each period a correlation between LVEDP and plasma IR-ANP was observed, and the coefficients and covariances did not vary throughout the experiment. We conclude, therefore, that a chronic change in ANP secretion does not develop during the first 4 weeks after induction of AR in rabbits.

Original languageEnglish
Pages (from-to)13-18
Number of pages6
JournalResearch in Experimental Medicine
Volume190
Issue number1
DOIs
Publication statusPublished - 1990 Dec

Fingerprint

Aortic Valve Insufficiency
Atrial Natriuretic Factor
Rabbits
Blood Pressure
Aortic Valve
Heart Failure

Keywords

  • Aortic valve insufficiency
  • Heart failure, congestive
  • Natriuretic peptides, atrial
  • Rabbits

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Wainai, Y., Kusuhara, M., Yamada, T., Yoshikawa, T., Suzuki, M., Hori, S., ... Yamaguchi, K. (1990). Atrial natriuretic peptide secretion in rabbits with aortic regurgitation. Research in Experimental Medicine, 190(1), 13-18. https://doi.org/10.1007/BF00000002

Atrial natriuretic peptide secretion in rabbits with aortic regurgitation. / Wainai, Yumiko; Kusuhara, M.; Yamada, T.; Yoshikawa, T.; Suzuki, M.; Hori, S.; Handa, S.; Yoshinaga, K.; Yamaguchi, K.

In: Research in Experimental Medicine, Vol. 190, No. 1, 12.1990, p. 13-18.

Research output: Contribution to journalArticle

Wainai, Y, Kusuhara, M, Yamada, T, Yoshikawa, T, Suzuki, M, Hori, S, Handa, S, Yoshinaga, K & Yamaguchi, K 1990, 'Atrial natriuretic peptide secretion in rabbits with aortic regurgitation', Research in Experimental Medicine, vol. 190, no. 1, pp. 13-18. https://doi.org/10.1007/BF00000002
Wainai, Yumiko ; Kusuhara, M. ; Yamada, T. ; Yoshikawa, T. ; Suzuki, M. ; Hori, S. ; Handa, S. ; Yoshinaga, K. ; Yamaguchi, K. / Atrial natriuretic peptide secretion in rabbits with aortic regurgitation. In: Research in Experimental Medicine. 1990 ; Vol. 190, No. 1. pp. 13-18.
@article{5768b2066c6c483c9fe98fefaa4e5437,
title = "Atrial natriuretic peptide secretion in rabbits with aortic regurgitation",
abstract = "We investigated whether or not the extent of secretion of atrial natriuretic peptide (ANP) was altered during the chronic course of aortic regurgitation (AR) in rabbits. AR was induced by aortic valve perforation in 20 rabbits. Left ventricular end-diastolic pressure (LVEDP) was used as an index of the severity of heart failure. LVEDP and plasma immunoreactive (IR)-ANP were measured before and at 15 min, 1 week, and 4 weeks after induction of AR. In each period a correlation between LVEDP and plasma IR-ANP was observed, and the coefficients and covariances did not vary throughout the experiment. We conclude, therefore, that a chronic change in ANP secretion does not develop during the first 4 weeks after induction of AR in rabbits.",
keywords = "Aortic valve insufficiency, Heart failure, congestive, Natriuretic peptides, atrial, Rabbits",
author = "Yumiko Wainai and M. Kusuhara and T. Yamada and T. Yoshikawa and M. Suzuki and S. Hori and S. Handa and K. Yoshinaga and K. Yamaguchi",
year = "1990",
month = "12",
doi = "10.1007/BF00000002",
language = "English",
volume = "190",
pages = "13--18",
journal = "Zeitschrift fü Die Gesamte Experimentelle Medizin",
issn = "1591-8890",
publisher = "Springer-Verlag Italia",
number = "1",

}

TY - JOUR

T1 - Atrial natriuretic peptide secretion in rabbits with aortic regurgitation

AU - Wainai, Yumiko

AU - Kusuhara, M.

AU - Yamada, T.

AU - Yoshikawa, T.

AU - Suzuki, M.

AU - Hori, S.

AU - Handa, S.

AU - Yoshinaga, K.

AU - Yamaguchi, K.

PY - 1990/12

Y1 - 1990/12

N2 - We investigated whether or not the extent of secretion of atrial natriuretic peptide (ANP) was altered during the chronic course of aortic regurgitation (AR) in rabbits. AR was induced by aortic valve perforation in 20 rabbits. Left ventricular end-diastolic pressure (LVEDP) was used as an index of the severity of heart failure. LVEDP and plasma immunoreactive (IR)-ANP were measured before and at 15 min, 1 week, and 4 weeks after induction of AR. In each period a correlation between LVEDP and plasma IR-ANP was observed, and the coefficients and covariances did not vary throughout the experiment. We conclude, therefore, that a chronic change in ANP secretion does not develop during the first 4 weeks after induction of AR in rabbits.

AB - We investigated whether or not the extent of secretion of atrial natriuretic peptide (ANP) was altered during the chronic course of aortic regurgitation (AR) in rabbits. AR was induced by aortic valve perforation in 20 rabbits. Left ventricular end-diastolic pressure (LVEDP) was used as an index of the severity of heart failure. LVEDP and plasma immunoreactive (IR)-ANP were measured before and at 15 min, 1 week, and 4 weeks after induction of AR. In each period a correlation between LVEDP and plasma IR-ANP was observed, and the coefficients and covariances did not vary throughout the experiment. We conclude, therefore, that a chronic change in ANP secretion does not develop during the first 4 weeks after induction of AR in rabbits.

KW - Aortic valve insufficiency

KW - Heart failure, congestive

KW - Natriuretic peptides, atrial

KW - Rabbits

UR - http://www.scopus.com/inward/record.url?scp=0025190649&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025190649&partnerID=8YFLogxK

U2 - 10.1007/BF00000002

DO - 10.1007/BF00000002

M3 - Article

C2 - 2138349

AN - SCOPUS:0025190649

VL - 190

SP - 13

EP - 18

JO - Zeitschrift fü Die Gesamte Experimentelle Medizin

JF - Zeitschrift fü Die Gesamte Experimentelle Medizin

SN - 1591-8890

IS - 1

ER -