Atypical clinical presentation of crohn’s disease with superior mesenteric vein obstruction and protein-losing enteropathy

Suguru Ito, Masaaki Higashiyama, Kazuki Horiuchi, Akinori Mizoguchi, Shigeyoshi Soga, Rina Tanemoto, Shin Nishii, Hisato Terada, Akinori Wada, Nao Sugihara, Yoshinori Hanawa, Hirotaka Furuhashi, Takeshi Takajo, Kazuhiko Shirakabe, Chikako Watanabe, Shunsuke Komoto, Kengo Tomita, Shigeaki Nagao, Masami Shinozaki, Akihiko NakagawaMichio Kubota, Daisuke Miyagishima, Nobuaki Gotoh, Soichiro Miura, Hideki Ueno, Ryota Hokari

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

We herein report a 44-year-old man suffering from systemic edema due to protein-losing enteropathy (PLE) with superior mesenteric vein (SMV) obstruction and development of collateral veins, which subsequently proved to be a chronic result of thrombosis and a complication of Crohn’s disease (CD). PLE was supposedly induced by both intestinal erosion and thrombosis-related lymphangiectasia, which was histologically proven in his surgically-resected ileal stenosis. Elemental diet and anti-TNFα agent improved his hypoalbuminemia after surgery. The rarity of the simultaneous coexistence of SMV obstruction and PLE and the precedence of these complications over typical abdominal symptoms of CD made the clinical course complex.

Original languageEnglish
Pages (from-to)369-374
Number of pages6
JournalInternal Medicine
Volume58
Issue number3
DOIs
Publication statusPublished - 2019
Externally publishedYes

Keywords

  • Crohn’s disease (CD)
  • Mesenteric vein thrombosis
  • Protein-losing enteropathy (PLE)

ASJC Scopus subject areas

  • Internal Medicine

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