TY - JOUR
T1 - Aurora-A - A guardian of poles
AU - Marumoto, Tomotoshi
AU - Zhang, Dongwei
AU - Saya, Hideyuki
N1 - Funding Information:
We thank T. Hirota, T. Sasayama, S. Iida, S. Kuninaka, T. Hara, N. Kunitoku, N. Araki and T. Mimori for helpful discussion. This work was supported by a grant for Cancer Research from the Ministry of Education, Science and Culture of Japan (H.S.) and ‘Research for the Future’ programme of the Japan Society for the Promotion of Science (H.S.).
PY - 2005/1
Y1 - 2005/1
N2 - The three human homologues of Aurora kinases (A, B and C) are essential for proper execution of various mitotic events and are important for maintaining genomic integrity. Aurora-A is mainly localized at spindle poles and the mitotic spindle during mitosis, where it regulates the functions of centrosomes, spindles and kinetochores required for proper mitotic progression. Recent studies have revealed that Aurora-A is frequently overexpressed in various cancer cells, indicating its involvement in tumorigenesis. What are the normal physiological roles of Aurora-A, how are these regulated and how might the enzyme function during tumorigenesis?
AB - The three human homologues of Aurora kinases (A, B and C) are essential for proper execution of various mitotic events and are important for maintaining genomic integrity. Aurora-A is mainly localized at spindle poles and the mitotic spindle during mitosis, where it regulates the functions of centrosomes, spindles and kinetochores required for proper mitotic progression. Recent studies have revealed that Aurora-A is frequently overexpressed in various cancer cells, indicating its involvement in tumorigenesis. What are the normal physiological roles of Aurora-A, how are these regulated and how might the enzyme function during tumorigenesis?
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U2 - 10.1038/nrc1526
DO - 10.1038/nrc1526
M3 - Review article
C2 - 15630414
AN - SCOPUS:11144225241
VL - 5
SP - 42
EP - 50
JO - Nature Reviews Cancer
JF - Nature Reviews Cancer
SN - 1474-175X
IS - 1
ER -
