Augmented plasma protein C activity after coronary thrombolysis with urokinase in patients with acute myocardial infarction

S. Goto, S. Handa, Y. Kawai, K. Watanabe, S. Abe, E. Takahashi, S. Hori, Y. Ikeda

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Coronary thrombolysis reduces morbidity and mortality in patients with acute myocardial infarction, however, the exact effects of thrombolytic agents on the status of intrinsic hemostases are not fully understood. In the present study, we examined serial changes in plasma thrombin and protein C activities of 6 patients with acute myocardial infarction treated with urokinase. Fibrinolysis occurred immediately after urokinase injection with an increase in the plasma thrombin-antithrombin III complex, suggesting a subsequent procoagulant state due to thrombin generation. Correspondent increases in plasma protein C activity were observed, however, protein S levels did not change at all. Our findings suggest that urokinase administration for coronary thrombolysis not only causes fibrinolysis, but also induces thrombin activity, which may be antagonized by augmented intrinsic protein C activity.

Original languageEnglish
Pages (from-to)252-256
Number of pages5
JournalCardiology
Volume80
Issue number3-4
Publication statusPublished - 1992

Fingerprint

Urokinase-Type Plasminogen Activator
Protein C
Thrombin
Blood Proteins
Myocardial Infarction
Fibrinolysis
Fibrinolytic Agents
Protein S
Morbidity
Injections
Mortality

Keywords

  • Coronary thrombolysis
  • Myocardial infarction
  • Protein C
  • Protein S
  • Urokinase

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Goto, S., Handa, S., Kawai, Y., Watanabe, K., Abe, S., Takahashi, E., ... Ikeda, Y. (1992). Augmented plasma protein C activity after coronary thrombolysis with urokinase in patients with acute myocardial infarction. Cardiology, 80(3-4), 252-256.

Augmented plasma protein C activity after coronary thrombolysis with urokinase in patients with acute myocardial infarction. / Goto, S.; Handa, S.; Kawai, Y.; Watanabe, K.; Abe, S.; Takahashi, E.; Hori, S.; Ikeda, Y.

In: Cardiology, Vol. 80, No. 3-4, 1992, p. 252-256.

Research output: Contribution to journalArticle

Goto, S, Handa, S, Kawai, Y, Watanabe, K, Abe, S, Takahashi, E, Hori, S & Ikeda, Y 1992, 'Augmented plasma protein C activity after coronary thrombolysis with urokinase in patients with acute myocardial infarction', Cardiology, vol. 80, no. 3-4, pp. 252-256.
Goto S, Handa S, Kawai Y, Watanabe K, Abe S, Takahashi E et al. Augmented plasma protein C activity after coronary thrombolysis with urokinase in patients with acute myocardial infarction. Cardiology. 1992;80(3-4):252-256.
Goto, S. ; Handa, S. ; Kawai, Y. ; Watanabe, K. ; Abe, S. ; Takahashi, E. ; Hori, S. ; Ikeda, Y. / Augmented plasma protein C activity after coronary thrombolysis with urokinase in patients with acute myocardial infarction. In: Cardiology. 1992 ; Vol. 80, No. 3-4. pp. 252-256.
@article{d380052bc5d94f96becb10defedee850,
title = "Augmented plasma protein C activity after coronary thrombolysis with urokinase in patients with acute myocardial infarction",
abstract = "Coronary thrombolysis reduces morbidity and mortality in patients with acute myocardial infarction, however, the exact effects of thrombolytic agents on the status of intrinsic hemostases are not fully understood. In the present study, we examined serial changes in plasma thrombin and protein C activities of 6 patients with acute myocardial infarction treated with urokinase. Fibrinolysis occurred immediately after urokinase injection with an increase in the plasma thrombin-antithrombin III complex, suggesting a subsequent procoagulant state due to thrombin generation. Correspondent increases in plasma protein C activity were observed, however, protein S levels did not change at all. Our findings suggest that urokinase administration for coronary thrombolysis not only causes fibrinolysis, but also induces thrombin activity, which may be antagonized by augmented intrinsic protein C activity.",
keywords = "Coronary thrombolysis, Myocardial infarction, Protein C, Protein S, Urokinase",
author = "S. Goto and S. Handa and Y. Kawai and K. Watanabe and S. Abe and E. Takahashi and S. Hori and Y. Ikeda",
year = "1992",
language = "English",
volume = "80",
pages = "252--256",
journal = "Cardiology (Switzerland)",
issn = "0008-6312",
publisher = "S. Karger AG",
number = "3-4",

}

TY - JOUR

T1 - Augmented plasma protein C activity after coronary thrombolysis with urokinase in patients with acute myocardial infarction

AU - Goto, S.

AU - Handa, S.

AU - Kawai, Y.

AU - Watanabe, K.

AU - Abe, S.

AU - Takahashi, E.

AU - Hori, S.

AU - Ikeda, Y.

PY - 1992

Y1 - 1992

N2 - Coronary thrombolysis reduces morbidity and mortality in patients with acute myocardial infarction, however, the exact effects of thrombolytic agents on the status of intrinsic hemostases are not fully understood. In the present study, we examined serial changes in plasma thrombin and protein C activities of 6 patients with acute myocardial infarction treated with urokinase. Fibrinolysis occurred immediately after urokinase injection with an increase in the plasma thrombin-antithrombin III complex, suggesting a subsequent procoagulant state due to thrombin generation. Correspondent increases in plasma protein C activity were observed, however, protein S levels did not change at all. Our findings suggest that urokinase administration for coronary thrombolysis not only causes fibrinolysis, but also induces thrombin activity, which may be antagonized by augmented intrinsic protein C activity.

AB - Coronary thrombolysis reduces morbidity and mortality in patients with acute myocardial infarction, however, the exact effects of thrombolytic agents on the status of intrinsic hemostases are not fully understood. In the present study, we examined serial changes in plasma thrombin and protein C activities of 6 patients with acute myocardial infarction treated with urokinase. Fibrinolysis occurred immediately after urokinase injection with an increase in the plasma thrombin-antithrombin III complex, suggesting a subsequent procoagulant state due to thrombin generation. Correspondent increases in plasma protein C activity were observed, however, protein S levels did not change at all. Our findings suggest that urokinase administration for coronary thrombolysis not only causes fibrinolysis, but also induces thrombin activity, which may be antagonized by augmented intrinsic protein C activity.

KW - Coronary thrombolysis

KW - Myocardial infarction

KW - Protein C

KW - Protein S

KW - Urokinase

UR - http://www.scopus.com/inward/record.url?scp=0026692936&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026692936&partnerID=8YFLogxK

M3 - Article

C2 - 1387346

AN - SCOPUS:0026692936

VL - 80

SP - 252

EP - 256

JO - Cardiology (Switzerland)

JF - Cardiology (Switzerland)

SN - 0008-6312

IS - 3-4

ER -