Aurora-A - A guardian of poles

Tomotoshi Marumoto; Dongwei Zhang; Hideyuki Saya

doi:10.1038/nrc1526

Aurora-A - A guardian of poles

Tomotoshi Marumoto, Dongwei Zhang, Hideyuki Saya

Division of Gene Regulation

Research output: Contribution to journal › Review article

551 Citations (Scopus)

Abstract

The three human homologues of Aurora kinases (A, B and C) are essential for proper execution of various mitotic events and are important for maintaining genomic integrity. Aurora-A is mainly localized at spindle poles and the mitotic spindle during mitosis, where it regulates the functions of centrosomes, spindles and kinetochores required for proper mitotic progression. Recent studies have revealed that Aurora-A is frequently overexpressed in various cancer cells, indicating its involvement in tumorigenesis. What are the normal physiological roles of Aurora-A, how are these regulated and how might the enzyme function during tumorigenesis?

Original language	English
Pages (from-to)	42-50
Number of pages	9
Journal	Nature Reviews Cancer
Volume	5
Issue number	1
DOIs	https://doi.org/10.1038/nrc1526
Publication status	Published - 2005 Jan 1

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ASJC Scopus subject areas

Oncology
Cancer Research

Cite this

Marumoto, T., Zhang, D., & Saya, H. (2005). Aurora-A - A guardian of poles. Nature Reviews Cancer, 5(1), 42-50. https://doi.org/10.1038/nrc1526

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10.1038/nrc1526