AUGMENTED EXPRESSION OF THE ENDOTHELIN‐A RECEPTOR GENE IN CULTURED MESANGIAL CELLS FROM STROKE‐PRONE SPONTANEOUSLY HYPERTENSIVE RATS

Junko Hiraoka, Hiroshi Arai, Takaaki Yoshimasa, Kazuhiko Takaya, Yoshihiro Miyamoto, Jun Yamashita, Shin‐ichi ‐i Suga, Yoshihiro Ogawa, Gotaro Shirakami, Hiroshi Itoh, Yukio Yamori, Kazuwa Nakao

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

1. To elucidate the role of endothelin (ET) receptor in hypertension, we studied the expression of the ET‐A receptor (ET‐ AR) gene and the ET‐B receptor (ET‐BR) gene in cultured mesangial cells isolated from stroke‐prone spontaneously hypertensive rats (SHRSP) and Wistar‐Kyoto (WKY) rats. 2. The mesangial cells from both SHRSP and WKY expressed ET‐AR predominantly. The level of the ET‐AR mRNA in mesangial cells from SHRSP was 5‐fold higher than that in the cells from WKY. The ET‐BR mRNA in the mesangial cells from both strains was hardly detectable by northern blot analysis. 3. These results demonstrate that the expression of the ET‐AR gene was markedly augmented in mesangial cells from SHRSP.

Original languageEnglish
Pages (from-to)S191-S192
JournalClinical and Experimental Pharmacology and Physiology
Volume22
DOIs
Publication statusPublished - 1995 Nov
Externally publishedYes

Keywords

  • Wistar‐Kyoto rat
  • endothelin
  • endothelin receptor
  • gene expression
  • glomerular mesangial cells
  • hypertension
  • stroke‐prone spontaneously hypertensive rat

ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Physiology (medical)

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  • Cite this

    Hiraoka, J., Arai, H., Yoshimasa, T., Takaya, K., Miyamoto, Y., Yamashita, J., Suga, S. ., Ogawa, Y., Shirakami, G., Itoh, H., Yamori, Y., & Nakao, K. (1995). AUGMENTED EXPRESSION OF THE ENDOTHELIN‐A RECEPTOR GENE IN CULTURED MESANGIAL CELLS FROM STROKE‐PRONE SPONTANEOUSLY HYPERTENSIVE RATS. Clinical and Experimental Pharmacology and Physiology, 22, S191-S192. https://doi.org/10.1111/j.1440-1681.1995.tb02876.x