Augmented expression of CD44 splice variants in lymphoproliferative disorder of the lacrimal gland in Sjogren's syndrome

Miki Hiraoka; Ichiro Saito; Kazuo Tsubota; Susumu Sugai; Nobuyuki Miyasaka

doi:10.1016/S0021-5155(97)00072-5

Augmented expression of CD44 splice variants in lymphoproliferative disorder of the lacrimal gland in Sjogren's syndrome

Miki Hiraoka, Ichiro Saito, Kazuo Tsubota, Susumu Sugai, Nobuyuki Miyasaka

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

We explored the involvement of CD44 isoforms in lymphoproliferative disorder (LPD) of the lacrimal gland of a Sjogren's syndrome patient with unilateral LPD. The CD44 variant with the v6 exon was selectively detected from infiltrating lymphocytes in the gland with LPD, but not from infiltrating lymphocytes in the normal lacrimal gland, suggesting that the CD44 v6 variant exon may be closely associated with the development of LPD in Sjogren's syndrome.

Original language	English
Pages (from-to)	312-318
Number of pages	7
Journal	Japanese Journal of Ophthalmology
Volume	41
Issue number	5
DOIs	https://doi.org/10.1016/S0021-5155(97)00072-5
Publication status	Published - 1997 Sep
Externally published	Yes

Keywords

CD44 splice variant
Lacrimal gland
Lymphoproliferative disorder
Sjogren's syndrome

ASJC Scopus subject areas

Ophthalmology

Access to Document

10.1016/S0021-5155(97)00072-5

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title = "Augmented expression of CD44 splice variants in lymphoproliferative disorder of the lacrimal gland in Sjogren's syndrome",

abstract = "We explored the involvement of CD44 isoforms in lymphoproliferative disorder (LPD) of the lacrimal gland of a Sjogren's syndrome patient with unilateral LPD. The CD44 variant with the v6 exon was selectively detected from infiltrating lymphocytes in the gland with LPD, but not from infiltrating lymphocytes in the normal lacrimal gland, suggesting that the CD44 v6 variant exon may be closely associated with the development of LPD in Sjogren's syndrome.",

keywords = "CD44 splice variant, Lacrimal gland, Lymphoproliferative disorder, Sjogren's syndrome",

author = "Miki Hiraoka and Ichiro Saito and Kazuo Tsubota and Susumu Sugai and Nobuyuki Miyasaka",

year = "1997",

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T1 - Augmented expression of CD44 splice variants in lymphoproliferative disorder of the lacrimal gland in Sjogren's syndrome

AU - Hiraoka, Miki

AU - Saito, Ichiro

AU - Tsubota, Kazuo

AU - Sugai, Susumu

AU - Miyasaka, Nobuyuki

PY - 1997/9

Y1 - 1997/9

N2 - We explored the involvement of CD44 isoforms in lymphoproliferative disorder (LPD) of the lacrimal gland of a Sjogren's syndrome patient with unilateral LPD. The CD44 variant with the v6 exon was selectively detected from infiltrating lymphocytes in the gland with LPD, but not from infiltrating lymphocytes in the normal lacrimal gland, suggesting that the CD44 v6 variant exon may be closely associated with the development of LPD in Sjogren's syndrome.

AB - We explored the involvement of CD44 isoforms in lymphoproliferative disorder (LPD) of the lacrimal gland of a Sjogren's syndrome patient with unilateral LPD. The CD44 variant with the v6 exon was selectively detected from infiltrating lymphocytes in the gland with LPD, but not from infiltrating lymphocytes in the normal lacrimal gland, suggesting that the CD44 v6 variant exon may be closely associated with the development of LPD in Sjogren's syndrome.

KW - CD44 splice variant

KW - Lacrimal gland

KW - Lymphoproliferative disorder

KW - Sjogren's syndrome

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