TY - JOUR
T1 - Augmented synthesis of β-human atrial natriuretic polypeptide in human failing hearts
AU - Sugawara, Akira
AU - Nakao, Kazuwa
AU - Morii, Narito
AU - Yamada, Takayuki
AU - Itoh, Hiroshi
AU - Shiono, Shozo
AU - Saito, Yoshihiko
AU - Mukoyama, Masashi
AU - Arai, Hiroshi
AU - Nishimura, Kazunobu
AU - Obata, Kenji
AU - Yasue, Hirofumi
AU - Ban, Toshihiko
AU - Imura, Hiroo
PY - 1988/1/15
Y1 - 1988/1/15
N2 - To elucidate the synthesis of atrial natriuretic polypeptide (ANP) in the failing heart, eighteen human right auricles obtained at cardiovascular surgery were studied. The concentration of α-human ANP-like immunoreactivity (α-hANP-LI) in human right auricles ranged from 13.8 to 593.5 μg/g, and the tissue α-hANP-LI concentration in severe congestive heart failure (CHF) (New York Heart Association (NYHA) functional class III or IV) was much higher than those in mild CHF of NYHA class I and class II. The α-hANP-LI in the human auricle consisted of 3 major components of ANP, γ-human ANP (γ-hANP), β-human ANP (β-hANP) and α-human ANP (α-hANP). The predominant component of α-hANP-LI was γ-hANP in the mild CHF, whereas β-hANP and/or α-hANP were prevailing in the severe CHF and, especially, β-hANP was markedly increased in human failing hearts.
AB - To elucidate the synthesis of atrial natriuretic polypeptide (ANP) in the failing heart, eighteen human right auricles obtained at cardiovascular surgery were studied. The concentration of α-human ANP-like immunoreactivity (α-hANP-LI) in human right auricles ranged from 13.8 to 593.5 μg/g, and the tissue α-hANP-LI concentration in severe congestive heart failure (CHF) (New York Heart Association (NYHA) functional class III or IV) was much higher than those in mild CHF of NYHA class I and class II. The α-hANP-LI in the human auricle consisted of 3 major components of ANP, γ-human ANP (γ-hANP), β-human ANP (β-hANP) and α-human ANP (α-hANP). The predominant component of α-hANP-LI was γ-hANP in the mild CHF, whereas β-hANP and/or α-hANP were prevailing in the severe CHF and, especially, β-hANP was markedly increased in human failing hearts.
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U2 - 10.1016/0006-291X(88)90486-X
DO - 10.1016/0006-291X(88)90486-X
M3 - Article
C2 - 2962584
AN - SCOPUS:0023868313
VL - 150
SP - 60
EP - 67
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 1
ER -