Augmented synthesis of β-human atrial natriuretic polypeptide in human failing hearts

Akira Sugawara, Kazuwa Nakao, Narito Morii, Takayuki Yamada, Hiroshi Itoh, Shozo Shiono, Yoshihiko Saito, Masashi Mukoyama, Hiroshi Arai, Kazunobu Nishimura, Kenji Obata, Hirofumi Yasue, Toshihiko Ban, Hiroo Imura

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Abstract

To elucidate the synthesis of atrial natriuretic polypeptide (ANP) in the failing heart, eighteen human right auricles obtained at cardiovascular surgery were studied. The concentration of α-human ANP-like immunoreactivity (α-hANP-LI) in human right auricles ranged from 13.8 to 593.5 μg/g, and the tissue α-hANP-LI concentration in severe congestive heart failure (CHF) (New York Heart Association (NYHA) functional class III or IV) was much higher than those in mild CHF of NYHA class I and class II. The α-hANP-LI in the human auricle consisted of 3 major components of ANP, γ-human ANP (γ-hANP), β-human ANP (β-hANP) and α-human ANP (α-hANP). The predominant component of α-hANP-LI was γ-hANP in the mild CHF, whereas β-hANP and/or α-hANP were prevailing in the severe CHF and, especially, β-hANP was markedly increased in human failing hearts.

Original languageEnglish
Pages (from-to)60-67
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume150
Issue number1
DOIs
Publication statusPublished - 1988 Jan 15
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Sugawara, A., Nakao, K., Morii, N., Yamada, T., Itoh, H., Shiono, S., Saito, Y., Mukoyama, M., Arai, H., Nishimura, K., Obata, K., Yasue, H., Ban, T., & Imura, H. (1988). Augmented synthesis of β-human atrial natriuretic polypeptide in human failing hearts. Biochemical and Biophysical Research Communications, 150(1), 60-67. https://doi.org/10.1016/0006-291X(88)90486-X