Autobiographical memory loss following herpes encephalitis

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We report a patient with prominent autobiographical memory (ABM) impairment, and discussed possible mechanisms of her deficits. The patient was a 36-year-old woman who suffered from herpes simplex encephalitis in November 1994. Four months after the onset, the neuropsychological examination disclosed that her intelligence, attention, language and frontal lobe functions were normal. Moderate anterograde amnesia was evident for visual materials, and she showed difficulties in retrieving visual images. Deficits in verbal learning were minimal. In contrast, her retrograde amnesia (RA) was severe. Further analyses clarified that memory for public events and personal semantic memory were relatively well preserved whereas ABM was severely impaired with no evidence of temporal gradient. Her performance on the ABM questionnaire was even worse than that of alcoholic Korsakoff patients. Interestingly, however, deficits in memory for public events also emerged when questions were presented with pictures instead of ordinary verbal questionnaires. The results suggest that her principle deficits consisted n utilizing visual information of the past events. Her access to and manipulation of the past visual representation/images were impaired. Consequently, her deficits were almost exclusive to ABM because visual information is most crucial for ABM. This material specific ABM impairment demonstrated in the present patient could be differentiated from nonspecific retrograde amnesia observed in typical focal RA patients. MRI, SPECT and PET demonstrated that the present patient had lesions basically in the right hemisphere, specifically in the medial temporal area including the hippocampus.

Original languageEnglish
Pages (from-to)759-764
Number of pages6
JournalBrain and Nerve
Volume49
Issue number8
Publication statusPublished - 1997
Externally publishedYes

Fingerprint

Herpes Simplex Encephalitis
Episodic Memory
Memory Disorders
Retrograde Amnesia
Anterograde Amnesia
Verbal Learning
Frontal Lobe
Single-Photon Emission-Computed Tomography
Intelligence
Semantics
Hippocampus
Language

Keywords

  • Autobiographical memory
  • Herpes encephalitis
  • Retrograde amnesia
  • Visual image

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Autobiographical memory loss following herpes encephalitis. / Mimura, Masaru.

In: Brain and Nerve, Vol. 49, No. 8, 1997, p. 759-764.

Research output: Contribution to journalArticle

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