Abstract
The three human homologues of Aurora kinases (A, B and C) are essential for proper execution of various mitotic events and are important for maintaining genomic integrity. Aurora-A is mainly localized at spindle poles and the mitotic spindle during mitosis, where it regulates the functions of centrosomes, spindles and kinetochores required for proper mitotic progression. Recent studies have revealed that Aurora-A is frequently overexpressed in various cancer cells, indicating its involvement in tumorigenesis. What are the normal physiological roles of Aurora-A, how are these regulated and how might the enzyme function during tumorigenesis?
| Original language | English |
|---|---|
| Pages (from-to) | 42-50 |
| Number of pages | 9 |
| Journal | Nature Reviews Cancer |
| Volume | 5 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2005 Jan 1 |
ASJC Scopus subject areas
- Oncology
- Cancer Research
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Cite this
Marumoto, T., Zhang, D., & Saya, H. (2005). Aurora-A - A guardian of poles. Nature Reviews Cancer, 5(1), 42-50. https://doi.org/10.1038/nrc1526