Abstract
To elucidate the synthesis of atrial natriuretic polypeptide (ANP) in the failing heart, eighteen human right auricles obtained at cardiovascular surgery were studied. The concentration of α-human ANP-like immunoreactivity (α-hANP-LI) in human right auricles ranged from 13.8 to 593.5 μg/g, and the tissue α-hANP-LI concentration in severe congestive heart failure (CHF) (New York Heart Association (NYHA) functional class III or IV) was much higher than those in mild CHF of NYHA class I and class II. The α-hANP-LI in the human auricle consisted of 3 major components of ANP, γ-human ANP (γ-hANP), β-human ANP (β-hANP) and α-human ANP (α-hANP). The predominant component of α-hANP-LI was γ-hANP in the mild CHF, whereas β-hANP and/or α-hANP were prevailing in the severe CHF and, especially, β-hANP was markedly increased in human failing hearts.
| Original language | English |
|---|---|
| Pages (from-to) | 60-67 |
| Number of pages | 8 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 150 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1988 Jan 15 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Molecular Biology
Cite this
Augmented synthesis of β-human atrial natriuretic polypeptide in human failing hearts. / Sugawara, Akira; Nakao, Kazuwa; Morii, Narito; Yamada, Takayuki; Itoh, Hiroshi; Shiono, Shozo; Saito, Yoshihiko; Mukoyama, Masashi; Arai, Hiroshi; Nishimura, Kazunobu; Obata, Kenji; Yasue, Hirofumi; Ban, Toshihiko; Imura, Hiroo.
In: Biochemical and Biophysical Research Communications, Vol. 150, No. 1, 15.01.1988, p. 60-67.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Augmented synthesis of β-human atrial natriuretic polypeptide in human failing hearts
AU - Sugawara, Akira
AU - Nakao, Kazuwa
AU - Morii, Narito
AU - Yamada, Takayuki
AU - Itoh, Hiroshi
AU - Shiono, Shozo
AU - Saito, Yoshihiko
AU - Mukoyama, Masashi
AU - Arai, Hiroshi
AU - Nishimura, Kazunobu
AU - Obata, Kenji
AU - Yasue, Hirofumi
AU - Ban, Toshihiko
AU - Imura, Hiroo
PY - 1988/1/15
Y1 - 1988/1/15
N2 - To elucidate the synthesis of atrial natriuretic polypeptide (ANP) in the failing heart, eighteen human right auricles obtained at cardiovascular surgery were studied. The concentration of α-human ANP-like immunoreactivity (α-hANP-LI) in human right auricles ranged from 13.8 to 593.5 μg/g, and the tissue α-hANP-LI concentration in severe congestive heart failure (CHF) (New York Heart Association (NYHA) functional class III or IV) was much higher than those in mild CHF of NYHA class I and class II. The α-hANP-LI in the human auricle consisted of 3 major components of ANP, γ-human ANP (γ-hANP), β-human ANP (β-hANP) and α-human ANP (α-hANP). The predominant component of α-hANP-LI was γ-hANP in the mild CHF, whereas β-hANP and/or α-hANP were prevailing in the severe CHF and, especially, β-hANP was markedly increased in human failing hearts.
AB - To elucidate the synthesis of atrial natriuretic polypeptide (ANP) in the failing heart, eighteen human right auricles obtained at cardiovascular surgery were studied. The concentration of α-human ANP-like immunoreactivity (α-hANP-LI) in human right auricles ranged from 13.8 to 593.5 μg/g, and the tissue α-hANP-LI concentration in severe congestive heart failure (CHF) (New York Heart Association (NYHA) functional class III or IV) was much higher than those in mild CHF of NYHA class I and class II. The α-hANP-LI in the human auricle consisted of 3 major components of ANP, γ-human ANP (γ-hANP), β-human ANP (β-hANP) and α-human ANP (α-hANP). The predominant component of α-hANP-LI was γ-hANP in the mild CHF, whereas β-hANP and/or α-hANP were prevailing in the severe CHF and, especially, β-hANP was markedly increased in human failing hearts.
UR - http://www.scopus.com/inward/record.url?scp=0023868313&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023868313&partnerID=8YFLogxK
U2 - 10.1016/0006-291X(88)90486-X
DO - 10.1016/0006-291X(88)90486-X
M3 - Article
C2 - 2962584
AN - SCOPUS:0023868313
VL - 150
SP - 60
EP - 67
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 1
ER -