Augmented expression of CD44 splice variants in lymphoproliferative disorder of the lacrimal gland in Sjogren's syndrome

Miki Hiraoka, Ichiro Saito, Kazuo Tsubota, Susumu Sugai, Nobuyuki Miyasaka

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We explored the involvement of CD44 isoforms in lymphoproliferative disorder (LPD) of the lacrimal gland of a Sjogren's syndrome patient with unilateral LPD. The CD44 variant with the v6 exon was selectively detected from infiltrating lymphocytes in the gland with LPD, but not from infiltrating lymphocytes in the normal lacrimal gland, suggesting that the CD44 v6 variant exon may be closely associated with the development of LPD in Sjogren's syndrome.

Original languageEnglish
Pages (from-to)312-318
Number of pages7
JournalJapanese Journal of Ophthalmology
Volume41
Issue number5
DOIs
Publication statusPublished - 1997 Sep 1
Externally publishedYes

Keywords

  • CD44 splice variant
  • Lacrimal gland
  • Lymphoproliferative disorder
  • Sjogren's syndrome

ASJC Scopus subject areas

  • Ophthalmology

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