TY - JOUR
T1 - Atrial natriuretic polypeptides
T2 - Structure-activity relationship in the central action - a comparison of their antidipsogenic actions
AU - Itoh, Hiroshi
AU - Nakao, Kazuwa
AU - Katsuura, Goro
AU - Morii, Narito
AU - Shiono, Shozo
AU - Yamada, Takayuki
AU - Sugawara, Akira
AU - Saito, Yoshihiko
AU - Watanabe, Kunio
AU - Igano, Kenichi
AU - Inouye, Ken
AU - Imura, Hiroo
N1 - Funding Information:
We thank Mrs. Hiroko Tabata and Miss Atsuko Furu for the secretarial assistance. This work was supported in part by research grants from the Japanese Ministry of Education, Science and Culture, the Japanese Ministry of Health and Welfare 'Disorders of Adrenal Hormone' Research Committee, Japan, 1986, Japan Tobacco Inc. and Yamanouchi Foundation for Research on Metabolic Disorders, by a research grant for cardiovascular diseases (60A-3) from the Japanese Ministry of Health and Welfare and by Japan Heart Foundation Research Grant For 1985.
PY - 1987/2/10
Y1 - 1987/2/10
N2 - The structure-activity relationship of atrial natriuretic polypeptides (ANPs) in the central action was investigated by examining the suppressive effects of the intracerebroventricular (i.c.v.) administration of ANPs on water intake induced by the i.c.v. injection of angiotensin II (AII) (0.1 nmol) in rats. α-Rat ANP (α-rANP), α-human ANP, α-rANP4-28 and α-rANP5-28 at a dose of 1.5 nmol exerted equipotent antidipsogenic actions, while α-rANP7-23-amide had no inhibitory effect on water drinking at this dose.
AB - The structure-activity relationship of atrial natriuretic polypeptides (ANPs) in the central action was investigated by examining the suppressive effects of the intracerebroventricular (i.c.v.) administration of ANPs on water intake induced by the i.c.v. injection of angiotensin II (AII) (0.1 nmol) in rats. α-Rat ANP (α-rANP), α-human ANP, α-rANP4-28 and α-rANP5-28 at a dose of 1.5 nmol exerted equipotent antidipsogenic actions, while α-rANP7-23-amide had no inhibitory effect on water drinking at this dose.
KW - Angiotensin II
KW - Antidipsogenic action
KW - Atrial natriuretic polypeptide
KW - Rat
KW - Structure-activity relationship
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U2 - 10.1016/0304-3940(87)90059-0
DO - 10.1016/0304-3940(87)90059-0
M3 - Article
C2 - 2951619
AN - SCOPUS:0023147132
SN - 0304-3940
VL - 74
SP - 102
EP - 106
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 1
ER -