Aurora-A - A guardian of poles

Tomotoshi Marumoto, Dongwei Zhang, Hideyuki Saya

Research output: Contribution to journalReview article

553 Citations (Scopus)

Abstract

The three human homologues of Aurora kinases (A, B and C) are essential for proper execution of various mitotic events and are important for maintaining genomic integrity. Aurora-A is mainly localized at spindle poles and the mitotic spindle during mitosis, where it regulates the functions of centrosomes, spindles and kinetochores required for proper mitotic progression. Recent studies have revealed that Aurora-A is frequently overexpressed in various cancer cells, indicating its involvement in tumorigenesis. What are the normal physiological roles of Aurora-A, how are these regulated and how might the enzyme function during tumorigenesis?

Original languageEnglish
Pages (from-to)42-50
Number of pages9
JournalNature Reviews Cancer
Volume5
Issue number1
DOIs
Publication statusPublished - 2005 Jan 1

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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