Augmented plasma protein C activity after coronary thrombolysis with urokinase in patients with acute myocardial infarction

Shinya Goto, Shunnosuke Handa, Yohko Kawai, Kiyoaki Watanabe, Sumihisa Abe, Eiichi Takahashi, Shingo Hori, Yasuo Ikeda

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Coronary thrombolysis reduces morbidity and mortality in patients with acute myocardial infarction, however, the exact effects of thrombolytic agents on the status of intrinsic hemos-tases are not fully understood. In the present study, we examined serial changes in plasma thrombin and protein C activities of 6 patients with acute myocardial infarction treated with urokinase. Fibrinolysis occurred immediately after urokinase injection with an increase in the plasma thrombin-antithrom-bin III complex, suggesting a subsequent procoagulant state due to thrombin generation. Correspondent increases in plasma protein C activity were observed, however, protein S levels did not change at all. Our findings suggest that urokinase administration for coronary thrombolysis not only causes fibrinolysis, but also induces thrombin activity, which may be antagonized by augmented intrinsic protein Cactivity.

Original languageEnglish
Pages (from-to)252-256
Number of pages5
JournalCardiology (Switzerland)
Volume80
Issue number3-4
DOIs
Publication statusPublished - 1992 Jan 1

Keywords

  • Coronary thrombolysis
  • Myocardial infarction
  • Protein C
  • Protein S
  • Urokinase

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Augmented plasma protein C activity after coronary thrombolysis with urokinase in patients with acute myocardial infarction'. Together they form a unique fingerprint.

  • Cite this

    Goto, S., Handa, S., Kawai, Y., Watanabe, K., Abe, S., Takahashi, E., Hori, S., & Ikeda, Y. (1992). Augmented plasma protein C activity after coronary thrombolysis with urokinase in patients with acute myocardial infarction. Cardiology (Switzerland), 80(3-4), 252-256. https://doi.org/10.1159/000175010