Aurora-A - A guardian of poles

Tomotoshi Marumoto, Dongwei Zhang, Hideyuki Saya

Research output: Contribution to journalArticle

549 Citations (Scopus)

Abstract

The three human homologues of Aurora kinases (A, B and C) are essential for proper execution of various mitotic events and are important for maintaining genomic integrity. Aurora-A is mainly localized at spindle poles and the mitotic spindle during mitosis, where it regulates the functions of centrosomes, spindles and kinetochores required for proper mitotic progression. Recent studies have revealed that Aurora-A is frequently overexpressed in various cancer cells, indicating its involvement in tumorigenesis. What are the normal physiological roles of Aurora-A, how are these regulated and how might the enzyme function during tumorigenesis?

Original languageEnglish
Pages (from-to)42-50
Number of pages9
JournalNature Reviews Cancer
Volume5
Issue number1
DOIs
Publication statusPublished - 2005 Jan
Externally publishedYes

Fingerprint

Carcinogenesis
Aurora Kinase B
Aurora Kinase A
Spindle Poles
Kinetochores
Centrosome
Spindle Apparatus
Mitosis
Enzymes
Neoplasms
human AURKC protein

ASJC Scopus subject areas

  • Cancer Research

Cite this

Aurora-A - A guardian of poles. / Marumoto, Tomotoshi; Zhang, Dongwei; Saya, Hideyuki.

In: Nature Reviews Cancer, Vol. 5, No. 1, 01.2005, p. 42-50.

Research output: Contribution to journalArticle

Marumoto, Tomotoshi ; Zhang, Dongwei ; Saya, Hideyuki. / Aurora-A - A guardian of poles. In: Nature Reviews Cancer. 2005 ; Vol. 5, No. 1. pp. 42-50.
@article{fc815812a082468d8c1053e7e50bb4a7,
title = "Aurora-A - A guardian of poles",
abstract = "The three human homologues of Aurora kinases (A, B and C) are essential for proper execution of various mitotic events and are important for maintaining genomic integrity. Aurora-A is mainly localized at spindle poles and the mitotic spindle during mitosis, where it regulates the functions of centrosomes, spindles and kinetochores required for proper mitotic progression. Recent studies have revealed that Aurora-A is frequently overexpressed in various cancer cells, indicating its involvement in tumorigenesis. What are the normal physiological roles of Aurora-A, how are these regulated and how might the enzyme function during tumorigenesis?",
author = "Tomotoshi Marumoto and Dongwei Zhang and Hideyuki Saya",
year = "2005",
month = "1",
doi = "10.1038/nrc1526",
language = "English",
volume = "5",
pages = "42--50",
journal = "Nature Reviews Cancer",
issn = "1474-175X",
publisher = "Nature Publishing Group",
number = "1",

}

TY - JOUR

T1 - Aurora-A - A guardian of poles

AU - Marumoto, Tomotoshi

AU - Zhang, Dongwei

AU - Saya, Hideyuki

PY - 2005/1

Y1 - 2005/1

N2 - The three human homologues of Aurora kinases (A, B and C) are essential for proper execution of various mitotic events and are important for maintaining genomic integrity. Aurora-A is mainly localized at spindle poles and the mitotic spindle during mitosis, where it regulates the functions of centrosomes, spindles and kinetochores required for proper mitotic progression. Recent studies have revealed that Aurora-A is frequently overexpressed in various cancer cells, indicating its involvement in tumorigenesis. What are the normal physiological roles of Aurora-A, how are these regulated and how might the enzyme function during tumorigenesis?

AB - The three human homologues of Aurora kinases (A, B and C) are essential for proper execution of various mitotic events and are important for maintaining genomic integrity. Aurora-A is mainly localized at spindle poles and the mitotic spindle during mitosis, where it regulates the functions of centrosomes, spindles and kinetochores required for proper mitotic progression. Recent studies have revealed that Aurora-A is frequently overexpressed in various cancer cells, indicating its involvement in tumorigenesis. What are the normal physiological roles of Aurora-A, how are these regulated and how might the enzyme function during tumorigenesis?

UR - http://www.scopus.com/inward/record.url?scp=11144225241&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=11144225241&partnerID=8YFLogxK

U2 - 10.1038/nrc1526

DO - 10.1038/nrc1526

M3 - Article

C2 - 15630414

AN - SCOPUS:11144225241

VL - 5

SP - 42

EP - 50

JO - Nature Reviews Cancer

JF - Nature Reviews Cancer

SN - 1474-175X

IS - 1

ER -