Abstract
The three human homologues of Aurora kinases (A, B and C) are essential for proper execution of various mitotic events and are important for maintaining genomic integrity. Aurora-A is mainly localized at spindle poles and the mitotic spindle during mitosis, where it regulates the functions of centrosomes, spindles and kinetochores required for proper mitotic progression. Recent studies have revealed that Aurora-A is frequently overexpressed in various cancer cells, indicating its involvement in tumorigenesis. What are the normal physiological roles of Aurora-A, how are these regulated and how might the enzyme function during tumorigenesis?
| Original language | English |
|---|---|
| Pages (from-to) | 42-50 |
| Number of pages | 9 |
| Journal | Nature Reviews Cancer |
| Volume | 5 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2005 Jan |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cancer Research
Cite this
Aurora-A - A guardian of poles. / Marumoto, Tomotoshi; Zhang, Dongwei; Saya, Hideyuki.
In: Nature Reviews Cancer, Vol. 5, No. 1, 01.2005, p. 42-50.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Aurora-A - A guardian of poles
AU - Marumoto, Tomotoshi
AU - Zhang, Dongwei
AU - Saya, Hideyuki
PY - 2005/1
Y1 - 2005/1
N2 - The three human homologues of Aurora kinases (A, B and C) are essential for proper execution of various mitotic events and are important for maintaining genomic integrity. Aurora-A is mainly localized at spindle poles and the mitotic spindle during mitosis, where it regulates the functions of centrosomes, spindles and kinetochores required for proper mitotic progression. Recent studies have revealed that Aurora-A is frequently overexpressed in various cancer cells, indicating its involvement in tumorigenesis. What are the normal physiological roles of Aurora-A, how are these regulated and how might the enzyme function during tumorigenesis?
AB - The three human homologues of Aurora kinases (A, B and C) are essential for proper execution of various mitotic events and are important for maintaining genomic integrity. Aurora-A is mainly localized at spindle poles and the mitotic spindle during mitosis, where it regulates the functions of centrosomes, spindles and kinetochores required for proper mitotic progression. Recent studies have revealed that Aurora-A is frequently overexpressed in various cancer cells, indicating its involvement in tumorigenesis. What are the normal physiological roles of Aurora-A, how are these regulated and how might the enzyme function during tumorigenesis?
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U2 - 10.1038/nrc1526
DO - 10.1038/nrc1526
M3 - Article
VL - 5
SP - 42
EP - 50
JO - Nature Reviews Cancer
JF - Nature Reviews Cancer
SN - 1474-175X
IS - 1
ER -