Auditory Related Resting State fMRI Functional Connectivity in Tinnitus Patients: Tinnitus Diagnosis Performance

Shujiro B. Minami, Naoki Oishi, Takahisa Watabe, Kimiichi Uno, Kaoru Ogawa

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective: The purpose of the present study was to investigate functional connectivity in tinnitus patients with and without hearing loss, and design the tinnitus diagnosis performance by resting state functional magnetic resonance imaging (rs-fMRI). Subjects and Methods: Nineteen volunteers with normal hearing without tinnitus, 18 tinnitus patients with hearing loss, and 11 tinnitus patients without hearing loss were enrolled in this study. The subjects were evaluated with rs-fMRI, and region of interests (ROIs) based correlation analyses were performed using the CONN toolbox version 16 and SPM version 8. The correlation coefficients from individual level results were converted into beta values. Results: With a beta threshold of more than 0.2, 91% of all possible connections between auditory-related ROIs (Heschl's gyrus, planum temporale, planum polare, operculum, insular cortex, superior temporal gyrus) in the control group remained intact, whereas 83 and 66% of such connections were present in the hearing loss and the normal-hearing tinnitus group. However, between non-auditory-related ROIs, the rates of intact connections at a beta threshold of more than 0.2 were 17% in the control group, and 16 and 15% in the tinnitus groups. When resting state fMRI positive is defined as less than 9% of all possible connections between auditory-related ROIs with a beta threshold of more than 0.7, the sensitivity and specificity of tinnitus diagnosis is 86 and 74%, respectively. Conclusions: The associations between auditory-related networks are weakened in tinnitus patients, even if they have normal hearing. It is possible that rs-fMRI can be a tool for objective examination of tinnitus, by focusing the auditory-related areas.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalOtology and Neurotology
Volume39
Issue number1
DOIs
Publication statusPublished - 2018 Jan 1

Fingerprint

Tinnitus
Magnetic Resonance Imaging
Hearing Loss
Hearing
Auditory Cortex
Temporal Lobe
Control Groups
Temazepam
Cerebral Cortex
Healthy Volunteers
Sensitivity and Specificity

Keywords

  • Auditory association cortex
  • Functional magnetic resonance imaging
  • Normal hearing tinnitus

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Sensory Systems
  • Clinical Neurology

Cite this

Auditory Related Resting State fMRI Functional Connectivity in Tinnitus Patients : Tinnitus Diagnosis Performance. / Minami, Shujiro B.; Oishi, Naoki; Watabe, Takahisa; Uno, Kimiichi; Ogawa, Kaoru.

In: Otology and Neurotology, Vol. 39, No. 1, 01.01.2018, p. 1-5.

Research output: Contribution to journalArticle

@article{c608a40aeee54036b569643eceb087f6,
title = "Auditory Related Resting State fMRI Functional Connectivity in Tinnitus Patients: Tinnitus Diagnosis Performance",
abstract = "Objective: The purpose of the present study was to investigate functional connectivity in tinnitus patients with and without hearing loss, and design the tinnitus diagnosis performance by resting state functional magnetic resonance imaging (rs-fMRI). Subjects and Methods: Nineteen volunteers with normal hearing without tinnitus, 18 tinnitus patients with hearing loss, and 11 tinnitus patients without hearing loss were enrolled in this study. The subjects were evaluated with rs-fMRI, and region of interests (ROIs) based correlation analyses were performed using the CONN toolbox version 16 and SPM version 8. The correlation coefficients from individual level results were converted into beta values. Results: With a beta threshold of more than 0.2, 91{\%} of all possible connections between auditory-related ROIs (Heschl's gyrus, planum temporale, planum polare, operculum, insular cortex, superior temporal gyrus) in the control group remained intact, whereas 83 and 66{\%} of such connections were present in the hearing loss and the normal-hearing tinnitus group. However, between non-auditory-related ROIs, the rates of intact connections at a beta threshold of more than 0.2 were 17{\%} in the control group, and 16 and 15{\%} in the tinnitus groups. When resting state fMRI positive is defined as less than 9{\%} of all possible connections between auditory-related ROIs with a beta threshold of more than 0.7, the sensitivity and specificity of tinnitus diagnosis is 86 and 74{\%}, respectively. Conclusions: The associations between auditory-related networks are weakened in tinnitus patients, even if they have normal hearing. It is possible that rs-fMRI can be a tool for objective examination of tinnitus, by focusing the auditory-related areas.",
keywords = "Auditory association cortex, Functional magnetic resonance imaging, Normal hearing tinnitus",
author = "Minami, {Shujiro B.} and Naoki Oishi and Takahisa Watabe and Kimiichi Uno and Kaoru Ogawa",
year = "2018",
month = "1",
day = "1",
doi = "10.1097/MAO.0000000000001626",
language = "English",
volume = "39",
pages = "1--5",
journal = "Otology and Neurotology",
issn = "1531-7129",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Auditory Related Resting State fMRI Functional Connectivity in Tinnitus Patients

T2 - Tinnitus Diagnosis Performance

AU - Minami, Shujiro B.

AU - Oishi, Naoki

AU - Watabe, Takahisa

AU - Uno, Kimiichi

AU - Ogawa, Kaoru

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Objective: The purpose of the present study was to investigate functional connectivity in tinnitus patients with and without hearing loss, and design the tinnitus diagnosis performance by resting state functional magnetic resonance imaging (rs-fMRI). Subjects and Methods: Nineteen volunteers with normal hearing without tinnitus, 18 tinnitus patients with hearing loss, and 11 tinnitus patients without hearing loss were enrolled in this study. The subjects were evaluated with rs-fMRI, and region of interests (ROIs) based correlation analyses were performed using the CONN toolbox version 16 and SPM version 8. The correlation coefficients from individual level results were converted into beta values. Results: With a beta threshold of more than 0.2, 91% of all possible connections between auditory-related ROIs (Heschl's gyrus, planum temporale, planum polare, operculum, insular cortex, superior temporal gyrus) in the control group remained intact, whereas 83 and 66% of such connections were present in the hearing loss and the normal-hearing tinnitus group. However, between non-auditory-related ROIs, the rates of intact connections at a beta threshold of more than 0.2 were 17% in the control group, and 16 and 15% in the tinnitus groups. When resting state fMRI positive is defined as less than 9% of all possible connections between auditory-related ROIs with a beta threshold of more than 0.7, the sensitivity and specificity of tinnitus diagnosis is 86 and 74%, respectively. Conclusions: The associations between auditory-related networks are weakened in tinnitus patients, even if they have normal hearing. It is possible that rs-fMRI can be a tool for objective examination of tinnitus, by focusing the auditory-related areas.

AB - Objective: The purpose of the present study was to investigate functional connectivity in tinnitus patients with and without hearing loss, and design the tinnitus diagnosis performance by resting state functional magnetic resonance imaging (rs-fMRI). Subjects and Methods: Nineteen volunteers with normal hearing without tinnitus, 18 tinnitus patients with hearing loss, and 11 tinnitus patients without hearing loss were enrolled in this study. The subjects were evaluated with rs-fMRI, and region of interests (ROIs) based correlation analyses were performed using the CONN toolbox version 16 and SPM version 8. The correlation coefficients from individual level results were converted into beta values. Results: With a beta threshold of more than 0.2, 91% of all possible connections between auditory-related ROIs (Heschl's gyrus, planum temporale, planum polare, operculum, insular cortex, superior temporal gyrus) in the control group remained intact, whereas 83 and 66% of such connections were present in the hearing loss and the normal-hearing tinnitus group. However, between non-auditory-related ROIs, the rates of intact connections at a beta threshold of more than 0.2 were 17% in the control group, and 16 and 15% in the tinnitus groups. When resting state fMRI positive is defined as less than 9% of all possible connections between auditory-related ROIs with a beta threshold of more than 0.7, the sensitivity and specificity of tinnitus diagnosis is 86 and 74%, respectively. Conclusions: The associations between auditory-related networks are weakened in tinnitus patients, even if they have normal hearing. It is possible that rs-fMRI can be a tool for objective examination of tinnitus, by focusing the auditory-related areas.

KW - Auditory association cortex

KW - Functional magnetic resonance imaging

KW - Normal hearing tinnitus

UR - http://www.scopus.com/inward/record.url?scp=85039460238&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85039460238&partnerID=8YFLogxK

U2 - 10.1097/MAO.0000000000001626

DO - 10.1097/MAO.0000000000001626

M3 - Article

C2 - 29210942

AN - SCOPUS:85039460238

VL - 39

SP - 1

EP - 5

JO - Otology and Neurotology

JF - Otology and Neurotology

SN - 1531-7129

IS - 1

ER -