Atypical endometrial hyperplasia diagnosed by hysteroscopic photodynamic diagnosis using 5-aminolevulinic acid

Yusuke Matoba, Kouji Banno, Iori Kisu, Kosuke Tsuji, Daisuke Aoki

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Endometrial cancer is diagnosed by endometrial biopsy, imaging and hysteroscopy, but it is sometimes difficult to find small lesions. 5-aminolevulinic acid (5ALA) forms protoporphyrin IX, which accumulates in tumors and fluoresces upon light irradiation. 5ALA is used for photodynamic diagnosis (PDD) for detecting malignant diseases. A 60-year-old female was suspected to have endometrial cancer by magnetic resonance imaging. Endometrial biopsy was performed repeatedly, but no malignant lesion was detected. We performed hysteroscopic 5ALA-PDD and could detect a small lesion. The lesion was excised and diagnosed as atypical endometrial hyperplasia histopathologically. This is the first report that showed hysteroscopic 5ALA-PDD can contribute to diagnosis of early-stage neoplastic lesion in the uterine cavity.

Original languageEnglish
Pages (from-to)45-47
Number of pages3
JournalPhotodiagnosis and Photodynamic Therapy
Publication statusPublished - 2019 Jun 1



  • 5-Aminolevulinic acid
  • Endometrial cancer
  • Endometrial hyperplasia
  • Hysteroscopy
  • Photodynamic diagnosis

ASJC Scopus subject areas

  • Biophysics
  • Oncology
  • Dermatology
  • Pharmacology (medical)

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