Augmented synthesis of β-human atrial natriuretic polypeptide in human failing hearts

Akira Sugawara, Kazuwa Nakao, Narito Morii, Takayuki Yamada, Hiroshi Itoh, Shozo Shiono, Yoshihiko Saito, Masashi Mukoyama, Hiroshi Arai, Kazunobu Nishimura, Kenji Obata, Hirofumi Yasue, Toshihiko Ban, Hiroo Imura

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

To elucidate the synthesis of atrial natriuretic polypeptide (ANP) in the failing heart, eighteen human right auricles obtained at cardiovascular surgery were studied. The concentration of α-human ANP-like immunoreactivity (α-hANP-LI) in human right auricles ranged from 13.8 to 593.5 μg/g, and the tissue α-hANP-LI concentration in severe congestive heart failure (CHF) (New York Heart Association (NYHA) functional class III or IV) was much higher than those in mild CHF of NYHA class I and class II. The α-hANP-LI in the human auricle consisted of 3 major components of ANP, γ-human ANP (γ-hANP), β-human ANP (β-hANP) and α-human ANP (α-hANP). The predominant component of α-hANP-LI was γ-hANP in the mild CHF, whereas β-hANP and/or α-hANP were prevailing in the severe CHF and, especially, β-hANP was markedly increased in human failing hearts.

Original languageEnglish
Pages (from-to)60-67
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume150
Issue number1
DOIs
Publication statusPublished - 1988 Jan 15
Externally publishedYes

Fingerprint

Peptides
Heart Failure
Cardiovascular surgery
Tissue

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Augmented synthesis of β-human atrial natriuretic polypeptide in human failing hearts. / Sugawara, Akira; Nakao, Kazuwa; Morii, Narito; Yamada, Takayuki; Itoh, Hiroshi; Shiono, Shozo; Saito, Yoshihiko; Mukoyama, Masashi; Arai, Hiroshi; Nishimura, Kazunobu; Obata, Kenji; Yasue, Hirofumi; Ban, Toshihiko; Imura, Hiroo.

In: Biochemical and Biophysical Research Communications, Vol. 150, No. 1, 15.01.1988, p. 60-67.

Research output: Contribution to journalArticle

Sugawara, A, Nakao, K, Morii, N, Yamada, T, Itoh, H, Shiono, S, Saito, Y, Mukoyama, M, Arai, H, Nishimura, K, Obata, K, Yasue, H, Ban, T & Imura, H 1988, 'Augmented synthesis of β-human atrial natriuretic polypeptide in human failing hearts', Biochemical and Biophysical Research Communications, vol. 150, no. 1, pp. 60-67. https://doi.org/10.1016/0006-291X(88)90486-X
Sugawara, Akira ; Nakao, Kazuwa ; Morii, Narito ; Yamada, Takayuki ; Itoh, Hiroshi ; Shiono, Shozo ; Saito, Yoshihiko ; Mukoyama, Masashi ; Arai, Hiroshi ; Nishimura, Kazunobu ; Obata, Kenji ; Yasue, Hirofumi ; Ban, Toshihiko ; Imura, Hiroo. / Augmented synthesis of β-human atrial natriuretic polypeptide in human failing hearts. In: Biochemical and Biophysical Research Communications. 1988 ; Vol. 150, No. 1. pp. 60-67.
@article{7078d1255a4c40e784b8d645f47cb77f,
title = "Augmented synthesis of β-human atrial natriuretic polypeptide in human failing hearts",
abstract = "To elucidate the synthesis of atrial natriuretic polypeptide (ANP) in the failing heart, eighteen human right auricles obtained at cardiovascular surgery were studied. The concentration of α-human ANP-like immunoreactivity (α-hANP-LI) in human right auricles ranged from 13.8 to 593.5 μg/g, and the tissue α-hANP-LI concentration in severe congestive heart failure (CHF) (New York Heart Association (NYHA) functional class III or IV) was much higher than those in mild CHF of NYHA class I and class II. The α-hANP-LI in the human auricle consisted of 3 major components of ANP, γ-human ANP (γ-hANP), β-human ANP (β-hANP) and α-human ANP (α-hANP). The predominant component of α-hANP-LI was γ-hANP in the mild CHF, whereas β-hANP and/or α-hANP were prevailing in the severe CHF and, especially, β-hANP was markedly increased in human failing hearts.",
author = "Akira Sugawara and Kazuwa Nakao and Narito Morii and Takayuki Yamada and Hiroshi Itoh and Shozo Shiono and Yoshihiko Saito and Masashi Mukoyama and Hiroshi Arai and Kazunobu Nishimura and Kenji Obata and Hirofumi Yasue and Toshihiko Ban and Hiroo Imura",
year = "1988",
month = "1",
day = "15",
doi = "10.1016/0006-291X(88)90486-X",
language = "English",
volume = "150",
pages = "60--67",
journal = "Biochemical and Biophysical Research Communications",
issn = "0006-291X",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - Augmented synthesis of β-human atrial natriuretic polypeptide in human failing hearts

AU - Sugawara, Akira

AU - Nakao, Kazuwa

AU - Morii, Narito

AU - Yamada, Takayuki

AU - Itoh, Hiroshi

AU - Shiono, Shozo

AU - Saito, Yoshihiko

AU - Mukoyama, Masashi

AU - Arai, Hiroshi

AU - Nishimura, Kazunobu

AU - Obata, Kenji

AU - Yasue, Hirofumi

AU - Ban, Toshihiko

AU - Imura, Hiroo

PY - 1988/1/15

Y1 - 1988/1/15

N2 - To elucidate the synthesis of atrial natriuretic polypeptide (ANP) in the failing heart, eighteen human right auricles obtained at cardiovascular surgery were studied. The concentration of α-human ANP-like immunoreactivity (α-hANP-LI) in human right auricles ranged from 13.8 to 593.5 μg/g, and the tissue α-hANP-LI concentration in severe congestive heart failure (CHF) (New York Heart Association (NYHA) functional class III or IV) was much higher than those in mild CHF of NYHA class I and class II. The α-hANP-LI in the human auricle consisted of 3 major components of ANP, γ-human ANP (γ-hANP), β-human ANP (β-hANP) and α-human ANP (α-hANP). The predominant component of α-hANP-LI was γ-hANP in the mild CHF, whereas β-hANP and/or α-hANP were prevailing in the severe CHF and, especially, β-hANP was markedly increased in human failing hearts.

AB - To elucidate the synthesis of atrial natriuretic polypeptide (ANP) in the failing heart, eighteen human right auricles obtained at cardiovascular surgery were studied. The concentration of α-human ANP-like immunoreactivity (α-hANP-LI) in human right auricles ranged from 13.8 to 593.5 μg/g, and the tissue α-hANP-LI concentration in severe congestive heart failure (CHF) (New York Heart Association (NYHA) functional class III or IV) was much higher than those in mild CHF of NYHA class I and class II. The α-hANP-LI in the human auricle consisted of 3 major components of ANP, γ-human ANP (γ-hANP), β-human ANP (β-hANP) and α-human ANP (α-hANP). The predominant component of α-hANP-LI was γ-hANP in the mild CHF, whereas β-hANP and/or α-hANP were prevailing in the severe CHF and, especially, β-hANP was markedly increased in human failing hearts.

UR - http://www.scopus.com/inward/record.url?scp=0023868313&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023868313&partnerID=8YFLogxK

U2 - 10.1016/0006-291X(88)90486-X

DO - 10.1016/0006-291X(88)90486-X

M3 - Article

C2 - 2962584

AN - SCOPUS:0023868313

VL - 150

SP - 60

EP - 67

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

SN - 0006-291X

IS - 1

ER -