Auditory resting-state functional connectivity in tinnitus and modulation with transcranial direct current stimulation

Shujiro B. Minami, Naoki Oishi, Takahisa Watabe, Kimiichi Uno, Kimitaka Kaga, Kaoru Ogawa

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Conclusions: The functional connectivity (FC) between the right and left auditory cortex is weak in tinnitus patients. Transcranial direct current stimulation (tDCS) over the auditory cortex has potential as a tool to modulate auditory-based FC. Objective: This study investigated the effects of applying tDCS in tinnitus patients, and searched for modulation of brain networks in resting-state functional magnetic resonance imaging (rs-fMRI) through an analysis of FC with the stimulated brain region. Subjects and methods: Nine male patients with chronic tinnitus and 10 male volunteers with normal hearing were enrolled. The subjects were evaluated with rs-fMRI immediately before and after tDCS. The tinnitus patients filled out the self-evaluation questionnaires designed to measure tinnitus conditions before tDCS treatment and 1 week afterwards. Results: The FC between the right and left auditory cortex was significantly weaker in tinnitus patients than in controls. After tDCS treatment, in the tinnitus group, the primary auditory cortex showed a reduction in the amount of statistically significant connectivity with the somatosensory area and motor area, but maintained strong significant connectivity (p < 0.005) with the auditory area and insular cortex. In contrast, in the control group, there remained strong significant connectivity between the primary auditory cortex and the somatosensory area, motor area, insular cortex, and auditory area.

Original languageEnglish
Pages (from-to)1286-1292
Number of pages7
JournalActa Oto-Laryngologica
Volume135
Issue number12
DOIs
Publication statusPublished - 2015 Dec 2

Fingerprint

Auditory Cortex
Tinnitus
Motor Cortex
Cerebral Cortex
Magnetic Resonance Imaging
Diagnostic Self Evaluation
Transcranial Direct Current Stimulation
Brain
Hearing
Healthy Volunteers
Control Groups
Therapeutics

Keywords

  • auditory cortex
  • hearing
  • Magnetic resonance imaging
  • motor cortex
  • somatosensory cortex

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Auditory resting-state functional connectivity in tinnitus and modulation with transcranial direct current stimulation. / Minami, Shujiro B.; Oishi, Naoki; Watabe, Takahisa; Uno, Kimiichi; Kaga, Kimitaka; Ogawa, Kaoru.

In: Acta Oto-Laryngologica, Vol. 135, No. 12, 02.12.2015, p. 1286-1292.

Research output: Contribution to journalArticle

Minami, Shujiro B. ; Oishi, Naoki ; Watabe, Takahisa ; Uno, Kimiichi ; Kaga, Kimitaka ; Ogawa, Kaoru. / Auditory resting-state functional connectivity in tinnitus and modulation with transcranial direct current stimulation. In: Acta Oto-Laryngologica. 2015 ; Vol. 135, No. 12. pp. 1286-1292.
@article{b4ba8ca75e874599890b8baf9fbbc196,
title = "Auditory resting-state functional connectivity in tinnitus and modulation with transcranial direct current stimulation",
abstract = "Conclusions: The functional connectivity (FC) between the right and left auditory cortex is weak in tinnitus patients. Transcranial direct current stimulation (tDCS) over the auditory cortex has potential as a tool to modulate auditory-based FC. Objective: This study investigated the effects of applying tDCS in tinnitus patients, and searched for modulation of brain networks in resting-state functional magnetic resonance imaging (rs-fMRI) through an analysis of FC with the stimulated brain region. Subjects and methods: Nine male patients with chronic tinnitus and 10 male volunteers with normal hearing were enrolled. The subjects were evaluated with rs-fMRI immediately before and after tDCS. The tinnitus patients filled out the self-evaluation questionnaires designed to measure tinnitus conditions before tDCS treatment and 1 week afterwards. Results: The FC between the right and left auditory cortex was significantly weaker in tinnitus patients than in controls. After tDCS treatment, in the tinnitus group, the primary auditory cortex showed a reduction in the amount of statistically significant connectivity with the somatosensory area and motor area, but maintained strong significant connectivity (p < 0.005) with the auditory area and insular cortex. In contrast, in the control group, there remained strong significant connectivity between the primary auditory cortex and the somatosensory area, motor area, insular cortex, and auditory area.",
keywords = "auditory cortex, hearing, Magnetic resonance imaging, motor cortex, somatosensory cortex",
author = "Minami, {Shujiro B.} and Naoki Oishi and Takahisa Watabe and Kimiichi Uno and Kimitaka Kaga and Kaoru Ogawa",
year = "2015",
month = "12",
day = "2",
doi = "10.3109/00016489.2015.1068952",
language = "English",
volume = "135",
pages = "1286--1292",
journal = "Acta Oto-Laryngologica",
issn = "0001-6489",
publisher = "Informa Healthcare",
number = "12",

}

TY - JOUR

T1 - Auditory resting-state functional connectivity in tinnitus and modulation with transcranial direct current stimulation

AU - Minami, Shujiro B.

AU - Oishi, Naoki

AU - Watabe, Takahisa

AU - Uno, Kimiichi

AU - Kaga, Kimitaka

AU - Ogawa, Kaoru

PY - 2015/12/2

Y1 - 2015/12/2

N2 - Conclusions: The functional connectivity (FC) between the right and left auditory cortex is weak in tinnitus patients. Transcranial direct current stimulation (tDCS) over the auditory cortex has potential as a tool to modulate auditory-based FC. Objective: This study investigated the effects of applying tDCS in tinnitus patients, and searched for modulation of brain networks in resting-state functional magnetic resonance imaging (rs-fMRI) through an analysis of FC with the stimulated brain region. Subjects and methods: Nine male patients with chronic tinnitus and 10 male volunteers with normal hearing were enrolled. The subjects were evaluated with rs-fMRI immediately before and after tDCS. The tinnitus patients filled out the self-evaluation questionnaires designed to measure tinnitus conditions before tDCS treatment and 1 week afterwards. Results: The FC between the right and left auditory cortex was significantly weaker in tinnitus patients than in controls. After tDCS treatment, in the tinnitus group, the primary auditory cortex showed a reduction in the amount of statistically significant connectivity with the somatosensory area and motor area, but maintained strong significant connectivity (p < 0.005) with the auditory area and insular cortex. In contrast, in the control group, there remained strong significant connectivity between the primary auditory cortex and the somatosensory area, motor area, insular cortex, and auditory area.

AB - Conclusions: The functional connectivity (FC) between the right and left auditory cortex is weak in tinnitus patients. Transcranial direct current stimulation (tDCS) over the auditory cortex has potential as a tool to modulate auditory-based FC. Objective: This study investigated the effects of applying tDCS in tinnitus patients, and searched for modulation of brain networks in resting-state functional magnetic resonance imaging (rs-fMRI) through an analysis of FC with the stimulated brain region. Subjects and methods: Nine male patients with chronic tinnitus and 10 male volunteers with normal hearing were enrolled. The subjects were evaluated with rs-fMRI immediately before and after tDCS. The tinnitus patients filled out the self-evaluation questionnaires designed to measure tinnitus conditions before tDCS treatment and 1 week afterwards. Results: The FC between the right and left auditory cortex was significantly weaker in tinnitus patients than in controls. After tDCS treatment, in the tinnitus group, the primary auditory cortex showed a reduction in the amount of statistically significant connectivity with the somatosensory area and motor area, but maintained strong significant connectivity (p < 0.005) with the auditory area and insular cortex. In contrast, in the control group, there remained strong significant connectivity between the primary auditory cortex and the somatosensory area, motor area, insular cortex, and auditory area.

KW - auditory cortex

KW - hearing

KW - Magnetic resonance imaging

KW - motor cortex

KW - somatosensory cortex

UR - http://www.scopus.com/inward/record.url?scp=84942435471&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84942435471&partnerID=8YFLogxK

U2 - 10.3109/00016489.2015.1068952

DO - 10.3109/00016489.2015.1068952

M3 - Article

VL - 135

SP - 1286

EP - 1292

JO - Acta Oto-Laryngologica

JF - Acta Oto-Laryngologica

SN - 0001-6489

IS - 12

ER -