Atrial natriuretic polypeptides: Structure-activity relationship in the central action - a comparison of their antidipsogenic actions

Hiroshi Itoh, Kazuwa Nakao, Goro Katsuura, Narito Morii, Shozo Shiono, Takayuki Yamada, Akira Sugawara, Yoshihiko Saito, Kunio Watanabe, Kenichi Igano, Ken Inouye, Hiroo Imura

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22 Citations (Scopus)

Abstract

The structure-activity relationship of atrial natriuretic polypeptides (ANPs) in the central action was investigated by examining the suppressive effects of the intracerebroventricular (i.c.v.) administration of ANPs on water intake induced by the i.c.v. injection of angiotensin II (AII) (0.1 nmol) in rats. α-Rat ANP (α-rANP), α-human ANP, α-rANP4-28 and α-rANP5-28 at a dose of 1.5 nmol exerted equipotent antidipsogenic actions, while α-rANP7-23-amide had no inhibitory effect on water drinking at this dose.

Original languageEnglish
Pages (from-to)102-106
Number of pages5
JournalNeuroscience Letters
Volume74
Issue number1
DOIs
Publication statusPublished - 1987 Feb 10
Externally publishedYes

Keywords

  • Angiotensin II
  • Antidipsogenic action
  • Atrial natriuretic polypeptide
  • Rat
  • Structure-activity relationship

ASJC Scopus subject areas

  • Neuroscience(all)

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    Itoh, H., Nakao, K., Katsuura, G., Morii, N., Shiono, S., Yamada, T., Sugawara, A., Saito, Y., Watanabe, K., Igano, K., Inouye, K., & Imura, H. (1987). Atrial natriuretic polypeptides: Structure-activity relationship in the central action - a comparison of their antidipsogenic actions. Neuroscience Letters, 74(1), 102-106. https://doi.org/10.1016/0304-3940(87)90059-0